F210A_MOUSE
ID F210A_MOUSE Reviewed; 273 AA.
AC Q8BGY7; Q3TXD0; Q8BNY5;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein FAM210A;
GN Name=Fam210a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon, Embryo, Retina, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=29618611; DOI=10.1073/pnas.1719089115;
RA Tanaka K.I., Xue Y., Nguyen-Yamamoto L., Morris J.A., Kanazawa I.,
RA Sugimoto T., Wing S.S., Richards J.B., Goltzman D.;
RT "FAM210A is a novel determinant of bone and muscle structure and
RT strength.";
RL Proc. Natl. Acad. Sci. U.S.A. 115:3759-3768(2018).
CC -!- FUNCTION: May play a role in the structure and strength of both muscle
CC and bone. {ECO:0000269|PubMed:29618611}.
CC -!- SUBUNIT: Interacts with ATAD3A. {ECO:0000250|UniProtKB:Q96ND0}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}. Mitochondrion {ECO:0000269|PubMed:29618611}.
CC Cytoplasm {ECO:0000269|PubMed:29618611}.
CC -!- TISSUE SPECIFICITY: Expressed in skeletal muscle, heart, brain but not
CC in bone. {ECO:0000269|PubMed:29618611}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality in homozygotes mice after
CC embryonic day 9.5 (PubMed:29618611). Tamoxifen-inducible Fam210a
CC homozygous knockout mice exhibit decreased grip strength, lean mass of
CC all limbs, bone mineral density, bone biomechanical strength, and
CC elevated osteoclast activity with microarchitectural deterioration of
CC trabecular and cortical bones (PubMed:29618611).
CC {ECO:0000269|PubMed:29618611, ECO:0000303|PubMed:29618611}.
CC -!- SIMILARITY: Belongs to the FAM210 family. {ECO:0000305}.
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DR EMBL; AK034980; BAC28902.1; -; mRNA.
DR EMBL; AK044238; BAC31834.1; -; mRNA.
DR EMBL; AK077093; BAC36609.1; -; mRNA.
DR EMBL; AK049567; BAC33815.1; -; mRNA.
DR EMBL; AK147662; BAE28056.1; -; mRNA.
DR EMBL; AK159319; BAE34986.1; -; mRNA.
DR EMBL; AK162396; BAE36892.1; -; mRNA.
DR EMBL; AK079137; BAC37558.1; -; mRNA.
DR EMBL; BC038695; AAH38695.1; -; mRNA.
DR EMBL; BC095936; AAH95936.1; -; mRNA.
DR CCDS; CCDS29326.1; -.
DR RefSeq; NP_722489.1; NM_153794.4.
DR RefSeq; XP_006525587.1; XM_006525524.3.
DR AlphaFoldDB; Q8BGY7; -.
DR STRING; 10090.ENSMUSP00000045927; -.
DR PhosphoSitePlus; Q8BGY7; -.
DR EPD; Q8BGY7; -.
DR jPOST; Q8BGY7; -.
DR MaxQB; Q8BGY7; -.
DR PaxDb; Q8BGY7; -.
DR PeptideAtlas; Q8BGY7; -.
DR PRIDE; Q8BGY7; -.
DR ProteomicsDB; 275825; -.
DR Antibodypedia; 54115; 18 antibodies from 8 providers.
DR Ensembl; ENSMUST00000042852; ENSMUSP00000045927; ENSMUSG00000038121.
DR GeneID; 108654; -.
DR KEGG; mmu:108654; -.
DR UCSC; uc008fni.1; mouse.
DR CTD; 125228; -.
DR MGI; MGI:1914000; Fam210a.
DR VEuPathDB; HostDB:ENSMUSG00000038121; -.
DR eggNOG; KOG4082; Eukaryota.
DR GeneTree; ENSGT00940000156554; -.
DR HOGENOM; CLU_085747_0_0_1; -.
DR InParanoid; Q8BGY7; -.
DR OMA; MQWNVLR; -.
DR OrthoDB; 1568689at2759; -.
DR PhylomeDB; Q8BGY7; -.
DR TreeFam; TF313283; -.
DR BioGRID-ORCS; 108654; 20 hits in 74 CRISPR screens.
DR ChiTaRS; Fam210a; mouse.
DR PRO; PR:Q8BGY7; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8BGY7; protein.
DR Bgee; ENSMUSG00000038121; Expressed in soleus muscle and 224 other tissues.
DR ExpressionAtlas; Q8BGY7; baseline and differential.
DR Genevisible; Q8BGY7; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR InterPro; IPR045866; FAM210A/B-like.
DR InterPro; IPR009688; FAM210A/B-like_dom.
DR PANTHER; PTHR21377; PTHR21377; 1.
DR Pfam; PF06916; DUF1279; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Membrane; Mitochondrion; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..273
FT /note="Protein FAM210A"
FT /id="PRO_0000274425"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 118..230
FT /note="DUF1279"
FT REGION 94..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 233..269
FT /evidence="ECO:0000255"
FT CONFLICT 64
FT /note="L -> F (in Ref. 1; BAE34986)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 273 AA; 31600 MW; 61F4D63869C5BAC4 CRC64;
MQWNVPRTMS RLALRTFVEA QKARLFDHHW RIKGPLLVHR GEYRVAWTPH LRKQWLHLSA
VQCLAKQRNL LDAQPPQLGT LRQERWEQDI LSKRVLSSSS TSQETPSEKK EETDPLQDKS
ISLYQRFKKT FRQYGKVLIP VHLITSGIWF GTFYYATIKG VNVIPFLEVI GLPDSIVDIL
KNSQSGNALT AYAMFKIATP ARYTVTLGGT SFTVKYLRSH GYMSTPPPVK EYLQGRMEET
KELITEKMEE TKDRLTEKLQ ETKGKVSFKK KVE
