F210B_HUMAN
ID F210B_HUMAN Reviewed; 192 AA.
AC Q96KR6; B2RBQ9; E1P5Y7; Q8WVN2; Q9BYL6; Q9H418;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein FAM210B, mitochondrial {ECO:0000305};
DE Flags: Precursor;
GN Name=FAM210B {ECO:0000312|HGNC:HGNC:16102}; Synonyms=C20orf108;
GN ORFNames=PSEC0265;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kussmann S., Worch S., Hansmann I., Schlote D.;
RT "Mapping and characterization of novel human cDNA based on EST A009R26.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=26968549; DOI=10.1007/s12185-016-1968-4;
RA Kondo A., Fujiwara T., Okitsu Y., Fukuhara N., Onishi Y., Nakamura Y.,
RA Sawada K., Harigae H.;
RT "Identification of a novel putative mitochondrial protein FAM210B
RT associated with erythroid differentiation.";
RL Int. J. Hematol. 103:387-395(2016).
RN [9]
RP FUNCTION, SUBCELLULAR LOCATION, TRANSIT PEPTIDE CLEAVAGE SITE, AND TISSUE
RP SPECIFICITY.
RX PubMed=28594398; DOI=10.1038/cddis.2017.273;
RA Sun S., Liu J., Zhao M., Han Y., Chen P., Mo Q., Wang B., Chen G., Fang Y.,
RA Tian Y., Zhou J., Ma D., Gao Q., Wu P.;
RT "Loss of the novel mitochondrial protein FAM210B promotes metastasis via
RT PDK4-dependent metabolic reprogramming.";
RL Cell Death Dis. 8:E2870-E2870(2017).
CC -!- FUNCTION: Plays a role in erythroid differentiation (PubMed:26968549).
CC Involved in cell proliferation and tumor cell growth suppression
CC (PubMed:28594398). Involved in the metabolic reprogramming of cancer
CC cells in a PDK4-dependent manner (PubMed:28594398).
CC {ECO:0000269|PubMed:26968549, ECO:0000269|PubMed:28594398}.
CC -!- INTERACTION:
CC Q96KR6; Q99437: ATP6V0B; NbExp=3; IntAct=EBI-18938272, EBI-3904417;
CC Q96KR6; P27449: ATP6V0C; NbExp=3; IntAct=EBI-18938272, EBI-721179;
CC Q96KR6; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-18938272, EBI-747430;
CC Q96KR6; O15155: BET1; NbExp=3; IntAct=EBI-18938272, EBI-749204;
CC Q96KR6; Q6UWT4: C5orf46; NbExp=3; IntAct=EBI-18938272, EBI-11986083;
CC Q96KR6; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-18938272, EBI-9083477;
CC Q96KR6; Q08708: CD300C; NbExp=3; IntAct=EBI-18938272, EBI-3915344;
CC Q96KR6; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-18938272, EBI-11959453;
CC Q96KR6; Q8TBE1: CNIH3; NbExp=3; IntAct=EBI-18938272, EBI-12208021;
CC Q96KR6; O43169: CYB5B; NbExp=3; IntAct=EBI-18938272, EBI-1058710;
CC Q96KR6; P00387: CYB5R3; NbExp=3; IntAct=EBI-18938272, EBI-1046040;
CC Q96KR6; P78329: CYP4F2; NbExp=3; IntAct=EBI-18938272, EBI-1752413;
CC Q96KR6; P54852: EMP3; NbExp=3; IntAct=EBI-18938272, EBI-3907816;
CC Q96KR6; Q9Y3D6: FIS1; NbExp=3; IntAct=EBI-18938272, EBI-3385283;
CC Q96KR6; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-18938272, EBI-6166686;
CC Q96KR6; P07686: HEXB; NbExp=3; IntAct=EBI-18938272, EBI-7133736;
CC Q96KR6; P09601: HMOX1; NbExp=3; IntAct=EBI-18938272, EBI-2806151;
CC Q96KR6; P30519: HMOX2; NbExp=3; IntAct=EBI-18938272, EBI-712096;
CC Q96KR6; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-18938272, EBI-725665;
CC Q96KR6; Q01628: IFITM3; NbExp=3; IntAct=EBI-18938272, EBI-7932862;
CC Q96KR6; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-18938272, EBI-12133176;
CC Q96KR6; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-18938272, EBI-12033434;
CC Q96KR6; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-18938272, EBI-11956541;
CC Q96KR6; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-18938272, EBI-12070086;
CC Q96KR6; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-18938272, EBI-10317425;
CC Q96KR6; Q16617: NKG7; NbExp=3; IntAct=EBI-18938272, EBI-3919611;
CC Q96KR6; Q53FV1: ORMDL2; NbExp=3; IntAct=EBI-18938272, EBI-11075081;
CC Q96KR6; Q7RTS5: OTOP3; NbExp=3; IntAct=EBI-18938272, EBI-12853910;
CC Q96KR6; Q04941: PLP2; NbExp=3; IntAct=EBI-18938272, EBI-608347;
CC Q96KR6; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-18938272, EBI-11721828;
CC Q96KR6; Q9NS64: RPRM; NbExp=3; IntAct=EBI-18938272, EBI-1052363;
CC Q96KR6; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-18938272, EBI-10244780;
CC Q96KR6; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-18938272, EBI-10329948;
CC Q96KR6; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-18938272, EBI-749270;
CC Q96KR6; Q7RTY0: SLC16A13; NbExp=3; IntAct=EBI-18938272, EBI-12243266;
CC Q96KR6; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-18938272, EBI-10262251;
CC Q96KR6; Q969S0: SLC35B4; NbExp=3; IntAct=EBI-18938272, EBI-10281213;
CC Q96KR6; Q2M3R5: SLC35G1; NbExp=3; IntAct=EBI-18938272, EBI-13311257;
CC Q96KR6; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-18938272, EBI-8640191;
CC Q96KR6; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-18938272, EBI-12188413;
CC Q96KR6; O43752: STX6; NbExp=3; IntAct=EBI-18938272, EBI-2695795;
CC Q96KR6; O15400: STX7; NbExp=3; IntAct=EBI-18938272, EBI-3221827;
CC Q96KR6; P57105: SYNJ2BP; NbExp=3; IntAct=EBI-18938272, EBI-1049004;
CC Q96KR6; P02787: TF; NbExp=3; IntAct=EBI-18938272, EBI-714319;
CC Q96KR6; P02786: TFRC; NbExp=3; IntAct=EBI-18938272, EBI-355727;
CC Q96KR6; O14925: TIMM23; NbExp=3; IntAct=EBI-18938272, EBI-1047996;
CC Q96KR6; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-18938272, EBI-6268651;
CC Q96KR6; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-18938272, EBI-12845616;
CC Q96KR6; P17152: TMEM11; NbExp=3; IntAct=EBI-18938272, EBI-723946;
CC Q96KR6; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-18938272, EBI-2844246;
CC Q96KR6; Q14656: TMEM187; NbExp=3; IntAct=EBI-18938272, EBI-13046724;
CC Q96KR6; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-18938272, EBI-741829;
CC Q96KR6; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-18938272, EBI-988826;
CC Q96KR6; P23763-3: VAMP1; NbExp=3; IntAct=EBI-18938272, EBI-12097582;
CC Q96KR6; Q15836: VAMP3; NbExp=3; IntAct=EBI-18938272, EBI-722343;
CC Q96KR6; O75379: VAMP4; NbExp=3; IntAct=EBI-18938272, EBI-744953;
CC Q96KR6; Q9BQB6: VKORC1; NbExp=3; IntAct=EBI-18938272, EBI-6256462;
CC Q96KR6; O95070: YIF1A; NbExp=3; IntAct=EBI-18938272, EBI-2799703;
CC Q96KR6; Q8IVQ6: ZDHHC21; NbExp=3; IntAct=EBI-18938272, EBI-2849773;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26968549}.
CC Mitochondrion outer membrane {ECO:0000269|PubMed:28594398}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in late erythroblast differentiation
CC stages (PubMed:26968549). Underexpressed in ovarian cancer epithelia
CC cells compared with normal human ovarian surface epithelia
CC (PubMed:28594398). {ECO:0000269|PubMed:26968549,
CC ECO:0000269|PubMed:28594398}.
CC -!- INDUCTION: Up-regulated by the erythroid transcription factor GATA1
CC (PubMed:26968549). {ECO:0000269|PubMed:26968549}.
CC -!- SIMILARITY: Belongs to the FAM210 family. {ECO:0000305}.
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DR EMBL; AJ311123; CAC67490.1; -; mRNA.
DR EMBL; AK075565; BAC11704.1; -; mRNA.
DR EMBL; AK314768; BAG37306.1; -; mRNA.
DR EMBL; AL121914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75564.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW75565.1; -; Genomic_DNA.
DR EMBL; BC017725; AAH17725.1; -; mRNA.
DR CCDS; CCDS13450.1; -.
DR RefSeq; NP_543011.2; NM_080821.2.
DR AlphaFoldDB; Q96KR6; -.
DR BioGRID; 125482; 92.
DR IntAct; Q96KR6; 69.
DR MINT; Q96KR6; -.
DR STRING; 9606.ENSP00000360437; -.
DR iPTMnet; Q96KR6; -.
DR PhosphoSitePlus; Q96KR6; -.
DR BioMuta; FAM210B; -.
DR DMDM; 41688811; -.
DR EPD; Q96KR6; -.
DR jPOST; Q96KR6; -.
DR MassIVE; Q96KR6; -.
DR MaxQB; Q96KR6; -.
DR PaxDb; Q96KR6; -.
DR PeptideAtlas; Q96KR6; -.
DR PRIDE; Q96KR6; -.
DR ProteomicsDB; 77108; -.
DR TopDownProteomics; Q96KR6; -.
DR Antibodypedia; 63338; 27 antibodies from 10 providers.
DR DNASU; 116151; -.
DR Ensembl; ENST00000371384.4; ENSP00000360437.3; ENSG00000124098.10.
DR GeneID; 116151; -.
DR KEGG; hsa:116151; -.
DR MANE-Select; ENST00000371384.4; ENSP00000360437.3; NM_080821.3; NP_543011.2.
DR UCSC; uc002xxc.4; human.
DR CTD; 116151; -.
DR DisGeNET; 116151; -.
DR GeneCards; FAM210B; -.
DR HGNC; HGNC:16102; FAM210B.
DR HPA; ENSG00000124098; Low tissue specificity.
DR MIM; 618722; gene.
DR neXtProt; NX_Q96KR6; -.
DR OpenTargets; ENSG00000124098; -.
DR PharmGKB; PA25647; -.
DR VEuPathDB; HostDB:ENSG00000124098; -.
DR eggNOG; KOG4526; Eukaryota.
DR GeneTree; ENSGT00940000156134; -.
DR HOGENOM; CLU_1414738_0_0_1; -.
DR InParanoid; Q96KR6; -.
DR OMA; DCRGRQD; -.
DR OrthoDB; 1506373at2759; -.
DR PhylomeDB; Q96KR6; -.
DR TreeFam; TF313283; -.
DR PathwayCommons; Q96KR6; -.
DR SignaLink; Q96KR6; -.
DR BioGRID-ORCS; 116151; 6 hits in 1040 CRISPR screens.
DR ChiTaRS; FAM210B; human.
DR GenomeRNAi; 116151; -.
DR Pharos; Q96KR6; Tbio.
DR PRO; PR:Q96KR6; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q96KR6; protein.
DR Bgee; ENSG00000124098; Expressed in parotid gland and 185 other tissues.
DR ExpressionAtlas; Q96KR6; baseline and differential.
DR Genevisible; Q96KR6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031224; C:intrinsic component of membrane; IDA:UniProtKB.
DR GO; GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IDA:UniProtKB.
DR GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
DR GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IMP:UniProtKB.
DR InterPro; IPR045866; FAM210A/B-like.
DR InterPro; IPR009688; FAM210A/B-like_dom.
DR PANTHER; PTHR21377; PTHR21377; 1.
DR Pfam; PF06916; DUF1279; 1.
PE 1: Evidence at protein level;
KW Differentiation; Erythrocyte maturation; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix; Tumor suppressor.
FT TRANSIT 1..58
FT /note="Mitochondrion"
FT /evidence="ECO:0000255, ECO:0000269|PubMed:28594398"
FT CHAIN 59..192
FT /note="Protein FAM210B, mitochondrial"
FT /id="PRO_0000079451"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 80..191
FT /note="DUF1279"
FT REGION 57..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 126
FT /note="P -> S (in dbSNP:rs6099115)"
FT /id="VAR_033763"
FT CONFLICT 36
FT /note="P -> L (in Ref. 1; CAC67490)"
FT /evidence="ECO:0000305"
FT CONFLICT 161
FT /note="A -> V (in Ref. 6; AAH17725)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 192 AA; 20424 MW; FE895D3E5FB042D2 CRC64;
MAGLLALLGP AGRVGARVRP RATWLLGATA PCAPPPLALA LLPPRLDARL LRTARGDCRG
HQDPSQATGT TGSSVSCTEE KKQSKSQQLK KIFQEYGTVG VSLHIGISLI SLGIFYMVVS
SGVDMPAILL KLGFKESLVQ SKMAAGTSTF VVAYAIHKLF APVRISITLV SVPLIVRYFR
KVGFFKPPAA KP
