F214A_MOUSE
ID F214A_MOUSE Reviewed; 1075 AA.
AC Q69ZK7; E9PX00; Q8K0I6; Q8K266;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Protein FAM214A;
GN Name=Fam214a; Synonyms=Kiaa1370;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Mammary gland, and Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q69ZK7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q69ZK7-2; Sequence=VSP_030582;
CC -!- SIMILARITY: Belongs to the FAM214 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH32966.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD32439.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK173161; BAD32439.1; ALT_INIT; Transcribed_RNA.
DR EMBL; CT025657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT033761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031353; AAH31353.1; -; mRNA.
DR EMBL; BC032966; AAH32966.1; ALT_INIT; mRNA.
DR CCDS; CCDS52857.1; -. [Q69ZK7-1]
DR CCDS; CCDS52858.1; -. [Q69ZK7-2]
DR RefSeq; NP_001106754.1; NM_001113283.1. [Q69ZK7-1]
DR RefSeq; NP_705812.2; NM_153584.2. [Q69ZK7-2]
DR RefSeq; XP_006511189.1; XM_006511126.3. [Q69ZK7-1]
DR RefSeq; XP_006511190.1; XM_006511127.3.
DR AlphaFoldDB; Q69ZK7; -.
DR STRING; 10090.ENSMUSP00000080442; -.
DR iPTMnet; Q69ZK7; -.
DR PhosphoSitePlus; Q69ZK7; -.
DR EPD; Q69ZK7; -.
DR jPOST; Q69ZK7; -.
DR PaxDb; Q69ZK7; -.
DR PeptideAtlas; Q69ZK7; -.
DR PRIDE; Q69ZK7; -.
DR ProteomicsDB; 275826; -. [Q69ZK7-1]
DR ProteomicsDB; 275827; -. [Q69ZK7-2]
DR Antibodypedia; 51855; 21 antibodies from 7 providers.
DR Ensembl; ENSMUST00000081746; ENSMUSP00000080442; ENSMUSG00000034858. [Q69ZK7-2]
DR Ensembl; ENSMUST00000170846; ENSMUSP00000129319; ENSMUSG00000034858. [Q69ZK7-1]
DR Ensembl; ENSMUST00000215370; ENSMUSP00000149021; ENSMUSG00000034858. [Q69ZK7-1]
DR GeneID; 235493; -.
DR KEGG; mmu:235493; -.
DR UCSC; uc009qrl.2; mouse. [Q69ZK7-2]
DR UCSC; uc012gww.1; mouse. [Q69ZK7-1]
DR CTD; 56204; -.
DR MGI; MGI:2387648; Fam214a.
DR VEuPathDB; HostDB:ENSMUSG00000034858; -.
DR eggNOG; KOG2306; Eukaryota.
DR GeneTree; ENSGT00940000157573; -.
DR HOGENOM; CLU_011957_0_0_1; -.
DR InParanoid; Q69ZK7; -.
DR OMA; VPHPYSK; -.
DR OrthoDB; 383904at2759; -.
DR TreeFam; TF325496; -.
DR BioGRID-ORCS; 235493; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Fam214a; mouse.
DR PRO; PR:Q69ZK7; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q69ZK7; protein.
DR Bgee; ENSMUSG00000034858; Expressed in otolith organ and 248 other tissues.
DR ExpressionAtlas; Q69ZK7; baseline and differential.
DR Genevisible; Q69ZK7; MM.
DR InterPro; IPR025261; DUF4210.
DR InterPro; IPR033473; FAM214/SPAC3H8.04_C.
DR Pfam; PF13889; Chromosome_seg; 1.
DR Pfam; PF13915; DUF4210; 1.
DR SMART; SM01177; DUF4210; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..1075
FT /note="Protein FAM214A"
FT /id="PRO_0000315614"
FT REGION 430..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..5
FT /note="MKPDR -> MVFSGNKGLRRQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030582"
FT CONFLICT 100
FT /note="Y -> F (in Ref. 3; AAH31353)"
FT /evidence="ECO:0000305"
FT CONFLICT 617
FT /note="K -> N (in Ref. 1; BAD32439)"
FT /evidence="ECO:0000305"
FT CONFLICT 658
FT /note="Q -> H (in Ref. 1; BAD32439)"
FT /evidence="ECO:0000305"
FT CONFLICT 710
FT /note="C -> Y (in Ref. 3; AAH32966)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1075 AA; 119272 MW; 273531DB7746D718 CRC64;
MKPDRDALDE YFEYDAEEFL VSLALLITEG RTPECSVKGR AESFHCPPAQ SRFPGTARHE
CSDKLAQCRQ ARRTRSEVTL LWKNNLPIMV EVMLLPDCCY SDEGPSTEGA DLNDPAIKQD
ALLLERWILE PVPRQNGDRF IEEKALLLAV RSFVFFSQLS AWLSVSHGAI PRNILYRISA
ADVDLQWSFS QTPTEHVFPV PNVSHNVALK VSVQSLPRQA HYPVLTCSIH TNIGLYEKRI
QEQELRACQH HGPGEVEYRC PSSSQSLCSK HTWTMAPVSA LHVRSGMPPE YTAAIRNVRL
CPGTGSKSDQ GAPQASVLGF SGTGGEVRSQ EASVRTFKSL PVVDSSVSSC QSSRQPVGEP
NPLMDSLIQD RQEVIARIAQ HLIHCDPSSS RMSELPFNTQ ESTSLSPKLH PVSQESGCVR
RYKEAFSVSF GSPEFGSPGD SREGKVREKS ETRPGETCTS HSLYPRQPAG EANPLIGSLL
QERQDVIARI AQHLEHIDPA AHIPRPAFSK HDSNSIPSKV FRSSFDDKTL LKKGRENVSV
SVSHTEVSLL GDRGDGESLK PSKCLRSFKY SPQEKPLKPE VRTQHQNHPD SITPTARQEL
LNKAAGLLTS SNTALCKESS LGLVSRLEST SCKLQLKEQE MSHETEKQCL HCNSIDKQIC
TNTCTEKIND EHSPGSLRHL QCDDSKGIDS KLKVTLLEMP DSLNKNKTNC SSKDSKRSKT
CEQSIRVGTE NDLSEENEGP GSTVSDRLKT EQEAKRDSGA GKPHSVKHCL SAGERLHSAD
MLRTTLKHSS VWRKHNFHSL DGTSTRAFHP QTGLPLLSSP VPQRKTQSGC FDLDASLLHL
RSLSSKSSRP CLNIDEDPDV HEKPFLSSSA PPITSLSLLG NFEESVLNYR LDPLGIVDGF
TAEVGASGTF CPTHLTLPVE VSFYSVSDDN APSPYMGVIT LESLGKRGYR VPPSGTIQVT
LFNPNKTVVK MFVVVYDLRG MPANHQTFLR QRTFSVPVKQ EMKRSINKEN VQHTAQLLRY
LIHLRFQSSK SGKIYLHRDV RLLFSRKSME VDSGAAYELK SYTESPTNPQ FSPRC
