ID   F216A_HUMAN             Reviewed;         273 AA.
AC   Q8WUB2; A6NH30; Q99776;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Protein FAM216A;
GN   Name=FAM216A; Synonyms=C12orf24;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=9110174; DOI=10.1101/gr.7.4.353;
RA   Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W.,
RA   Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.;
RT   "Large-scale concatenation cDNA sequencing.";
RL   Genome Res. 7:353-358(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the FAM216 family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-18 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; U79274; AAB50215.1; -; mRNA.
DR   EMBL; CR457001; CAG33282.1; -; mRNA.
DR   EMBL; AC002350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471054; EAW97917.1; -; Genomic_DNA.
DR   EMBL; BC020967; AAH20967.1; -; mRNA.
DR   CCDS; CCDS31899.1; -.
DR   RefSeq; NP_037432.2; NM_013300.2.
DR   AlphaFoldDB; Q8WUB2; -.
DR   BioGRID; 118951; 8.
DR   IntAct; Q8WUB2; 2.
DR   MINT; Q8WUB2; -.
DR   STRING; 9606.ENSP00000366901; -.
DR   iPTMnet; Q8WUB2; -.
DR   PhosphoSitePlus; Q8WUB2; -.
DR   BioMuta; FAM216A; -.
DR   DMDM; 74730685; -.
DR   MassIVE; Q8WUB2; -.
DR   MaxQB; Q8WUB2; -.
DR   PaxDb; Q8WUB2; -.
DR   PeptideAtlas; Q8WUB2; -.
DR   PRIDE; Q8WUB2; -.
DR   ProteomicsDB; 74653; -.
DR   Antibodypedia; 31011; 107 antibodies from 19 providers.
DR   DNASU; 29902; -.
DR   Ensembl; ENST00000377673.10; ENSP00000366901.5; ENSG00000204856.12.
DR   GeneID; 29902; -.
DR   KEGG; hsa:29902; -.
DR   MANE-Select; ENST00000377673.10; ENSP00000366901.5; NM_013300.3; NP_037432.2.
DR   UCSC; uc001tqu.5; human.
DR   CTD; 29902; -.
DR   GeneCards; FAM216A; -.
DR   HGNC; HGNC:30180; FAM216A.
DR   HPA; ENSG00000204856; Group enriched (brain, testis).
DR   neXtProt; NX_Q8WUB2; -.
DR   OpenTargets; ENSG00000204856; -.
DR   PharmGKB; PA128395781; -.
DR   VEuPathDB; HostDB:ENSG00000204856; -.
DR   eggNOG; ENOG502SC0D; Eukaryota.
DR   GeneTree; ENSGT00940000154512; -.
DR   HOGENOM; CLU_096833_0_0_1; -.
DR   InParanoid; Q8WUB2; -.
DR   OMA; KPGRLFM; -.
DR   OrthoDB; 1092818at2759; -.
DR   PhylomeDB; Q8WUB2; -.
DR   TreeFam; TF337546; -.
DR   PathwayCommons; Q8WUB2; -.
DR   SignaLink; Q8WUB2; -.
DR   BioGRID-ORCS; 29902; 9 hits in 1078 CRISPR screens.
DR   GenomeRNAi; 29902; -.
DR   Pharos; Q8WUB2; Tdark.
DR   PRO; PR:Q8WUB2; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8WUB2; protein.
DR   Bgee; ENSG00000204856; Expressed in left testis and 166 other tissues.
DR   ExpressionAtlas; Q8WUB2; baseline and differential.
DR   Genevisible; Q8WUB2; HS.
DR   InterPro; IPR029373; FAM216.
DR   PANTHER; PTHR16476; PTHR16476; 1.
DR   Pfam; PF15107; FAM216B; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..273
FT                   /note="Protein FAM216A"
FT                   /id="PRO_0000288861"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         225
FT                   /note="R -> G (in dbSNP:rs17188964)"
FT                   /id="VAR_032513"
FT   CONFLICT        200
FT                   /note="R -> W (in Ref. 1; AAB50215)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   273 AA;  30792 MW;  B06EF30057AB8586 CRC64;
     MLGQLLPHTA RGLGAAEMPG QGPGSDWTER SSSAEPPAVA GTEGGGGGSA GYSCYQNSKG
     SDRIKDGYKV NSHIAKLQEL WKTPQNQTIH LSKSMMEASF FKHPDLTTGQ KRYLCSIAKI
     YNANYLKMLM KRQYMHVLQH SSQKPGVLTH HRSRLSSRYS QKQHYPCTTW RHQLEREDSG
     SSDIAAASAP EMLIQHSLWR PVRNKEGIKT GYASKTRCKS LKIFRRPRKL FMQTVSSDDS
     ESHMSEEKKE EDLLNNFMQS MSIEEQGEHL MLT