F204A_HUMAN
ID F204A_HUMAN Reviewed; 233 AA.
AC Q9H8W3; D3DRC6; Q5T373; Q9H5V5;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Protein FAM204A;
GN Name=FAM204A; Synonyms=C10orf84;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9H8W3; Q14192: FHL2; NbExp=3; IntAct=EBI-8465160, EBI-701903;
CC Q9H8W3; O60341: KDM1A; NbExp=3; IntAct=EBI-8465160, EBI-710124;
CC Q9H8W3; Q8NB12: SMYD1; NbExp=4; IntAct=EBI-8465160, EBI-8463848;
CC Q9H8W3; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-8465160, EBI-12023934;
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DR EMBL; AK023250; BAB14487.1; -; mRNA.
DR EMBL; AK026630; BAB15514.1; -; mRNA.
DR EMBL; AL365498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471066; EAW49417.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49418.1; -; Genomic_DNA.
DR EMBL; BC023577; AAH23577.1; -; mRNA.
DR CCDS; CCDS7605.1; -.
DR RefSeq; NP_001128144.1; NM_001134672.1.
DR RefSeq; NP_071346.1; NM_022063.2.
DR AlphaFoldDB; Q9H8W3; -.
DR SMR; Q9H8W3; -.
DR BioGRID; 121970; 21.
DR IntAct; Q9H8W3; 7.
DR MINT; Q9H8W3; -.
DR STRING; 9606.ENSP00000358183; -.
DR iPTMnet; Q9H8W3; -.
DR PhosphoSitePlus; Q9H8W3; -.
DR BioMuta; FAM204A; -.
DR DMDM; 50400654; -.
DR EPD; Q9H8W3; -.
DR jPOST; Q9H8W3; -.
DR MassIVE; Q9H8W3; -.
DR MaxQB; Q9H8W3; -.
DR PaxDb; Q9H8W3; -.
DR PeptideAtlas; Q9H8W3; -.
DR PRIDE; Q9H8W3; -.
DR ProteomicsDB; 81248; -.
DR Antibodypedia; 49195; 28 antibodies from 12 providers.
DR DNASU; 63877; -.
DR Ensembl; ENST00000369172.8; ENSP00000358170.4; ENSG00000165669.14.
DR Ensembl; ENST00000369183.9; ENSP00000358183.4; ENSG00000165669.14.
DR GeneID; 63877; -.
DR KEGG; hsa:63877; -.
DR MANE-Select; ENST00000369183.9; ENSP00000358183.4; NM_022063.3; NP_071346.1.
DR UCSC; uc001ldo.3; human.
DR CTD; 63877; -.
DR GeneCards; FAM204A; -.
DR HGNC; HGNC:25794; FAM204A.
DR HPA; ENSG00000165669; Low tissue specificity.
DR neXtProt; NX_Q9H8W3; -.
DR OpenTargets; ENSG00000165669; -.
DR PharmGKB; PA134910767; -.
DR VEuPathDB; HostDB:ENSG00000165669; -.
DR eggNOG; ENOG502S9J9; Eukaryota.
DR GeneTree; ENSGT00390000008978; -.
DR HOGENOM; CLU_102986_0_0_1; -.
DR InParanoid; Q9H8W3; -.
DR OMA; KNREMKM; -.
DR OrthoDB; 1616998at2759; -.
DR PhylomeDB; Q9H8W3; -.
DR TreeFam; TF328607; -.
DR PathwayCommons; Q9H8W3; -.
DR SignaLink; Q9H8W3; -.
DR BioGRID-ORCS; 63877; 70 hits in 1078 CRISPR screens.
DR ChiTaRS; FAM204A; human.
DR GenomeRNAi; 63877; -.
DR Pharos; Q9H8W3; Tdark.
DR PRO; PR:Q9H8W3; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q9H8W3; protein.
DR Bgee; ENSG00000165669; Expressed in calcaneal tendon and 181 other tissues.
DR ExpressionAtlas; Q9H8W3; baseline and differential.
DR Genevisible; Q9H8W3; HS.
DR InterPro; IPR037690; FAM204A.
DR PANTHER; PTHR14386; PTHR14386; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..233
FT /note="Protein FAM204A"
FT /id="PRO_0000089808"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 144..164
FT /evidence="ECO:0000255"
FT COMPBIAS 31..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 68
FT /note="C -> F (in Ref. 1; BAB15514)"
FT /evidence="ECO:0000305"
FT CONFLICT 84
FT /note="H -> R (in Ref. 1; BAB15514)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 233 AA; 27021 MW; 53F9EA7A560F70FB CRC64;
MWSGLLPPGL NESDAESNSE DEATLENSGL NLQEDKEDES IRKTEIIDFS TDEPKTETES
NVNAYEECPS GIPIDMWNKF QELHKKHSEQ KSTTSRFRGK RRKRSRKDKL KNEKELHSEP
SSNETQWKEL TQYFGVNDRF DPPVKRKKVE KSGLEKRIDQ AVEEWNIEKA EELSNQLATR
ELGVKIAKAV ACHNFVKAKK EVENSQAARK KKKLAWGFEA KKRWETKSNM GYM
