ID   F189B_MOUSE             Reviewed;         669 AA.
AC   Q5HZJ5;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Protein FAM189B;
GN   Name=Fam189b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: May interact with WWOX. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM189 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC088990; AAH88990.1; -; mRNA.
DR   CCDS; CCDS17492.1; -.
DR   RefSeq; NP_001014995.1; NM_001014995.1.
DR   AlphaFoldDB; Q5HZJ5; -.
DR   IntAct; Q5HZJ5; 1.
DR   STRING; 10090.ENSMUSP00000039261; -.
DR   GlyGen; Q5HZJ5; 1 site.
DR   iPTMnet; Q5HZJ5; -.
DR   PhosphoSitePlus; Q5HZJ5; -.
DR   jPOST; Q5HZJ5; -.
DR   PaxDb; Q5HZJ5; -.
DR   PRIDE; Q5HZJ5; -.
DR   ProteomicsDB; 275990; -.
DR   Antibodypedia; 1675; 81 antibodies from 15 providers.
DR   DNASU; 68521; -.
DR   Ensembl; ENSMUST00000041913; ENSMUSP00000039261; ENSMUSG00000032657.
DR   GeneID; 68521; -.
DR   KEGG; mmu:68521; -.
DR   UCSC; uc008pxy.1; mouse.
DR   CTD; 10712; -.
DR   MGI; MGI:1915771; Fam189b.
DR   VEuPathDB; HostDB:ENSMUSG00000032657; -.
DR   eggNOG; ENOG502RB7D; Eukaryota.
DR   GeneTree; ENSGT00530000063335; -.
DR   InParanoid; Q5HZJ5; -.
DR   OMA; TARSCHR; -.
DR   OrthoDB; 608892at2759; -.
DR   PhylomeDB; Q5HZJ5; -.
DR   TreeFam; TF332736; -.
DR   BioGRID-ORCS; 68521; 4 hits in 73 CRISPR screens.
DR   PRO; PR:Q5HZJ5; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q5HZJ5; protein.
DR   Bgee; ENSMUSG00000032657; Expressed in lumbar dorsal root ganglion and 236 other tissues.
DR   ExpressionAtlas; Q5HZJ5; baseline and differential.
DR   Genevisible; Q5HZJ5; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050699; F:WW domain binding; ISO:MGI.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR030431; FAM189.
DR   PANTHER; PTHR17615; PTHR17615; 1.
DR   Pfam; PF04103; CD20; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..669
FT                   /note="Protein FAM189B"
FT                   /id="PRO_0000393335"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          387..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          445..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          550..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          597..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        476..491
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         359
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P81408"
FT   MOD_RES         390
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P81408"
FT   MOD_RES         494
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P81408"
FT   MOD_RES         575
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P81408"
FT   CARBOHYD        160
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   669 AA;  72016 MW;  092E34F205AFEDA2 CRC64;
     MMPSPSDSSR SLTSRPSTRG LTHLRLHRPW LQALLTLGLA QVLLGILVIT FSMVASSVTT
     TESIKRSCPS WAGFSLAFSG LVGIVSWKRP FTLVISFFSL LSVLCVMLSM AGSVLSCKNA
     QLARDFRECS MEGKVCVCCP PIPLHRPCPE WGQELKVALN STCDEARGAL KNLLFSVCGL
     TICAAIICTL SAIVCCVQIF SLDLVHMQLA PERSVSGPLG PLACTSSPPA PLLHTMLDLE
     EFVPPVPPPP YYPPEYTCSS ETDAQSITYN GSMDSPVPLY PTDCPPSYEA VMGLRRDSQA
     TLFDPQLHDG SCVCERVASI VDVSMDSGSL VLSAIGDLPG GSSPSEDSCL LELQGSVRSV
     DYVLFRSIQR SRAGYCLSLD CGLRGPFEDS PLPRRPPRAA RSYSCSAPEA PPPLGAPTAA
     RSCHRLEGWP PWVGPCFPEL RRRVPRGGSR SAAPPPARAP ARRFSDSSGS LTPPGHRPPH
     RTPPPPLLLP RSHSDPGITT SSDIADFRDL YTKVLEEEAA SVSSADTGLC SEACLFRLAR
     CPSPKLLRAR SAEKRRPVPT FQKVPLPSGP TPAHSLGDLK GSWPGRGLVT RFLQLSRRSP
     DPTGTGAHGY KQVRRSPWGR PGRESLHLRS CGDLSSGSSL RRLLSARRLE HGIRPHSLSL
     NGGSRETGL