ID   F1_VACCP                Reviewed;         206 AA.
AC   P68451; P21091;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   29-SEP-2021, entry version 39.
DE   RecName: Full=Protein F1;
DE   Flags: Fragment;
GN   ORFNames=F1L;
OS   Vaccinia virus (strain L-IVP) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=31531;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Mikryukov N.N., Chizhikov V.E., Prikhod'Ko G.G., Urmmanov I.M.,
RA   Serpinskii O.I., Blinov V.M., Nikulin A.E., Vasilenko S.K.;
RT   "Structural-functional organization of segment of vaccinia virus genome.";
RL   Biotekhnologiya 4:442-449(1988).
CC   -!- FUNCTION: Protein with a BCL2-like fold which is essential for survival
CC       of infected cells. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with host pro-apoptotic protein BCL2L11
CC       (via BH3 domain) (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       P68451; O43521: BCL2L11; Xeno; NbExp=4; IntAct=EBI-7066119, EBI-526406;
CC   -!- SIMILARITY: Belongs to the poxviridae F1 protein family. {ECO:0000305}.
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DR   EMBL; M57977; AAA48297.1; -; Genomic_DNA.
DR   SMR; P68451; -.
DR   IntAct; P68451; 11.
DR   MINT; P68451; -.
DR   MEROPS; I91.001; -.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:InterPro.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR011207; Orthopox_F1.
DR   InterPro; IPR021119; Poxvirus_F1/C10.
DR   Pfam; PF11099; M11L; 1.
DR   PIRSF; PIRSF015971; VAC_F1L; 1.
PE   1: Evidence at protein level;
FT   CHAIN           1..>206
FT                   /note="Protein F1"
FT                   /id="PRO_0000099474"
FT   VARIANT         206
FT                   /note="K -> S"
FT   NON_TER         206
SQ   SEQUENCE   206 AA;  24136 MW;  A38AFE4A5DA57CC3 CRC64;
     MLSMFMCNNI VDYVDDIDNG IVQDIEDEAS NNVDHDYVYP LPENMVYRFD KSTNILDYLS
     TERDHVMMAV RYYMSKQRLD DLYRQLPTKT RSYIDIINIY CDKVSNDYNR DMNIMYDMAS
     TKSFTVYDIN NEVNTILMDN KGLGVRLATI SFITELGRRC MNPVKTIKMF TLLSHTICDD
     CFVDYITDIS PPDNTIPNTS TREYLK