ID   F217A_HUMAN             Reviewed;         508 AA.
AC   Q8IXS0; Q5JYK1;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 2.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Protein FAM217A;
GN   Name=FAM217A; Synonyms=C6orf146;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-431.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8IXS0; Q8IYF3-3: TEX11; NbExp=3; IntAct=EBI-10694567, EBI-11523345;
CC   -!- SIMILARITY: Belongs to the FAM217 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL033383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC039349; AAH39349.1; -; mRNA.
DR   CCDS; CCDS4489.1; -.
DR   RefSeq; NP_775834.2; NM_173563.2.
DR   AlphaFoldDB; Q8IXS0; -.
DR   BioGRID; 128817; 3.
DR   IntAct; Q8IXS0; 2.
DR   STRING; 9606.ENSP00000274673; -.
DR   GlyGen; Q8IXS0; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8IXS0; -.
DR   PhosphoSitePlus; Q8IXS0; -.
DR   BioMuta; FAM217A; -.
DR   MaxQB; Q8IXS0; -.
DR   PaxDb; Q8IXS0; -.
DR   PeptideAtlas; Q8IXS0; -.
DR   PRIDE; Q8IXS0; -.
DR   ProteomicsDB; 71054; -.
DR   Antibodypedia; 44131; 64 antibodies from 15 providers.
DR   DNASU; 222826; -.
DR   Ensembl; ENST00000274673.8; ENSP00000274673.3; ENSG00000145975.15.
DR   GeneID; 222826; -.
DR   KEGG; hsa:222826; -.
DR   MANE-Select; ENST00000274673.8; ENSP00000274673.3; NM_173563.3; NP_775834.2.
DR   UCSC; uc003mvx.4; human.
DR   CTD; 222826; -.
DR   GeneCards; FAM217A; -.
DR   HGNC; HGNC:21362; FAM217A.
DR   HPA; ENSG00000145975; Tissue enriched (testis).
DR   neXtProt; NX_Q8IXS0; -.
DR   OpenTargets; ENSG00000145975; -.
DR   PharmGKB; PA134935759; -.
DR   VEuPathDB; HostDB:ENSG00000145975; -.
DR   eggNOG; ENOG502SAD6; Eukaryota.
DR   GeneTree; ENSGT00940000154543; -.
DR   HOGENOM; CLU_026138_0_0_1; -.
DR   InParanoid; Q8IXS0; -.
DR   OrthoDB; 529883at2759; -.
DR   PhylomeDB; Q8IXS0; -.
DR   TreeFam; TF337855; -.
DR   PathwayCommons; Q8IXS0; -.
DR   SignaLink; Q8IXS0; -.
DR   BioGRID-ORCS; 222826; 15 hits in 1069 CRISPR screens.
DR   ChiTaRS; FAM217A; human.
DR   GenomeRNAi; 222826; -.
DR   Pharos; Q8IXS0; Tdark.
DR   PRO; PR:Q8IXS0; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q8IXS0; protein.
DR   Bgee; ENSG00000145975; Expressed in sperm and 103 other tissues.
DR   ExpressionAtlas; Q8IXS0; baseline and differential.
DR   Genevisible; Q8IXS0; HS.
DR   InterPro; IPR029266; FAM217.
DR   PANTHER; PTHR22145; PTHR22145; 1.
DR   Pfam; PF15344; FAM217; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..508
FT                   /note="Protein FAM217A"
FT                   /id="PRO_0000089540"
FT   VARIANT         258
FT                   /note="A -> T (in dbSNP:rs639905)"
FT                   /id="VAR_056801"
FT   VARIANT         309
FT                   /note="Q -> P (in dbSNP:rs10080405)"
FT                   /id="VAR_056802"
FT   VARIANT         360
FT                   /note="C -> S (in dbSNP:rs17137618)"
FT                   /id="VAR_056803"
FT   VARIANT         431
FT                   /note="V -> I (in dbSNP:rs595413)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_023207"
FT   VARIANT         442
FT                   /note="M -> V (in dbSNP:rs10485172)"
FT                   /id="VAR_056804"
SQ   SEQUENCE   508 AA;  57420 MW;  883F88EFF7AC7D2C CRC64;
     MGRRNENCAN SLRVSNISQE NLSHWNLDSE VPVSENKNLP AGRDGAAGGK INKNYLEIPV
     EQLMLEPNLS VHSQKSTQNS KQGIFQLWNC PLNEGSTIEK REFKKSSVET GFNVINHPIR
     VFTLNHPLTI ASVDKQVGPY PGLPMPLGLC WPYADGDFFK NRNEIHVSSC STIENNDGET
     LPAPNWNLKH GNSSVEENFT DESDLSENEK TNDTLLSYFK KVDLNLKPET IKNVEEPFTE
     EPNEVFPYPD FLPPPFSALD LHNLALSKSD NWKVTVDPAE TSVEHLITRL LELERLQHMT
     IQKERPRLQT TFCTPAVTER PSSSKATPKV RQPKLCDSLS LQIPCVDKSQ EKSKNNSGSC
     KLEQNALKRN WSNAGKYRWN SRPLSLKSSS TPKQLIETYD KNPKSSILSP CQELSFKPTI
     GHTNQSMVKM VSTRCLPWRS PMPVSPIPLT FPENQKEEIK APKRNFGTKK KLYRQNIVLN
     RPFSIQKLNC LSPSLIAKDK CCSPIEQK