F210B_MOUSE
ID F210B_MOUSE Reviewed; 190 AA.
AC Q9D8B6; Q3UFZ3; Q91WA2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein FAM210B, mitochondrial {ECO:0000305};
DE Flags: Precursor;
GN Name=Fam210b {ECO:0000312|MGI:MGI:1914267};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=26968549; DOI=10.1007/s12185-016-1968-4;
RA Kondo A., Fujiwara T., Okitsu Y., Fukuhara N., Onishi Y., Nakamura Y.,
RA Sawada K., Harigae H.;
RT "Identification of a novel putative mitochondrial protein FAM210B
RT associated with erythroid differentiation.";
RL Int. J. Hematol. 103:387-395(2016).
CC -!- FUNCTION: Plays a role in erythroid differentiation. Involved in cell
CC proliferation and tumor cell growth suppression. Involved in the
CC metabolic reprogramming of cancer cells in a PDK4-dependent manner.
CC {ECO:0000250|UniProtKB:Q96KR6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q96KR6}.
CC Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96KR6}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in late erythroblast differentiation
CC stages (PubMed:26968549). {ECO:0000269|PubMed:26968549}.
CC -!- INDUCTION: Up-regulated by the erythroid transcription factor GATA1
CC (PubMed:26968549). {ECO:0000269|PubMed:26968549}.
CC -!- SIMILARITY: Belongs to the FAM210 family. {ECO:0000305}.
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DR EMBL; AK008190; BAB25521.1; -; mRNA.
DR EMBL; AK076087; BAC36173.1; -; mRNA.
DR EMBL; AK147935; BAE28240.1; -; mRNA.
DR EMBL; AK148213; BAE28416.1; -; mRNA.
DR EMBL; AK149497; BAE28920.1; -; mRNA.
DR EMBL; AK160529; BAE35847.1; -; mRNA.
DR EMBL; AL844162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016210; AAH16210.1; -; mRNA.
DR EMBL; BC057642; AAH57642.1; -; mRNA.
DR CCDS; CCDS17128.1; -.
DR RefSeq; NP_080188.3; NM_025912.4.
DR RefSeq; XP_006500122.1; XM_006500059.1.
DR AlphaFoldDB; Q9D8B6; -.
DR STRING; 10090.ENSMUSP00000028995; -.
DR iPTMnet; Q9D8B6; -.
DR PhosphoSitePlus; Q9D8B6; -.
DR MaxQB; Q9D8B6; -.
DR PaxDb; Q9D8B6; -.
DR PRIDE; Q9D8B6; -.
DR ProteomicsDB; 275728; -.
DR Antibodypedia; 63338; 27 antibodies from 10 providers.
DR DNASU; 67017; -.
DR Ensembl; ENSMUST00000028995; ENSMUSP00000028995; ENSMUSG00000027495.
DR GeneID; 67017; -.
DR KEGG; mmu:67017; -.
DR UCSC; uc012ckn.1; mouse.
DR CTD; 116151; -.
DR MGI; MGI:1914267; Fam210b.
DR VEuPathDB; HostDB:ENSMUSG00000027495; -.
DR eggNOG; KOG4526; Eukaryota.
DR GeneTree; ENSGT00940000156134; -.
DR HOGENOM; CLU_1414738_0_0_1; -.
DR InParanoid; Q9D8B6; -.
DR OMA; DCRGRQD; -.
DR OrthoDB; 1506373at2759; -.
DR PhylomeDB; Q9D8B6; -.
DR TreeFam; TF313283; -.
DR BioGRID-ORCS; 67017; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Fam210b; mouse.
DR PRO; PR:Q9D8B6; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D8B6; protein.
DR Bgee; ENSMUSG00000027495; Expressed in fetal liver hematopoietic progenitor cell and 253 other tissues.
DR Genevisible; Q9D8B6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031224; C:intrinsic component of membrane; ISS:UniProtKB.
DR GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
DR GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
DR GO; GO:0045648; P:positive regulation of erythrocyte differentiation; ISS:UniProtKB.
DR InterPro; IPR045866; FAM210A/B-like.
DR InterPro; IPR009688; FAM210A/B-like_dom.
DR PANTHER; PTHR21377; PTHR21377; 1.
DR Pfam; PF06916; DUF1279; 1.
PE 1: Evidence at protein level;
KW Differentiation; Erythrocyte maturation; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix; Tumor suppressor.
FT TRANSIT 1..58
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:Q96KR6, ECO:0000255"
FT CHAIN 59..190
FT /note="Protein FAM210B, mitochondrial"
FT /id="PRO_0000079452"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 78..189
FT /note="DUF1279"
FT REGION 56..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 73
FT /note="S -> G (in Ref. 3; AAH16210/AAH57642)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 190 AA; 20344 MW; 91C6FEA2832DDF9B CRC64;
MAGLLTLLGP AGRVSTRLRP LAPWLLGTAT SCAPPLWALA LSHPVPDARL LRTARGDCLS
RQEPNRTPEP GGSVTGTEKK LSRTQQLKKV FQEYGAVGVS MHIGISLVSL GIFYTVVSSG
IDMSAILLKL GFKESLVQSK MAAGTSTFVV AYAIHKLFAP VRISITLVSV PFVVRYFRSV
GLFKPPATKP
