F216B_HUMAN
ID F216B_HUMAN Reviewed; 139 AA.
AC Q8N7L0; B1ALI3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein FAM216B;
GN Name=FAM216B; Synonyms=C13orf30;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the FAM216 family. {ECO:0000305}.
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DR EMBL; AK098238; BAC05268.1; -; mRNA.
DR EMBL; AL138819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08682.1; -; Genomic_DNA.
DR EMBL; BC093659; AAH93659.1; -; mRNA.
DR EMBL; BC112237; AAI12238.1; -; mRNA.
DR CCDS; CCDS9386.1; -.
DR RefSeq; NP_001305861.1; NM_001318932.1.
DR RefSeq; NP_872314.1; NM_182508.2.
DR AlphaFoldDB; Q8N7L0; -.
DR BioGRID; 126878; 1.
DR STRING; 9606.ENSP00000445786; -.
DR BioMuta; FAM216B; -.
DR DMDM; 74729231; -.
DR MassIVE; Q8N7L0; -.
DR PaxDb; Q8N7L0; -.
DR PeptideAtlas; Q8N7L0; -.
DR PRIDE; Q8N7L0; -.
DR ProteomicsDB; 72305; -.
DR Antibodypedia; 42211; 49 antibodies from 18 providers.
DR DNASU; 144809; -.
DR Ensembl; ENST00000313851.3; ENSP00000319336.1; ENSG00000179813.7.
DR Ensembl; ENST00000537894.5; ENSP00000445786.1; ENSG00000179813.7.
DR GeneID; 144809; -.
DR KEGG; hsa:144809; -.
DR MANE-Select; ENST00000313851.3; ENSP00000319336.1; NM_001318932.2; NP_001305861.1.
DR UCSC; uc010tfk.3; human.
DR CTD; 144809; -.
DR GeneCards; FAM216B; -.
DR HGNC; HGNC:26883; FAM216B.
DR HPA; ENSG00000179813; Tissue enriched (fallopian).
DR neXtProt; NX_Q8N7L0; -.
DR OpenTargets; ENSG00000179813; -.
DR PharmGKB; PA147358510; -.
DR VEuPathDB; HostDB:ENSG00000179813; -.
DR eggNOG; ENOG502SAWN; Eukaryota.
DR GeneTree; ENSGT00940000154512; -.
DR HOGENOM; CLU_125533_0_0_1; -.
DR InParanoid; Q8N7L0; -.
DR OMA; RVPHSIY; -.
DR OrthoDB; 1521353at2759; -.
DR PhylomeDB; Q8N7L0; -.
DR TreeFam; TF337013; -.
DR PathwayCommons; Q8N7L0; -.
DR BioGRID-ORCS; 144809; 14 hits in 1061 CRISPR screens.
DR GenomeRNAi; 144809; -.
DR Pharos; Q8N7L0; Tdark.
DR PRO; PR:Q8N7L0; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q8N7L0; protein.
DR Bgee; ENSG00000179813; Expressed in bronchial epithelial cell and 64 other tissues.
DR Genevisible; Q8N7L0; HS.
DR InterPro; IPR029373; FAM216.
DR PANTHER; PTHR16476; PTHR16476; 1.
DR Pfam; PF15107; FAM216B; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..139
FT /note="Protein FAM216B"
FT /id="PRO_0000263728"
FT VARIANT 134
FT /note="R -> C (in dbSNP:rs35889214)"
FT /id="VAR_033743"
SQ SEQUENCE 139 AA; 16362 MW; 1D4FBB5144446FAD CRC64;
MGQNWKRQQK LWNVPQLPFI RVPPSIYDTS LLKALNQGQQ RYFYSIMRIY NSRPQWEALQ
TRYIHSLQHQ QLLGYITQRE ALSYALVLRD STKRASAKVA PQRTIPRKTS AMTRRCPSVL
PVSVVLPRAQ SKRRQVLRN
