F187B_MOUSE
ID F187B_MOUSE Reviewed; 358 AA.
AC Q0VAY3; Q3UFH7;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein FAM187B;
DE AltName: Full=Transmembrane protein 162;
DE Flags: Precursor;
GN Name=Fam187b; Synonyms=Tmem162;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Pancreas, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0VAY3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0VAY3-2; Sequence=VSP_024580;
CC -!- SIMILARITY: Belongs to the FAM187 family. {ECO:0000305}.
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DR EMBL; AK148492; BAE28584.1; -; mRNA.
DR EMBL; BC120864; AAI20865.1; -; mRNA.
DR EMBL; BC125560; AAI25561.1; -; mRNA.
DR CCDS; CCDS21120.1; -. [Q0VAY3-1]
DR RefSeq; NP_780449.2; NM_175240.4. [Q0VAY3-1]
DR AlphaFoldDB; Q0VAY3; -.
DR STRING; 10090.ENSMUSP00000057020; -.
DR GlyGen; Q0VAY3; 1 site.
DR iPTMnet; Q0VAY3; -.
DR PhosphoSitePlus; Q0VAY3; -.
DR PaxDb; Q0VAY3; -.
DR PRIDE; Q0VAY3; -.
DR ProteomicsDB; 275987; -. [Q0VAY3-1]
DR ProteomicsDB; 275988; -. [Q0VAY3-2]
DR Antibodypedia; 3047; 43 antibodies from 11 providers.
DR DNASU; 76415; -.
DR Ensembl; ENSMUST00000058093; ENSMUSP00000057020; ENSMUSG00000046826. [Q0VAY3-1]
DR Ensembl; ENSMUST00000129773; ENSMUSP00000144533; ENSMUSG00000046826. [Q0VAY3-2]
DR GeneID; 76415; -.
DR KEGG; mmu:76415; -.
DR UCSC; uc009ghn.2; mouse. [Q0VAY3-1]
DR CTD; 148109; -.
DR MGI; MGI:1923665; Fam187b.
DR VEuPathDB; HostDB:ENSMUSG00000046826; -.
DR eggNOG; ENOG502S0YJ; Eukaryota.
DR GeneTree; ENSGT00530000063991; -.
DR InParanoid; Q0VAY3; -.
DR OMA; EACHVQC; -.
DR OrthoDB; 1290951at2759; -.
DR PhylomeDB; Q0VAY3; -.
DR TreeFam; TF332178; -.
DR BioGRID-ORCS; 76415; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q0VAY3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q0VAY3; protein.
DR Bgee; ENSMUSG00000046826; Expressed in spermatid and 46 other tissues.
DR ExpressionAtlas; Q0VAY3; baseline and differential.
DR Genevisible; Q0VAY3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039311; FAM187A/B.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR PANTHER; PTHR32178; PTHR32178; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..358
FT /note="Protein FAM187B"
FT /id="PRO_0000284628"
FT TOPO_DOM 18..322
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..263
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024580"
SQ SEQUENCE 358 AA; 40957 MW; 954853737D23C266 CRC64;
MLATLWLVGL SLPMLWAQRL ISCPYKNVCQ YALLSGSDVI LQCNYPKALW YFSSSLEDKL
SLVNSKPDGR VLPGSDLQLS DPKPSQTGLY RCLDNHKARL VEYEIDFQNI ALLHITHKDL
GQEPMGNESM NLGGKVLVFT RWDPWQDCNR CQKPGERKRL GYCYVEEPQE KPMPCWLYLR
EEKVTNSRLR PELQLQACQV PCDTATETNQ PYFVFDTYLL DKPNSNARLK CPLASIYRPV
HWEADNSPLT WQDQLSGQTV STIMDLHSGG QHLKVFQPAT YRCFVEQELI AQFNPTERQS
KAQNPWQPRI QPDKADSVLR RLKLMVLSIS VLAVGGLLCK VVFRPVCGKK RSQVLLVK
