ID   F187A_HUMAN             Reviewed;         413 AA.
AC   A6NFU0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Ig-like V-type domain-containing protein FAM187A;
DE   Flags: Precursor;
GN   Name=FAM187A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM187 family. {ECO:0000305}.
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DR   EMBL; AC015936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS86601.1; -.
DR   AlphaFoldDB; A6NFU0; -.
DR   GlyGen; A6NFU0; 1 site.
DR   BioMuta; FAM187A; -.
DR   MassIVE; A6NFU0; -.
DR   PaxDb; A6NFU0; -.
DR   PeptideAtlas; A6NFU0; -.
DR   PRIDE; A6NFU0; -.
DR   ProteomicsDB; 1077; -.
DR   Antibodypedia; 8284; 4 antibodies from 4 providers.
DR   Ensembl; ENST00000331733.4; ENSP00000329499.4; ENSG00000214447.5.
DR   UCSC; uc002ihp.2; human.
DR   GeneCards; FAM187A; -.
DR   HGNC; HGNC:35153; FAM187A.
DR   HPA; ENSG00000214447; Tissue enhanced (fallopian tube, testis).
DR   neXtProt; NX_A6NFU0; -.
DR   VEuPathDB; HostDB:ENSG00000214447; -.
DR   GeneTree; ENSGT00530000063991; -.
DR   HOGENOM; CLU_054403_0_0_1; -.
DR   InParanoid; A6NFU0; -.
DR   PhylomeDB; A6NFU0; -.
DR   TreeFam; TF332178; -.
DR   PathwayCommons; A6NFU0; -.
DR   SignaLink; A6NFU0; -.
DR   Pharos; A6NFU0; Tdark.
DR   PRO; PR:A6NFU0; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; A6NFU0; protein.
DR   Bgee; ENSG00000214447; Expressed in left testis and 93 other tissues.
DR   Genevisible; A6NFU0; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR039311; FAM187A/B.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR32178; PTHR32178; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..413
FT                   /note="Ig-like V-type domain-containing protein FAM187A"
FT                   /id="PRO_0000340654"
FT   TOPO_DOM        18..376
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        398..413
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          267..361
FT                   /note="Ig-like V-type"
FT   CARBOHYD        317
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        289..345
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   413 AA;  47349 MW;  580178965D3F9631 CRC64;
     MHLALTTVLL WAWGLQAFEI VEKENIFQRT PCPAFLMFEN AAYLADMSFE LPCHCKPEEV
     PAVVWFYQKH LGSSHTKVLT DFDGRVLTEA AQVRVGSDML TRFSIRMFSL LVFRAQSEDS
     GLYFCGTRKG DYFYAYDVDI QNSEGMVATF QDKGQEPFAD EYYGHLHVFT TFWEWTPCDR
     CGVRGEQWRI GLCYLQSPDL SPRYLKAVPD VVSCGSRAVP RKLRTKARDH TPEVLVRSCL
     VPCEKTKTIR EGVLAIINYV SKVGSRPWVP QVPIQFHQQR LGHGLIISCP GARPEHAVAW
     DKDRQHLYRT QYLKGVNRSM RVFIDHGNQL HIRFTQLDDR GIYYCWRQGV LVAGFRLGVT
     SHGHYPASFS DPETRSAVEL TLIGYLLITA VFVTIHFCRC CCYLFHCCPS FSP