F214B_MOUSE
ID F214B_MOUSE Reviewed; 538 AA.
AC Q8BR27; B0QZW6; Q3TTG5; Q3U3I3; Q3UEC3; Q69ZG9; Q6IR39;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Protein FAM214B;
GN Name=Fam214b; Synonyms=Kiaa1539;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Bone marrow, Corpora quadrigemina, Dendritic cell, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 308-538.
RC TISSUE=Pancreatic islet;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254 AND SER-255, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the FAM214 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAQ12875.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK045811; BAC32500.1; -; mRNA.
DR EMBL; AK149610; BAE28988.1; -; mRNA.
DR EMBL; AK154748; BAE32803.1; -; mRNA.
DR EMBL; AK161380; BAE36360.1; -; mRNA.
DR EMBL; AL672276; CAM14325.1; -; Genomic_DNA.
DR EMBL; AL672276; CAQ12875.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC046771; AAH46771.1; -; mRNA.
DR EMBL; BC071191; AAH71191.1; -; mRNA.
DR EMBL; AK173197; BAD32475.1; -; mRNA.
DR CCDS; CCDS18090.1; -.
DR RefSeq; NP_001240282.1; NM_001253353.1.
DR RefSeq; NP_001240283.1; NM_001253354.1.
DR RefSeq; NP_766279.1; NM_172691.3.
DR RefSeq; XP_006537885.1; XM_006537822.2.
DR RefSeq; XP_006537886.1; XM_006537823.3.
DR RefSeq; XP_006537887.1; XM_006537824.1.
DR RefSeq; XP_011248296.1; XM_011249994.1.
DR RefSeq; XP_017175614.1; XM_017320125.1.
DR AlphaFoldDB; Q8BR27; -.
DR BioGRID; 230930; 2.
DR STRING; 10090.ENSMUSP00000103592; -.
DR iPTMnet; Q8BR27; -.
DR PhosphoSitePlus; Q8BR27; -.
DR PaxDb; Q8BR27; -.
DR PRIDE; Q8BR27; -.
DR ProteomicsDB; 275828; -.
DR Antibodypedia; 56170; 23 antibodies from 9 providers.
DR Ensembl; ENSMUST00000036462; ENSMUSP00000038177; ENSMUSG00000036002.
DR Ensembl; ENSMUST00000107956; ENSMUSP00000103590; ENSMUSG00000036002.
DR Ensembl; ENSMUST00000107957; ENSMUSP00000103591; ENSMUSG00000036002.
DR Ensembl; ENSMUST00000107958; ENSMUSP00000103592; ENSMUSG00000036002.
DR Ensembl; ENSMUST00000107959; ENSMUSP00000103593; ENSMUSG00000036002.
DR GeneID; 230088; -.
DR KEGG; mmu:230088; -.
DR UCSC; uc008soz.2; mouse.
DR CTD; 80256; -.
DR MGI; MGI:2441854; Fam214b.
DR VEuPathDB; HostDB:ENSMUSG00000036002; -.
DR eggNOG; KOG2306; Eukaryota.
DR GeneTree; ENSGT00940000159834; -.
DR HOGENOM; CLU_031463_0_0_1; -.
DR InParanoid; Q8BR27; -.
DR OMA; FEDEGPA; -.
DR OrthoDB; 383904at2759; -.
DR PhylomeDB; Q8BR27; -.
DR TreeFam; TF325496; -.
DR BioGRID-ORCS; 230088; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Fam214b; mouse.
DR PRO; PR:Q8BR27; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BR27; protein.
DR Bgee; ENSMUSG00000036002; Expressed in ascending aorta and 219 other tissues.
DR ExpressionAtlas; Q8BR27; baseline and differential.
DR Genevisible; Q8BR27; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR InterPro; IPR025261; DUF4210.
DR InterPro; IPR033473; FAM214/SPAC3H8.04_C.
DR Pfam; PF13889; Chromosome_seg; 1.
DR Pfam; PF13915; DUF4210; 1.
DR SMART; SM01177; DUF4210; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..538
FT /note="Protein FAM214B"
FT /id="PRO_0000313622"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..241
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 254
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 255
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 57
FT /note="A -> T (in Ref. 1; BAE36360)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="Missing (in Ref. 2; CAQ12875)"
FT /evidence="ECO:0000305"
FT CONFLICT 261
FT /note="A -> P (in Ref. 3; AAH71191)"
FT /evidence="ECO:0000305"
FT CONFLICT 325
FT /note="R -> G (in Ref. 1; BAE28988)"
FT /evidence="ECO:0000305"
FT CONFLICT 515
FT /note="D -> G (in Ref. 1; BAE32803)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 538 AA; 57075 MW; C5D99B108487A580 CRC64;
MRHVQAELSP SSEPEAGPSQ PPVRQGTLQG GLLMGYSPAG GATSPGVYQV SIFSPSAGAS
EPPRALKRPA PPTEGPRELK RGPGLGAREG LPPEEPSTVG LLSPEGLGLG LGVASQHFSH
HGLCVVEHGG NTTSPWTSGT QSTPWLSSNA SFNTLHTRDW AFPDQGGQGC LGETPGPAPS
GQLHTLDTDL HNLAQIGGKS PVARVGNGSN PWPRESHGTA NGHSPEHTPP GPGPPGPCPT
KRRLLPAGET LDVSSEDEGP APRRRRGTLG CPLAANSSDA KATPFWSHLL PGPKEPVLDP
TDCSPMGRRL KGARRLKLSS LRTLRKGPGL LSPPSASPFP TPAVSRTLLG NFEESLLRGR
FAPSGHIEGF TAEIGASGSY CPQHVTLPVT VTFFDVSEQN APAPFLGVVD LTPLGRKGYS
VPKVGTIQVT LFNPNQTVVK MFLVTFDFSD MPAAHMTFLR HRLFLVPVGE EGNASPTHRL
LCYLLHLRFR SSRSGRLSLH GDIRLLFSRR SLELDTGLPY ELQAVTEAPH NPRYSPLP
