ID   F193B_BOVIN             Reviewed;         823 AA.
AC   A7MB40; Q2HJB4;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Protein FAM193B;
GN   Name=FAM193B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Partly colocalized with an endoplasmic reticulum marker, HSP90B1.
CC       Shuttles between nucleus and cytoplasm (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A7MB40-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A7MB40-2; Sequence=VSP_034778, VSP_034779;
CC   -!- SIMILARITY: Belongs to the FAM193 family. {ECO:0000305}.
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DR   EMBL; BC113217; AAI13218.1; -; mRNA.
DR   EMBL; BC151322; AAI51323.1; -; mRNA.
DR   RefSeq; NP_001039898.2; NM_001046433.2. [A7MB40-1]
DR   AlphaFoldDB; A7MB40; -.
DR   SMR; A7MB40; -.
DR   STRING; 9913.ENSBTAP00000049740; -.
DR   PaxDb; A7MB40; -.
DR   PRIDE; A7MB40; -.
DR   Ensembl; ENSBTAT00000054949; ENSBTAP00000049740; ENSBTAG00000015192. [A7MB40-1]
DR   GeneID; 538655; -.
DR   KEGG; bta:538655; -.
DR   CTD; 54540; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015192; -.
DR   eggNOG; ENOG502QV04; Eukaryota.
DR   GeneTree; ENSGT00390000000973; -.
DR   HOGENOM; CLU_012556_0_0_1; -.
DR   InParanoid; A7MB40; -.
DR   OrthoDB; 171147at2759; -.
DR   TreeFam; TF330223; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000015192; Expressed in laryngeal cartilage and 104 other tissues.
DR   ExpressionAtlas; A7MB40; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   InterPro; IPR029717; FAM193.
DR   InterPro; IPR031802; FAM193_C.
DR   InterPro; IPR029722; FAM193B.
DR   PANTHER; PTHR15109; PTHR15109; 2.
DR   PANTHER; PTHR15109:SF3; PTHR15109:SF3; 2.
DR   Pfam; PF15914; FAM193_C; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..823
FT                   /note="Protein FAM193B"
FT                   /id="PRO_0000344456"
FT   REGION          1..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          158..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          503..583
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          599..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          422..484
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        25..40
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..279
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        503..546
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        557..574
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        645..673
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         694
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3U2K0"
FT   MOD_RES         706
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96PV7"
FT   MOD_RES         813
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96PV7"
FT   VAR_SEQ         1..374
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_034778"
FT   VAR_SEQ         375..425
FT                   /note="CQLPQPCEADEGLGEEEDSSSERSSCTSSSTHQRDGKFCDCCYCEFFGHNA
FT                   -> MKGGALGGIPGEPAVDHRDVDELLEFINSTEPKVPNSARAAKRARHKLKKK (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_034779"
SQ   SEQUENCE   823 AA;  88041 MW;  5BFFA5A1BFDE6A5A CRC64;
     MTRRRSRPSG GAGRRERARA TGPQKPQAPE PPPPPSLEAG AGAGPPEAPA EPYRDDPREE
     DEPKLAPGPQ VPPTTSQSVQ TCCLLCHRER KGWEEGPSQN GLVLQGEKLP PDFMPKLVKN
     LLGEMPLWVC QSCRKSMEED ERQTGREHAV AISLSHTSCK SQSCGGDSHS SSSSSSSSSS
     SSSSCHGNSG DWDPSSFLSA HKLSGLWNSP HSSGAMPGGS LGSPPTIPGE VFPISEHHRH
     SDLTAPPNSP TGHHPQPAPL IPSHPGSFGS PPHPHLLPTT PAVHFPAQVS ECPVAVAAAP
     HTPGPCQSPH LPSTSMPLLK MPPPFSGCSH PCSGHCSGHC SGPLLPPPSS QQLPSTHSRD
     PGCKGHKFTH SGLTCQLPQP CEADEGLGEE EDSSSERSSC TSSSTHQRDG KFCDCCYCEF
     FGHNAEKEKA QLAAEALKQA NRSVSGSREL RPARESLLGW PDRELDRVNS FLNSRLQEIK
     NTVKDSICAS FSMCELSVDS NGFSKEGATE PKPQSLAPSN PSGSSEQRPD INLDLSPLTL
     GSPQNHMLQA PGEPAPPWAE MRSPHPPWTE VKGPPPGIIP ENGLVRRLNT VPNLSRMIWV
     KTPKPGNPSS EEPSIKGAPG CKQELPEPVA SGGKPRKGKR QGNQAKKSEV SPASQSPACL
     ETPSAKGQTP SPKQPSKAPE PPRVDSCAEA GEGSQGTRPG PGWADSPKAD KEKGNSWRNW
     PGEAKARPLE QESVQPPGPA RPQSFQQGKG RSRRSRNKQE KSASSLDDVF LPKDMDGVEM
     DETDREVEYF KRFCLDSAKQ TRQKVAVNWT NFSLKKTTPS TAQ