F187A_MOUSE
ID F187A_MOUSE Reviewed; 417 AA.
AC Q9D3R5; Q9D3Y8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Ig-like V-type domain-containing protein FAM187A;
DE Flags: Precursor;
GN Name=Fam187a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM187 family. {ECO:0000305}.
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DR EMBL; AK016939; BAB30509.1; -; mRNA.
DR EMBL; AK017119; BAB30607.1; -; mRNA.
DR EMBL; BC116769; AAI16770.1; -; mRNA.
DR EMBL; BC116771; AAI16772.1; -; mRNA.
DR CCDS; CCDS48949.1; -.
DR RefSeq; NP_080042.1; NM_025766.2.
DR AlphaFoldDB; Q9D3R5; -.
DR STRING; 10090.ENSMUSP00000097938; -.
DR GlyGen; Q9D3R5; 2 sites.
DR PaxDb; Q9D3R5; -.
DR PRIDE; Q9D3R5; -.
DR ProteomicsDB; 275986; -.
DR Antibodypedia; 8284; 4 antibodies from 4 providers.
DR Ensembl; ENSMUST00000100369; ENSMUSP00000097938; ENSMUSG00000075510.
DR GeneID; 66784; -.
DR KEGG; mmu:66784; -.
DR UCSC; uc007lsu.2; mouse.
DR CTD; 100528020; -.
DR MGI; MGI:1914034; Fam187a.
DR VEuPathDB; HostDB:ENSMUSG00000075510; -.
DR eggNOG; ENOG502QRCU; Eukaryota.
DR GeneTree; ENSGT00530000063991; -.
DR HOGENOM; CLU_054403_0_0_1; -.
DR InParanoid; Q9D3R5; -.
DR OMA; IFTTFWE; -.
DR OrthoDB; 1171180at2759; -.
DR PhylomeDB; Q9D3R5; -.
DR TreeFam; TF332178; -.
DR BioGRID-ORCS; 66784; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9D3R5; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9D3R5; protein.
DR Bgee; ENSMUSG00000075510; Expressed in spermatid and 15 other tissues.
DR Genevisible; Q9D3R5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR039311; FAM187A/B.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR32178; PTHR32178; 1.
DR Pfam; PF07686; V-set; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..417
FT /note="Ig-like V-type domain-containing protein FAM187A"
FT /id="PRO_0000340655"
FT TOPO_DOM 19..377
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..417
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 268..362
FT /note="Ig-like V-type"
FT CARBOHYD 248
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 318
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 290..346
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 121
FT /note="T -> I (in Ref. 1; BAB30509)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 417 AA; 47878 MW; 65F0A90EF878E261 CRC64;
MSLAHTTVLL WAWGSLQAFE IVEKESVFQR TPCPAFLVFD NAAYLADMSF ELPCHCKPED
VSAVVWYYQK HLGSKRTTVL TDFDGRLLTE AAHVRVGSSM LVRFSIRMFS LLVFRAQPED
TGLYFCGTRE GDYFYAYDVD IQSNKEIVAS FKDMAQEPLP DEYYGALHVF TTFWEWTPCD
RCGVRGEQWR FGLCYLQYPD LSPRYIKTRS AVVSCGSGAV PWKLHLQTKY HTPELQFQSC
LVSCQKRNKT RKGVLAIYSY VSKLGSRPWV PQVPIQFHQQ RLGHGLIISC PGARPEHAVA
WDKDNQPLYR AQYLKGVNRS MRVFIDHGNH LHIRFTQLSD RGIYYCWLQG LKIAGFRLGV
ITRGRYPASL SDPETRTAIE LTLMGYLLIT IFFITIHLCR CCCQSRCCPN FSAQTLL
