F199X_HUMAN
ID F199X_HUMAN Reviewed; 388 AA.
AC Q6PEV8; Q8WVP6; Q96AV3;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Protein FAM199X;
GN Name=FAM199X; Synonyms=CXorf39;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 158-388 (ISOFORM 2).
RC TISSUE=Bone, Pancreas, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316 AND SER-321, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q6PEV8; P61964: WDR5; NbExp=4; IntAct=EBI-4280426, EBI-540834;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PEV8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PEV8-2; Sequence=VSP_020747;
CC -!- SIMILARITY: Belongs to the FAM199 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL049631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL135959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016683; AAH16683.1; -; mRNA.
DR EMBL; BC017665; AAH17665.2; -; mRNA.
DR EMBL; BC057847; AAH57847.1; -; mRNA.
DR CCDS; CCDS35364.1; -. [Q6PEV8-1]
DR RefSeq; NP_997201.1; NM_207318.3. [Q6PEV8-1]
DR RefSeq; XP_005262136.1; XM_005262079.2. [Q6PEV8-2]
DR AlphaFoldDB; Q6PEV8; -.
DR SMR; Q6PEV8; -.
DR BioGRID; 126553; 18.
DR IntAct; Q6PEV8; 13.
DR MINT; Q6PEV8; -.
DR STRING; 9606.ENSP00000417581; -.
DR iPTMnet; Q6PEV8; -.
DR PhosphoSitePlus; Q6PEV8; -.
DR BioMuta; FAM199X; -.
DR DMDM; 74749168; -.
DR EPD; Q6PEV8; -.
DR jPOST; Q6PEV8; -.
DR MassIVE; Q6PEV8; -.
DR MaxQB; Q6PEV8; -.
DR PaxDb; Q6PEV8; -.
DR PeptideAtlas; Q6PEV8; -.
DR PRIDE; Q6PEV8; -.
DR ProteomicsDB; 67080; -. [Q6PEV8-1]
DR ProteomicsDB; 67081; -. [Q6PEV8-2]
DR Antibodypedia; 512; 13 antibodies from 8 providers.
DR DNASU; 139231; -.
DR Ensembl; ENST00000493442.2; ENSP00000417581.1; ENSG00000123575.9. [Q6PEV8-1]
DR GeneID; 139231; -.
DR KEGG; hsa:139231; -.
DR MANE-Select; ENST00000493442.2; ENSP00000417581.1; NM_207318.4; NP_997201.1.
DR UCSC; uc004elw.4; human. [Q6PEV8-1]
DR CTD; 139231; -.
DR GeneCards; FAM199X; -.
DR HGNC; HGNC:25195; FAM199X.
DR HPA; ENSG00000123575; Low tissue specificity.
DR neXtProt; NX_Q6PEV8; -.
DR OpenTargets; ENSG00000123575; -.
DR PharmGKB; PA165756587; -.
DR VEuPathDB; HostDB:ENSG00000123575; -.
DR eggNOG; ENOG502QR59; Eukaryota.
DR GeneTree; ENSGT00440000033895; -.
DR HOGENOM; CLU_061935_0_0_1; -.
DR InParanoid; Q6PEV8; -.
DR OMA; NCGSTSG; -.
DR PhylomeDB; Q6PEV8; -.
DR PathwayCommons; Q6PEV8; -.
DR SignaLink; Q6PEV8; -.
DR BioGRID-ORCS; 139231; 11 hits in 707 CRISPR screens.
DR ChiTaRS; FAM199X; human.
DR GenomeRNAi; 139231; -.
DR Pharos; Q6PEV8; Tdark.
DR PRO; PR:Q6PEV8; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q6PEV8; protein.
DR Bgee; ENSG00000123575; Expressed in oviduct epithelium and 197 other tissues.
DR ExpressionAtlas; Q6PEV8; baseline and differential.
DR Genevisible; Q6PEV8; HS.
DR InterPro; IPR029672; FAM199X_fam.
DR PANTHER; PTHR32003; PTHR32003; 1.
DR Pfam; PF15814; FAM199X; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..388
FT /note="Protein FAM199X"
FT /id="PRO_0000251210"
FT REGION 288..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 316
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 321
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VAR_SEQ 290..332
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020747"
SQ SEQUENCE 388 AA; 42801 MW; F08D56A0D5C60B21 CRC64;
MSDEASAITS YEKFLTPEEP FPLLGPPRGV GTCPSEEPGC LDISDFGCQL SSCHRTDPLH
RFHTNRWNLT SCGTSVASSE GSEELFSSVS VGDQDDCYSL LDDQDFTSFD LFPEGSVCSD
VSSSISTYWD WSDSEFEWQL PGSDIASGSD VLSDVIPSIP SSPCLLPKKK NKHRNLDELP
WSAMTNDEQV EYIEYLSRKV STEMGLREQL DIIKIIDPSA QISPTDSEFI IELNCLTDEK
LKQVRNYIKE HSPRQRPARE AWKRSNFSCA STSGVSGASA SASSSSASMV SSASSSGSSV
GNSASNSSAN MSRAHSDSNL SASAAERIRD SKKRSKQRKL QQKAFRKRQL KEQRQARKER
LSGLFLNEEV LSLKVTEEDH EADVDVLM
