F1891_MOUSE
ID F1891_MOUSE Reviewed; 515 AA.
AC Q6A044; Q8BHP9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 3.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Protein FAM189A1;
GN Name=Fam189a1; Synonyms=Kiaa0574;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6A044-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6A044-2; Sequence=VSP_032011;
CC -!- SIMILARITY: Belongs to the FAM189 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32252.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK172974; BAD32252.1; ALT_INIT; mRNA.
DR EMBL; CJ059135; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK017751; BAC25529.1; -; mRNA.
DR CCDS; CCDS21336.2; -. [Q6A044-1]
DR RefSeq; NP_898910.2; NM_183087.4. [Q6A044-1]
DR AlphaFoldDB; Q6A044; -.
DR STRING; 10090.ENSMUSP00000113680; -.
DR PhosphoSitePlus; Q6A044; -.
DR PaxDb; Q6A044; -.
DR PRIDE; Q6A044; -.
DR ProteomicsDB; 267688; -. [Q6A044-1]
DR ProteomicsDB; 267689; -. [Q6A044-2]
DR Antibodypedia; 2289; 29 antibodies from 10 providers.
DR Ensembl; ENSMUST00000119118; ENSMUSP00000113680; ENSMUSG00000030518. [Q6A044-1]
DR GeneID; 70638; -.
DR KEGG; mmu:70638; -.
DR UCSC; uc009hgl.2; mouse. [Q6A044-1]
DR CTD; 23359; -.
DR MGI; MGI:1917888; Fam189a1.
DR VEuPathDB; HostDB:ENSMUSG00000030518; -.
DR eggNOG; ENOG502QUMS; Eukaryota.
DR GeneTree; ENSGT00530000063335; -.
DR HOGENOM; CLU_025607_1_1_1; -.
DR InParanoid; Q6A044; -.
DR OMA; HVVGTIR; -.
DR OrthoDB; 608892at2759; -.
DR PhylomeDB; Q6A044; -.
DR TreeFam; TF332736; -.
DR BioGRID-ORCS; 70638; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Fam189a1; mouse.
DR PRO; PR:Q6A044; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q6A044; protein.
DR Bgee; ENSMUSG00000030518; Expressed in subiculum and 124 other tissues.
DR ExpressionAtlas; Q6A044; baseline and differential.
DR Genevisible; Q6A044; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR030431; FAM189.
DR PANTHER; PTHR17615; PTHR17615; 1.
DR Pfam; PF04103; CD20; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..515
FT /note="Protein FAM189A1"
FT /id="PRO_0000314456"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 312..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..376
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032011"
SQ SEQUENCE 515 AA; 54479 MW; F06F8580FD960607 CRC64;
MPPAGGPRTP RPHALPRSLS RLRECPGRSR IVLALGATQM ALGCLIVAVS FAALALTTSA
RVRHSCPFWA GFSVLLSGLI GVVSWKRPLS LVITFFMLLS AVCVMLNLAG SILSCQNAQL
VSSLEGCQLI KFDSVEVCVC CELQHHSSGC SNLGETLKLN PLQENCNAVR LTLKDLLFSV
CALNVLSTIV CALATAMCCM QMVSADVLQM FFPHRSHSAN AACVTPHGTI LHQTLDFDEF
IAPLPPPPYY PPEYTCTPTA EAHRGLHLDF ASSPFSTLYD VAINSPGILY PAELPPPYEA
VVGQTPASQV ASVDHQVVDS SSGDPNTAAD FSTPVPASST SLPTSEGATS LGPSHPSPDG
TLDTPTPLIP TPVPHHMSPE AASLSAQAQP SPGRVARSVS DPTSCTSSEA VSTSQPAMAA
CQHQHSSTGD PDTWKTGQGT KPETLQTVSK ERPHSLVESK AYADTRVLVA KFLEHAHCSL
PTEVRHVVGT IRSMATSEEP RVEEAIFGAG VLDQL
