F205C_HUMAN
ID F205C_HUMAN Reviewed; 338 AA.
AC A6NFA0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Protein FAM205C {ECO:0000305};
DE AltName: Full=FAM205C pseudogene {ECO:0000312|HGNC:HGNC:42673};
GN Name=FAM205C {ECO:0000312|HGNC:HGNC:42673};
GN Synonyms=FAM205CP {ECO:0000312|HGNC:HGNC:42673};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL355377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS83358.1; -.
DR RefSeq; NP_001296355.1; NM_001309426.1.
DR AlphaFoldDB; A6NFA0; -.
DR SMR; A6NFA0; -.
DR PhosphoSitePlus; A6NFA0; -.
DR BioMuta; FAM205C; -.
DR jPOST; A6NFA0; -.
DR MassIVE; A6NFA0; -.
DR PaxDb; A6NFA0; -.
DR PeptideAtlas; A6NFA0; -.
DR PRIDE; A6NFA0; -.
DR DNASU; 100129969; -.
DR Ensembl; ENST00000603640.6; ENSP00000489585.1; ENSG00000187791.13.
DR GeneID; 100129969; -.
DR KEGG; hsa:100129969; -.
DR CTD; 100129969; -.
DR DisGeNET; 100129969; -.
DR GeneCards; FAM205C; -.
DR HGNC; HGNC:42673; FAM205C.
DR HPA; ENSG00000187791; Tissue enriched (testis).
DR neXtProt; NX_A6NFA0; -.
DR OpenTargets; ENSG00000187791; -.
DR VEuPathDB; HostDB:ENSG00000187791; -.
DR GeneTree; ENSGT00950000183043; -.
DR OMA; FSHWINP; -.
DR OrthoDB; 1485238at2759; -.
DR PhylomeDB; A6NFA0; -.
DR BioGRID-ORCS; 100129969; 0 hits in 7 CRISPR screens.
DR Pharos; A6NFA0; Tdark.
DR PRO; PR:A6NFA0; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; A6NFA0; protein.
DR Bgee; ENSG00000187791; Expressed in sperm and 54 other tissues.
DR ExpressionAtlas; A6NFA0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027970; DUF4599.
DR Pfam; PF15371; DUF4599; 1.
PE 3: Inferred from homology;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..338
FT /note="Protein FAM205C"
FT /id="PRO_0000319052"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 290..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q642A3"
SQ SEQUENCE 338 AA; 37613 MW; A5A5E042A5C39A11 CRC64;
MLSPTFVLWD VGYPLYTYGS ICIIALIIWQ VKKSCQKLSL VPNRSCCRCH RRVQQKSGDR
TSRARRTSQE EAEKLWKLLF LMKSQGWLPQ EGSVRRILCA DPCCQICNVM ALEIKQLLAG
ENNQISLTSL GPSQGSSCLE ALSTSSVSFK HSQDLGSPKS KELSLASVTP TLSQLMDQKS
LTQSAARSAG ADSVQDSWAD HFQRGQRSQV PAVSQVMGSL SSNFEKPGIP LSQQERTKNN
SKFVLENQEA PEVGLDNKMK LFLHWINPEM KDRRHEESIL LSKAETVTQD RTKNIEKSPT
VTKDHVWGAT TQKTTEDPEA QPPSTEEEGL IFCDAPSA
