F205C_MOUSE
ID F205C_MOUSE Reviewed; 371 AA.
AC Q80YD3; Q8C5W8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein FAM205C {ECO:0000305};
GN Name=Fam205c {ECO:0000250|UniProtKB:A6NFA0};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80YD3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80YD3-2; Sequence=VSP_031342;
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DR EMBL; AK077002; BAC36559.1; -; mRNA.
DR EMBL; AL672276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049635; AAH49635.1; -; mRNA.
DR CCDS; CCDS18082.1; -. [Q80YD3-2]
DR CCDS; CCDS89730.1; -. [Q80YD3-1]
DR RefSeq; NP_808453.1; NM_177785.4. [Q80YD3-2]
DR RefSeq; XP_006538035.1; XM_006537972.3.
DR AlphaFoldDB; Q80YD3; -.
DR STRING; 10090.ENSMUSP00000060318; -.
DR iPTMnet; Q80YD3; -.
DR PhosphoSitePlus; Q80YD3; -.
DR PaxDb; Q80YD3; -.
DR PRIDE; Q80YD3; -.
DR ProteomicsDB; 267691; -. [Q80YD3-1]
DR ProteomicsDB; 267692; -. [Q80YD3-2]
DR Ensembl; ENSMUST00000055944; ENSMUSP00000060318; ENSMUSG00000050141. [Q80YD3-2]
DR Ensembl; ENSMUST00000107978; ENSMUSP00000103612; ENSMUSG00000050141. [Q80YD3-1]
DR GeneID; 277773; -.
DR KEGG; mmu:277773; -.
DR UCSC; uc008sog.1; mouse. [Q80YD3-2]
DR UCSC; uc008soh.2; mouse. [Q80YD3-1]
DR CTD; 100129969; -.
DR MGI; MGI:2679716; Fam205c.
DR VEuPathDB; HostDB:ENSMUSG00000050141; -.
DR eggNOG; ENOG502THPB; Eukaryota.
DR GeneTree; ENSGT00950000183043; -.
DR HOGENOM; CLU_061708_0_0_1; -.
DR InParanoid; Q80YD3; -.
DR OMA; FSHWINP; -.
DR OrthoDB; 1223253at2759; -.
DR PhylomeDB; Q80YD3; -.
DR TreeFam; TF337856; -.
DR BioGRID-ORCS; 277773; 0 hits in 40 CRISPR screens.
DR PRO; PR:Q80YD3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80YD3; protein.
DR Bgee; ENSMUSG00000050141; Expressed in spermatid and 40 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027970; DUF4599.
DR Pfam; PF15371; DUF4599; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..371
FT /note="Protein FAM205C"
FT /id="PRO_0000319053"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 189..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 62..86
FT /evidence="ECO:0000255"
FT COMPBIAS 240..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 197
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q642A3"
FT MOD_RES 198
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q642A3"
FT VAR_SEQ 292
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031342"
SQ SEQUENCE 371 AA; 41486 MW; D7F6B0A2B94EA16F CRC64;
MMVPSFILWD VGSSVYTYGS LFIIALIIWH VRRSHRGLRL GPIKSCTKCF RRIKQKPSDR
TLRVKKRTTK EETEKLQKLL SNMKRQGWLP QEGSVRRLLC SDPSCPICNA MALEIQQLLG
VENKKTSSSL LRHSRSFSCL EALSPPKVLN DQSSELSKVL NGQSSELSKV LNGQSSELSK
VLNDQSSELS KVLNDQSSEL SSQHSKDISL PPKFMQSQST DQKLTLSAPL STGNTVLQCY
HPAPQQQPEP QGSNAFQDVS GLSSSSMDEH GVPANQQKKR KKTKKLVSKN QAAPSEAEME
NKMTFFSHWV NPEVKCDRPE ESFAFYKSET GAKPKTGEPK KSSAKVRAEE PNLEKHAKDL
KAKPLHAKRN I
