ID   F1_VACCT                Reviewed;         226 AA.
AC   Q9JFF2;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Protein F1;
GN   ORFNames=TF1L;
OS   Vaccinia virus (strain Tian Tan) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10253;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Jin Q., Hou Y.D., Cheng N.H., Yao E.M., Cheng S.X., Yang X.K., Jing D.Y.,
RA   Yu W.H., Yuan J.S., Ma X.J.;
RT   "Complete genomic sequence of vaccinia virus (Tian Tan strain).";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protein with a BCL2-like fold which is essential for survival
CC       of infected cells. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with host pro-apoptotic protein BCL2L11
CC       (via BH3 domain) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae F1 protein family. {ECO:0000305}.
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DR   EMBL; AF095689; AAF33891.1; -; Genomic_DNA.
DR   SMR; Q9JFF2; -.
DR   MEROPS; I91.001; -.
DR   Proteomes; UP000163220; Genome.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR011207; Orthopox_F1.
DR   InterPro; IPR021119; Poxvirus_F1/C10.
DR   Pfam; PF11099; M11L; 1.
DR   PIRSF; PIRSF015971; VAC_F1L; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction;
KW   Inhibition of host apoptosis by viral BCL2-like protein;
KW   Modulation of host cell apoptosis by virus.
FT   CHAIN           1..226
FT                   /note="Protein F1"
FT                   /id="PRO_0000099475"
SQ   SEQUENCE   226 AA;  26386 MW;  5B7D504A8F21B9D6 CRC64;
     MLSMFMCNNI VDYVDDIDNG IVQDIEDEAS NNVDRDYVYP LPENMVYRFD KSTNILDYLS
     TERDHVMMAV RYYMSKQRLD DLYRQLPTKT RSYIDIINIY CDKVSNDYNR DMNIMYDMAS
     TKSFTVYDIN NEVNTILMDN KGLGVRLATI SFITELGRRC MNPVKTIKMF TLLSHTICDD
     CFVDYITDIS PPDNTIPNTS TREYLKLIGI TAIMFATYKT LKYMIG