F200A_HUMAN
ID F200A_HUMAN Reviewed; 573 AA.
AC Q8TCP9; A4D293; A8K3V9; B2RD92; C9J6A8; D6W5T2; Q8N9P3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Protein FAM200A;
GN Name=FAM200A; Synonyms=C7orf38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary cancer;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adrenal gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TCP9; Q14498-3: RBM39; NbExp=3; IntAct=EBI-2799179, EBI-6654703;
CC Q8TCP9; Q3MIN7: RGL3; NbExp=3; IntAct=EBI-2799179, EBI-2856274;
CC Q8TCP9; G2XKQ0: SUMO1P1; NbExp=3; IntAct=EBI-2799179, EBI-10175576;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM200 family. {ECO:0000305}.
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DR EMBL; AL713672; CAD28478.1; -; mRNA.
DR EMBL; AK290724; BAF83413.1; -; mRNA.
DR EMBL; AK315452; BAG37839.1; -; mRNA.
DR EMBL; AC005020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236956; EAL23872.1; -; Genomic_DNA.
DR EMBL; CH471091; EAW76652.1; -; Genomic_DNA.
DR EMBL; CH471091; EAW76653.1; -; Genomic_DNA.
DR EMBL; BC040214; AAH40214.1; -; mRNA.
DR EMBL; BC126337; AAI26338.1; -; mRNA.
DR EMBL; BC130371; AAI30372.1; -; mRNA.
DR EMBL; AK094113; BAC04288.1; -; mRNA.
DR CCDS; CCDS5668.1; -.
DR RefSeq; NP_659802.1; NM_145111.3.
DR RefSeq; XP_011514213.1; XM_011515911.2.
DR RefSeq; XP_011514215.1; XM_011515913.2.
DR AlphaFoldDB; Q8TCP9; -.
DR BioGRID; 128754; 12.
DR IntAct; Q8TCP9; 6.
DR MINT; Q8TCP9; -.
DR STRING; 9606.ENSP00000411372; -.
DR iPTMnet; Q8TCP9; -.
DR PhosphoSitePlus; Q8TCP9; -.
DR BioMuta; FAM200A; -.
DR DMDM; 74730599; -.
DR EPD; Q8TCP9; -.
DR MassIVE; Q8TCP9; -.
DR PaxDb; Q8TCP9; -.
DR PeptideAtlas; Q8TCP9; -.
DR PRIDE; Q8TCP9; -.
DR ProteomicsDB; 74149; -.
DR Antibodypedia; 21644; 75 antibodies from 17 providers.
DR DNASU; 221786; -.
DR Ensembl; ENST00000449309.2; ENSP00000411372.1; ENSG00000221909.3.
DR GeneID; 221786; -.
DR KEGG; hsa:221786; -.
DR MANE-Select; ENST00000449309.2; ENSP00000411372.1; NM_145111.4; NP_659802.1.
DR UCSC; uc003ura.4; human.
DR CTD; 221786; -.
DR DisGeNET; 221786; -.
DR GeneCards; FAM200A; -.
DR HGNC; HGNC:25401; FAM200A.
DR HPA; ENSG00000221909; Low tissue specificity.
DR neXtProt; NX_Q8TCP9; -.
DR OpenTargets; ENSG00000221909; -.
DR PharmGKB; PA165618089; -.
DR VEuPathDB; HostDB:ENSG00000221909; -.
DR eggNOG; ENOG502SICS; Eukaryota.
DR GeneTree; ENSGT00940000164024; -.
DR HOGENOM; CLU_021316_5_0_1; -.
DR InParanoid; Q8TCP9; -.
DR OMA; NCKGISS; -.
DR OrthoDB; 875619at2759; -.
DR PhylomeDB; Q8TCP9; -.
DR TreeFam; TF328297; -.
DR PathwayCommons; Q8TCP9; -.
DR SignaLink; Q8TCP9; -.
DR BioGRID-ORCS; 221786; 10 hits in 1070 CRISPR screens.
DR GeneWiki; FAM200A; -.
DR GenomeRNAi; 221786; -.
DR Pharos; Q8TCP9; Tdark.
DR PRO; PR:Q8TCP9; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8TCP9; protein.
DR Bgee; ENSG00000221909; Expressed in cortical plate and 163 other tissues.
DR ExpressionAtlas; Q8TCP9; baseline and differential.
DR Genevisible; Q8TCP9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR012337; RNaseH-like_sf.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..573
FT /note="Protein FAM200A"
FT /id="PRO_0000279405"
FT TOPO_DOM 1..513
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..533
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 534..573
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 125
FT /note="H -> R (in Ref. 2; BAF83413)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="N -> S (in Ref. 2; BAG37839)"
FT /evidence="ECO:0000305"
FT CONFLICT 319
FT /note="E -> G (in Ref. 2; BAF83413)"
FT /evidence="ECO:0000305"
FT CONFLICT 330
FT /note="H -> L (in Ref. 2; BAC04288)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 573 AA; 66276 MW; C19CC28D9C36FCF0 CRC64;
MTPESRDTTD LSPGGTQEME GIVIVKVEEE DEEDHFQKER NKVESSPQVL SRSTTMNERA
LLSSYLVAYR VAKEKMAHTA AEKIILPACM DMVRTIFDDK SADKLRTIPL SDNTISRRIC
TIAKHLEAML ITRLQSGIDF AIQLDESTDI ASCPTLLVYV RYVWQDDFVE DLLCCLNLNS
HITGLDLFTE LENCLLGQYK LNWKHCKGIS SDGTANMTGK HSRLTEKLLE ATHNNAVWNH
CFIHREALVS KEISPSLMDV LKNAVKTVNF IKGSSLNSRL LEIFCSEIGV NHTHLLFHTE
VRWLSQGKVL SRVYELRNEI YIFLVEKQSH LANIFEDDIW VTKLAYLSDI FGILNELSLK
MQGKNNDIFQ YLEHILGFQK TLLLWQARLK SNRPSYYMFP TLLQHIEENI INEDCLKEIK
LEILLHLTSL SQTFNYYFPE EKFESLKENI WMKDPFAFQN PESIIELNLE PEEENELLQL
SSSFTLKNYY KILSLSAFWI KIKDDFPLLS RKSILLLLPF TTTYLCELGF SILTRLKTKK
RNRLNSAPDM RVALSSCVPD WKELMNRQAH PSH
