ID   F200B_HUMAN             Reviewed;         657 AA.
AC   P0CF97;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Protein FAM200B {ECO:0000305};
GN   Name=FAM200B {ECO:0000312|HGNC:HGNC:27740};
GN   Synonyms=C4orf53 {ECO:0000312|HGNC:HGNC:27740};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- SIMILARITY: Belongs to the FAM200 family. {ECO:0000305}.
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DR   EMBL; AC114744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS47028.1; -.
DR   RefSeq; NP_001138663.1; NM_001145191.1.
DR   RefSeq; XP_016863537.1; XM_017008048.1.
DR   AlphaFoldDB; P0CF97; -.
DR   BioGRID; 130142; 2.
DR   STRING; 9606.ENSP00000483930; -.
DR   iPTMnet; P0CF97; -.
DR   PhosphoSitePlus; P0CF97; -.
DR   BioMuta; FAM200B; -.
DR   DMDM; 296439620; -.
DR   MassIVE; P0CF97; -.
DR   PaxDb; P0CF97; -.
DR   PeptideAtlas; P0CF97; -.
DR   PRIDE; P0CF97; -.
DR   ProteomicsDB; 52445; -.
DR   DNASU; 285550; -.
DR   Ensembl; ENST00000422728.3; ENSP00000393017.2; ENSG00000237765.8.
DR   GeneID; 285550; -.
DR   KEGG; hsa:285550; -.
DR   MANE-Select; ENST00000422728.3; ENSP00000393017.2; NM_001145191.2; NP_001138663.1.
DR   UCSC; uc003gof.5; human.
DR   CTD; 285550; -.
DR   DisGeNET; 285550; -.
DR   GeneCards; FAM200B; -.
DR   HGNC; HGNC:27740; FAM200B.
DR   HPA; ENSG00000237765; Low tissue specificity.
DR   neXtProt; NX_P0CF97; -.
DR   OpenTargets; ENSG00000237765; -.
DR   PharmGKB; PA165664101; -.
DR   VEuPathDB; HostDB:ENSG00000237765; -.
DR   eggNOG; ENOG502QT83; Eukaryota.
DR   GeneTree; ENSGT00940000164387; -.
DR   HOGENOM; CLU_021316_5_0_1; -.
DR   InParanoid; P0CF97; -.
DR   OMA; YYMFPRF; -.
DR   OrthoDB; 875619at2759; -.
DR   PhylomeDB; P0CF97; -.
DR   TreeFam; TF328297; -.
DR   PathwayCommons; P0CF97; -.
DR   SignaLink; P0CF97; -.
DR   BioGRID-ORCS; 285550; 52 hits in 1038 CRISPR screens.
DR   ChiTaRS; FAM200B; human.
DR   GenomeRNAi; 285550; -.
DR   Pharos; P0CF97; Tdark.
DR   PRO; PR:P0CF97; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; P0CF97; protein.
DR   Bgee; ENSG00000237765; Expressed in monocyte and 176 other tissues.
DR   ExpressionAtlas; P0CF97; baseline and differential.
DR   Genevisible; P0CF97; HS.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..657
FT                   /note="Protein FAM200B"
FT                   /id="PRO_0000394262"
SQ   SEQUENCE   657 AA;  76034 MW;  BCAD05E23FEFD376 CRC64;
     MDHFFIKRKR NSEVKYTEAC SSSSVESGIV NSDNIEKNTD SNLQTSTSFE PHFKKKKVSA
     RRYNEDYLKY GFIKCEKPFE NDRPQCVICN NILANESLKP SKLKRHLETQ HAELIDKPLE
     YFQRKKKDIK LSTQFLSCST AVSEKALLSS YLVAYRVAKE KIANTAAEKI ILPACLDMVR
     TIFDDKSADK LKTIPNDNTV SLRICTIAEH LETMLITRLQ SGIDFAIQLD ESTDIGSCTT
     LLVYVRYAWQ DDFLEDFLCF LNLTSHLSGL DIFTELERRI VGQYKLNWKN CKGITSDGTA
     TMTGKHSRVI KKLLEVTNNG AVWNHCFIHR EGLASREIPQ NLMEVLKNAV KVVNFIKGSS
     LNSRLLETFC SEIGTNHTHL LYHTKIRWLS QGKILSRVYE LRNEIHFFLI EKKSHLASIF
     EDDTWVTKLA YLTDIFSILN ELSLKLQGKN SDVFQHVERI QGFRKTLLLW QVRLKSNRPS
     YYMFPRFLQH IEENIINENI LKEIKLEILL HLTSLSQTFN HFFPEEKFET LRENSWVKDP
     FAFRHPESII ELNLVPEEEN ELLQLSSSYT LKNDYETLSL SAFWMKVKED FPLLSRKSVL
     LLLPFTTTSL CELGFSILTQ LKTKERNGLN CAAVMRVALS SCVPDWNELM NRQAHPS