ID   F1_VACCC                Reviewed;         226 AA.
AC   P68450; P21091;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   29-SEP-2021, entry version 48.
DE   RecName: Full=Protein F1;
GN   ORFNames=F1L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Protein with a BCL2-like fold which is essential for survival
CC       of infected cells. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with host pro-apoptotic protein BCL2L11
CC       (via BH3 domain) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae F1 protein family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48014.1; -; Genomic_DNA.
DR   PIR; F42506; F42506.
DR   SMR; P68450; -.
DR   MEROPS; I91.001; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR011207; Orthopox_F1.
DR   InterPro; IPR021119; Poxvirus_F1/C10.
DR   Pfam; PF11099; M11L; 1.
DR   PIRSF; PIRSF015971; VAC_F1L; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction;
KW   Inhibition of host apoptosis by viral BCL2-like protein;
KW   Modulation of host cell apoptosis by virus; Reference proteome.
FT   CHAIN           1..226
FT                   /note="Protein F1"
FT                   /id="PRO_0000099473"
SQ   SEQUENCE   226 AA;  26367 MW;  CC945EB188C1AC39 CRC64;
     MLSMFMCNNI VDYVDDIDNG IVQDIEDEAS NNVDHDYVYP LPENMVYRFD KSTNILDYLS
     TERDHVMMAV RYYMSKQRLD DLYRQLPTKT RSYIDIINIY CDKVSNDYNR DMNIMYDMAS
     TKSFTVYDIN NEVNTILMDN KGLGVRLATI SFITELGRRC MNPVKTIKMF TLLSHTICDD
     CFVDYITDIS PPDNTIPNTS TREYLKLIGI TAIMFATYKT LKYMIG