ID   F1_RABPU                Reviewed;         227 AA.
AC   Q6RZR2;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   29-SEP-2021, entry version 42.
DE   RecName: Full=Protein F1;
GN   OrderedLocusNames=RPXV029;
OS   Rabbitpox virus (strain Utrecht) (RPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=45417;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16227218; DOI=10.1099/vir.0.81331-0;
RA   Li G., Chen N., Roper R.L., Feng Z., Hunter A.L., Danila M.,
RA   Lefkowitz E.J., Buller R.M.L., Upton C.;
RT   "Complete coding sequences of the rabbitpox virus genome.";
RL   J. Gen. Virol. 86:2969-2977(2005).
CC   -!- FUNCTION: Protein with a BCL2-like fold which is essential for survival
CC       of infected cells. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with host pro-apoptotic protein BCL2L11
CC       (via BH3 domain) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae F1 protein family. {ECO:0000305}.
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DR   EMBL; AY484669; AAS49742.1; -; Genomic_DNA.
DR   SMR; Q6RZR2; -.
DR   MEROPS; I91.001; -.
DR   PRIDE; Q6RZR2; -.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR011207; Orthopox_F1.
DR   InterPro; IPR021119; Poxvirus_F1/C10.
DR   Pfam; PF11099; M11L; 1.
DR   PIRSF; PIRSF015971; VAC_F1L; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction;
KW   Inhibition of host apoptosis by viral BCL2-like protein;
KW   Modulation of host cell apoptosis by virus.
FT   CHAIN           1..227
FT                   /note="Protein F1"
FT                   /id="PRO_0000099477"
SQ   SEQUENCE   227 AA;  26527 MW;  C96CCC36B481D885 CRC64;
     MLSMFMYNNI VDYVDDIDNG IVQDIEDEAS NNVDHDYVYP LPENMVYRFD KSTNILDYLS
     TERDHVMMAV RYYMSKQRLD DLYRQLPTKT RSYIDIINIY CDKVSNDYNR DMNIIHDMAS
     TESFTVYDIN NEVNTMLMDN KGLGVRLATI SFITELGRRC MNPVETIKMF TLLSHTICDD
     CFVDYITDIS TPRDNATTNS STREYLKLMG IAVIMFATYK TLKYMIG