F187B_HUMAN
ID F187B_HUMAN Reviewed; 369 AA.
AC Q17R55; Q8N7G6;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein FAM187B;
DE AltName: Full=Transmembrane protein 162;
DE Flags: Precursor;
GN Name=FAM187B; Synonyms=TMEM162;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-160.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-3.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM187 family. {ECO:0000305}.
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DR EMBL; AK098526; BAC05322.1; -; mRNA.
DR EMBL; BC117457; AAI17458.1; -; mRNA.
DR EMBL; BC117459; AAI17460.1; -; mRNA.
DR CCDS; CCDS12448.1; -.
DR RefSeq; NP_689694.1; NM_152481.1.
DR AlphaFoldDB; Q17R55; -.
DR BioGRID; 127118; 59.
DR IntAct; Q17R55; 10.
DR STRING; 9606.ENSP00000323355; -.
DR GlyGen; Q17R55; 3 sites.
DR iPTMnet; Q17R55; -.
DR PhosphoSitePlus; Q17R55; -.
DR BioMuta; FAM187B; -.
DR DMDM; 145566967; -.
DR MassIVE; Q17R55; -.
DR PaxDb; Q17R55; -.
DR PeptideAtlas; Q17R55; -.
DR PRIDE; Q17R55; -.
DR ProteomicsDB; 61135; -.
DR Antibodypedia; 3047; 43 antibodies from 11 providers.
DR DNASU; 148109; -.
DR Ensembl; ENST00000324675.4; ENSP00000323355.3; ENSG00000177558.4.
DR GeneID; 148109; -.
DR KEGG; hsa:148109; -.
DR MANE-Select; ENST00000324675.4; ENSP00000323355.3; NM_152481.2; NP_689694.1.
DR UCSC; uc002nyk.2; human.
DR CTD; 148109; -.
DR GeneCards; FAM187B; -.
DR HGNC; HGNC:26366; FAM187B.
DR HPA; ENSG00000177558; Tissue enriched (testis).
DR neXtProt; NX_Q17R55; -.
DR OpenTargets; ENSG00000177558; -.
DR PharmGKB; PA164719910; -.
DR VEuPathDB; HostDB:ENSG00000177558; -.
DR eggNOG; ENOG502S0YJ; Eukaryota.
DR GeneTree; ENSGT00530000063991; -.
DR HOGENOM; CLU_054403_0_0_1; -.
DR InParanoid; Q17R55; -.
DR OMA; EACHVQC; -.
DR OrthoDB; 1290951at2759; -.
DR PhylomeDB; Q17R55; -.
DR TreeFam; TF332178; -.
DR PathwayCommons; Q17R55; -.
DR SignaLink; Q17R55; -.
DR BioGRID-ORCS; 148109; 15 hits in 1061 CRISPR screens.
DR GenomeRNAi; 148109; -.
DR Pharos; Q17R55; Tdark.
DR PRO; PR:Q17R55; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q17R55; protein.
DR Bgee; ENSG00000177558; Expressed in right testis and 51 other tissues.
DR Genevisible; Q17R55; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR039311; FAM187A/B.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR32178; PTHR32178; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..369
FT /note="Protein FAM187B"
FT /id="PRO_0000284626"
FT TOPO_DOM 18..335
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 3
FT /note="P -> S (in dbSNP:rs34873156)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031790"
FT VARIANT 160
FT /note="C -> R (in dbSNP:rs565791)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_031791"
FT VARIANT 216
FT /note="V -> I (in dbSNP:rs564117)"
FT /id="VAR_031792"
SQ SEQUENCE 369 AA; 42387 MW; 1EAD9CAC56D13E70 CRC64;
MPPMLWLLLH FAAPALGFYF SISCPSGKQC QQALLSGNDI LLYCNSSGAH WYYLFTQGKK
GRLTSLTNIS NMEIMPEGSL LIKDPLPSQT GLYHCWNKNG RQVVQYEIDF QDVTTLHITH
KDLGQRPLQN ETLHLGSKQL IFTWWEPWQD CNRCEEPGEC KRLGYRYIEE PLEEAMPCWL
YLGEVLVWSS RLRPELQVEA CHVQCTNNTQ LRVDYVIFDN FRLDEKTEFV WLDCPLGSMY
RPVNWRANDT PLTWESQLSG QDFTTFLDPS TGGRQLQVFQ PAVYKCFVQQ ELVAQFKPAA
SLETLEAQWR ENDAQWREAR KALRGRADSV LKGLKLVLLV VTVLALLGAL LKCIHPSPGR
RSTQVLVVK
