F205A_HUMAN
ID F205A_HUMAN Reviewed; 1335 AA.
AC Q6ZU69; A8MVW7;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 4.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein FAM205A;
GN Name=FAM205A; Synonyms=C9orf144B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM205 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC86357.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK125949; BAC86357.1; ALT_INIT; mRNA.
DR EMBL; DC402575; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; DC404169; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL162231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS55305.1; -.
DR RefSeq; NP_001135389.1; NM_001141917.1.
DR AlphaFoldDB; Q6ZU69; -.
DR SMR; Q6ZU69; -.
DR IntAct; Q6ZU69; 3.
DR STRING; 9606.ENSP00000417711; -.
DR iPTMnet; Q6ZU69; -.
DR PhosphoSitePlus; Q6ZU69; -.
DR BioMuta; FAM205A; -.
DR DMDM; 206729931; -.
DR jPOST; Q6ZU69; -.
DR MassIVE; Q6ZU69; -.
DR PaxDb; Q6ZU69; -.
DR PeptideAtlas; Q6ZU69; -.
DR PRIDE; Q6ZU69; -.
DR ProteomicsDB; 68320; -.
DR Antibodypedia; 20893; 17 antibodies from 8 providers.
DR DNASU; 259308; -.
DR Ensembl; ENST00000378788.4; ENSP00000417711.1; ENSG00000205108.6.
DR GeneID; 259308; -.
DR KEGG; hsa:259308; -.
DR MANE-Select; ENST00000378788.4; ENSP00000417711.1; NM_001141917.2; NP_001135389.1.
DR UCSC; uc011lor.3; human.
DR CTD; 259308; -.
DR GeneCards; FAM205A; -.
DR HGNC; HGNC:41911; FAM205A.
DR HPA; ENSG00000205108; Tissue enriched (testis).
DR neXtProt; NX_Q6ZU69; -.
DR OpenTargets; ENSG00000205108; -.
DR VEuPathDB; HostDB:ENSG00000205108; -.
DR eggNOG; ENOG502SM6T; Eukaryota.
DR GeneTree; ENSGT00950000183043; -.
DR HOGENOM; CLU_007854_0_1_1; -.
DR InParanoid; Q6ZU69; -.
DR OMA; PNTMASL; -.
DR OrthoDB; 270197at2759; -.
DR PhylomeDB; Q6ZU69; -.
DR TreeFam; TF339420; -.
DR PathwayCommons; Q6ZU69; -.
DR BioGRID-ORCS; 259308; 10 hits in 1060 CRISPR screens.
DR GenomeRNAi; 259308; -.
DR Pharos; Q6ZU69; Tdark.
DR PRO; PR:Q6ZU69; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q6ZU69; protein.
DR Bgee; ENSG00000205108; Expressed in left testis and 22 other tissues.
DR Genevisible; Q6ZU69; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR InterPro; IPR027970; DUF4599.
DR InterPro; IPR039509; SPATA31/FAM205.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1335
FT /note="Protein FAM205A"
FT /id="PRO_0000308581"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 403..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1248..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1082
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 345
FT /note="P -> S (in Ref. 1; BAC86357)"
FT /evidence="ECO:0000305"
FT CONFLICT 352
FT /note="F -> S (in Ref. 1; BAC86357)"
FT /evidence="ECO:0000305"
FT CONFLICT 499
FT /note="M -> V (in Ref. 1; BAC86357)"
FT /evidence="ECO:0000305"
FT CONFLICT 600
FT /note="L -> S (in Ref. 1; BAC86357)"
FT /evidence="ECO:0000305"
FT CONFLICT 602
FT /note="R -> H (in Ref. 1; BAC86357)"
FT /evidence="ECO:0000305"
FT CONFLICT 814
FT /note="E -> V (in Ref. 1; BAC86357)"
FT /evidence="ECO:0000305"
FT CONFLICT 999
FT /note="S -> I (in Ref. 1; BAC86357)"
FT /evidence="ECO:0000305"
FT CONFLICT 1046
FT /note="G -> E (in Ref. 1; BAC86357)"
FT /evidence="ECO:0000305"
FT CONFLICT 1060
FT /note="H -> Y (in Ref. 1; BAC86357)"
FT /evidence="ECO:0000305"
FT CONFLICT 1101
FT /note="R -> H (in Ref. 1; BAC86357)"
FT /evidence="ECO:0000305"
FT CONFLICT 1165
FT /note="A -> S (in Ref. 1; BAC86357)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1335 AA; 148096 MW; 394EE34D5854D8CA CRC64;
MLSPTFVLWE VGYPLYIYGS IFIVIVIIWQ VKRSHHELSS EPKRSCCRCH QKVRQRARDA
ASTARRRSRE EAEKPQKLLS IIKSQGWLPL ERSVRRILCA DPCCQICNSV ALEIQQLLVG
ENNQISLTLS GPLQGSSCLE MLSTSSMSLD QSLEFHSWHT RELSLSSVTP TLSQLTDQKS
LTQSAAQSTY ADGIQDYWAD HLQLGQEFQV PDVLRGPNTI ASSRIEKPRA PLNQEEMTQS
NPSLVQGNQG QHHLNSQVSL LSLNPETLNR MHPMALHMVL PAHLPFLSPE VLRLLEVHVK
KWMHFQRWGL PRRVEESLRQ LMPNPPLYYQ PGNDQPVSFN LKNTPQVSLH RFETISLQTW
CSCVAGQPIQ TFWVSEWSTM NPEQRHHCQQ TPNPMALALP SPALKALSGP HPQSGGQDND
SGSDLQQKYS QLFCGLPSLH SESLVATFMG SQGLPKIENV PKPPLKDPFL FNELSFPQLL
PKTSPQSAPP SSPLSPNWMS PSDHQRAQIN VPFLTLAEYE ALEWHLLQRQ LQLQWGWPAA
LQRSQHTQCL MQHEPCGKAQ SPETTTASQT GKSISVLTRE LLFFPEHARK LLEFHIQKQL
IRHRWGLPQK IQQSIQLLLT STDQQTVSSS STALANVSIP QPVALEANGA CDVLSPIAAP
VSIPRPHLLT QVKAILQSHI DSKCGQIHQG KIPACVHRSW DCRISGVLAV APFPCIPESQ
FLELQTASDP DLHHKVMPWM PTALDQQQQA LPGTVTEHPK LLRVLSVEAI EKLETTLRHK
HLAFLSGLPA LYYVALPRAL APAVTSQSVI TEMEPSPVEI PAEPLIQMVS FEEQCISLGP
CPQGNNESCT DVAKEFQPAV PVKGTMETLP LESQTHPTSP HSLQTHILTK LNFHLRKKVL
EIQWGIPIRA RKSREQTVAA PENISTQKSL ESLNHQGETL LQELPIPPDT LPAPNPEGVH
LKEQLANDLK AVQQNQKQSN SKAVPQGSAH SVSKISQPSG DMTEAHMPCV QVEANVNKPS
LEEPCGPEPQ SPSKSKDPAH VPMLAGNRED PEETKAARDH REGDAGFGRS STREERRPAE
DQRPAGMLPN KTPRGSWRWS RSFHLADPCQ HSPQHHPQLK LPQLPPRVPG EKESEKDLQD
SQTKLTVILE PATIPENAQT VLPQASQGQP FLSQPTQAKP LQGQTLQGQV LHGLVMPVHA
QKKPSLTESS FRNKIKCFLQ HINPKTKGKG HEDSMFSAAA KVAKTRKENV AKSLAPAKSP
VGRSKTEKPT GCSKAQSRPA QKLVGPAFLD GPQSLDDKLR LHSRQPGSAS ALGYPRHCPR
HCPREACANK PGHPT
