F193B_MOUSE
ID F193B_MOUSE Reviewed; 892 AA.
AC Q3U2K0; Q69Z63; Q8K1B4; Q8VCA1;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein FAM193B;
GN Name=Fam193b; Synonyms=Kiaa1931;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=FVB/N; TISSUE=Brain, Eye, Kidney, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-764 AND SER-776, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Partly colocalized with an endoplasmic reticulum marker, HSP90B1.
CC Shuttles between nucleus and cytoplasm (By similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3U2K0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3U2K0-2; Sequence=VSP_034782;
CC Name=3;
CC IsoId=Q3U2K0-3; Sequence=VSP_034781;
CC -!- SIMILARITY: Belongs to the FAM193 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH25483.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD32581.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK173303; BAD32581.1; ALT_INIT; mRNA.
DR EMBL; AK040568; BAC30629.1; -; mRNA.
DR EMBL; AK155237; BAE33140.1; -; mRNA.
DR EMBL; AC126408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC021381; AAH21381.1; -; mRNA.
DR EMBL; BC023015; AAH23015.1; -; mRNA.
DR EMBL; BC025483; AAH25483.2; ALT_SEQ; mRNA.
DR CCDS; CCDS36678.1; -. [Q3U2K0-2]
DR RefSeq; NP_663357.2; NM_145382.4. [Q3U2K0-2]
DR RefSeq; XP_006517257.1; XM_006517194.3. [Q3U2K0-1]
DR RefSeq; XP_006517260.1; XM_006517197.1. [Q3U2K0-2]
DR RefSeq; XP_011242807.1; XM_011244505.1. [Q3U2K0-2]
DR AlphaFoldDB; Q3U2K0; -.
DR SMR; Q3U2K0; -.
DR STRING; 10090.ENSMUSP00000021957; -.
DR iPTMnet; Q3U2K0; -.
DR PhosphoSitePlus; Q3U2K0; -.
DR EPD; Q3U2K0; -.
DR MaxQB; Q3U2K0; -.
DR PaxDb; Q3U2K0; -.
DR PeptideAtlas; Q3U2K0; -.
DR PRIDE; Q3U2K0; -.
DR ProteomicsDB; 275720; -. [Q3U2K0-1]
DR ProteomicsDB; 275721; -. [Q3U2K0-2]
DR ProteomicsDB; 275722; -. [Q3U2K0-3]
DR Antibodypedia; 29329; 39 antibodies from 18 providers.
DR DNASU; 212483; -.
DR Ensembl; ENSMUST00000021957; ENSMUSP00000021957; ENSMUSG00000021495. [Q3U2K0-2]
DR GeneID; 212483; -.
DR KEGG; mmu:212483; -.
DR UCSC; uc007qrp.2; mouse. [Q3U2K0-3]
DR UCSC; uc011yzv.1; mouse. [Q3U2K0-1]
DR CTD; 54540; -.
DR MGI; MGI:2385851; Fam193b.
DR VEuPathDB; HostDB:ENSMUSG00000021495; -.
DR eggNOG; ENOG502QV04; Eukaryota.
DR GeneTree; ENSGT00390000000973; -.
DR HOGENOM; CLU_012556_0_0_1; -.
DR InParanoid; Q3U2K0; -.
DR OrthoDB; 171147at2759; -.
DR PhylomeDB; Q3U2K0; -.
DR TreeFam; TF330223; -.
DR BioGRID-ORCS; 212483; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Fam193b; mouse.
DR PRO; PR:Q3U2K0; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q3U2K0; protein.
DR Bgee; ENSMUSG00000021495; Expressed in retinal neural layer and 250 other tissues.
DR ExpressionAtlas; Q3U2K0; baseline and differential.
DR Genevisible; Q3U2K0; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR InterPro; IPR029717; FAM193.
DR InterPro; IPR031802; FAM193_C.
DR InterPro; IPR029722; FAM193B.
DR PANTHER; PTHR15109; PTHR15109; 1.
DR PANTHER; PTHR15109:SF3; PTHR15109:SF3; 1.
DR Pfam; PF15914; FAM193_C; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..892
FT /note="Protein FAM193B"
FT /id="PRO_0000344458"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 485..517
FT /evidence="ECO:0000255"
FT COMPBIAS 27..41
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..262
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..284
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..320
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 764
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 776
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 882
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96PV7"
FT VAR_SEQ 1..449
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_034781"
FT VAR_SEQ 1..114
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15368895,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:16141072"
FT /id="VSP_034782"
SQ SEQUENCE 892 AA; 95084 MW; A56A7499A4D9E5F0 CRC64;
MTRRRSRPSG GAGRRERARA AGLQKPQAPE PQPPPPSLEA GAGAGPPEVP AELDCDGPRE
EEEPKLAPGP QVPPTSSQSV QTCCLLCHRE RKGWEEGPSQ NGLVLQGEKL PPDFMPKLVK
NLLGEMPLWV CQSCRKSMEE EERQTGGDHA VAISLSHTSC KSQSCGGDSH SSSSSSSSSS
SSSSSCHGNS GDWDPSSFLS AHKLSGLWNS PHSSGAVPGS SLGSPPAILG EAFPVSEHHQ
HSDLTAPPNS PTGPPPHPAS LIPSHPGSFS SASYPPPLPT TPVAPFPAQA SECPMAAATA
THPSGPCQSP HPPSTSMPLL KMPPPLSGCS HPCSGHCSGH CGGPLLPPPS SQPLPSTHSR
DPGCKGHKFA HSGLACEADE GLGEEEDSSS ERSSCTSSST HPRDGKFCDC CYCEFFGHNA
PLAAPTSRNY TEIREKLRSR LTRRKEELPM KGGTLGGIPG EPAVDHRDVD ELLEFINSTE
PKVPNSARAA KRARHKLKKK EKEKARLATE ALKQVNRVSG SQEPRPARER LLEWPDQELD
RVNSFLSSRL QEIKSTVKDS LCASLSMCEL SVESSGFKEG TVEAQTLTPS DLSGSSQKRP
DINLDLSPLT LGSPQSHTLQ APSEPVPPWA ERRDPHPPPW TEVRGPPPGI PENGLVRRLN
TVPNLSRVIW VKTPKPGNPS SEESSKEVPS CKQELSEPVA TGGKPKKSKR QGSQAKKTLA
SPAPWSPANL EASGAKSQVS SPKQPSKGSE PAKVGSGAEP GEGSPGSRPG PIQADSPKTD
KKGSSWQNWP GGAKARTLEQ ESEQTPGPAR PQSLSQGKGR SRRSRNKQEK SASSLDDVFL
PKDLDGVEMD ETDREVEYFK RFCLDSAKQT RQKVAVNWTN FSLKKTTPST AQ
