ID   F187A_RAT               Reviewed;         418 AA.
AC   Q6AXV7;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Ig-like V-type domain-containing protein FAM187A;
DE   Flags: Precursor;
GN   Name=Fam187a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM187 family. {ECO:0000305}.
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DR   EMBL; BC079299; AAH79299.1; -; mRNA.
DR   RefSeq; NP_001013883.1; NM_001013861.1.
DR   AlphaFoldDB; Q6AXV7; -.
DR   STRING; 10116.ENSRNOP00000003892; -.
DR   GlyGen; Q6AXV7; 1 site.
DR   PaxDb; Q6AXV7; -.
DR   PRIDE; Q6AXV7; -.
DR   Ensembl; ENSRNOT00000003892; ENSRNOP00000003892; ENSRNOG00000002918.
DR   GeneID; 287741; -.
DR   KEGG; rno:287741; -.
DR   UCSC; RGD:1307851; rat.
DR   CTD; 100528020; -.
DR   RGD; 1307851; RGD1307851.
DR   eggNOG; ENOG502QRCU; Eukaryota.
DR   GeneTree; ENSGT00530000063991; -.
DR   HOGENOM; CLU_054403_0_0_1; -.
DR   InParanoid; Q6AXV7; -.
DR   OMA; IFTTFWE; -.
DR   OrthoDB; 1171180at2759; -.
DR   PhylomeDB; Q6AXV7; -.
DR   TreeFam; TF332178; -.
DR   PRO; PR:Q6AXV7; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000002918; Expressed in testis.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR039311; FAM187A/B.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR32178; PTHR32178; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..418
FT                   /note="Ig-like V-type domain-containing protein FAM187A"
FT                   /id="PRO_0000340656"
FT   TOPO_DOM        19..376
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        398..418
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          267..361
FT                   /note="Ig-like V-type"
FT   CARBOHYD        317
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        289..345
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   418 AA;  47804 MW;  BF9DC8C5EB1A3766 CRC64;
     MRLAPTTVLL WAWGSLQAFE IVEKENIFQR TPCPAFLVFD NTAYLADMSF ELPCHCKPED
     VSAVVWYYQK YLGSSHTTVL TDFDGRLLTE AAHVRVGSSM LARFSIRMFS LLVFRAQPED
     SGLYFCGTRN GDYFYAYDVD IQSHKGMVAS FRDKGQEPLP DEYYGSLHVF TTFWEWTPCD
     RCGVRGEQWR FGLCYLQNPN LSPRYIKTLP DVVSCGSRAV PWKLHLKTKY HTPELLIQSC
     LVSCKKNKMG EGILAIYNYV SKLGGRPWVP QVPIQFHQQR LGHGLIISCP GARPEHAVAW
     DKDSQPLYRT QYLKGVNRSM RVFIDHGNHL HIRFTQLSDR GIYYCWRQGL KIAGFRLGVT
     SRGRYPASLS DPETRTAVEL TLIGYLLIAV VFVTIHLCRC CCQSRCCPNF SAQTLLQL