F217B_HUMAN
ID F217B_HUMAN Reviewed; 383 AA.
AC Q9NTX9; B3KWH1; Q9NTA3;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Protein FAM217B;
GN Name=FAM217B; Synonyms=C20orf177;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-383.
RC TISSUE=Kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP VARIANT [LARGE SCALE ANALYSIS] GLY-95.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- INTERACTION:
CC Q9NTX9; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-19153639, EBI-11954519;
CC Q9NTX9; Q92688: ANP32B; NbExp=3; IntAct=EBI-19153639, EBI-762428;
CC Q9NTX9; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-19153639, EBI-11524452;
CC Q9NTX9; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-19153639, EBI-8643161;
CC Q9NTX9; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-19153639, EBI-739879;
CC Q9NTX9; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-19153639, EBI-10171570;
CC Q9NTX9; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-19153639, EBI-5278764;
CC Q9NTX9; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-19153639, EBI-742102;
CC Q9NTX9; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-19153639, EBI-2549423;
CC Q9NTX9; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-19153639, EBI-739909;
CC Q9NTX9; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-19153639, EBI-77889;
CC Q9NTX9; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-19153639, EBI-6952711;
CC Q9NTX9; P62875: POLR2L; NbExp=3; IntAct=EBI-19153639, EBI-359527;
CC Q9NTX9; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-19153639, EBI-455078;
CC Q9NTX9; Q5MJ09: SPANXN3; NbExp=3; IntAct=EBI-19153639, EBI-12037215;
CC Q9NTX9; P51687: SUOX; NbExp=3; IntAct=EBI-19153639, EBI-3921347;
CC Q9NTX9; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-19153639, EBI-11955057;
CC Q9NTX9; Q08117-2: TLE5; NbExp=3; IntAct=EBI-19153639, EBI-11741437;
CC Q9NTX9; Q6DKK2: TTC19; NbExp=3; IntAct=EBI-19153639, EBI-948354;
CC Q9NTX9; Q05516: ZBTB16; NbExp=3; IntAct=EBI-19153639, EBI-711925;
CC -!- SIMILARITY: Belongs to the FAM217 family. {ECO:0000305}.
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DR EMBL; AK125073; BAG54133.1; -; mRNA.
DR EMBL; AL109928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75424.1; -; Genomic_DNA.
DR EMBL; BC054002; AAH54002.1; -; mRNA.
DR EMBL; AL137442; CAB70739.2; -; mRNA.
DR CCDS; CCDS13484.1; -.
DR PIR; T46282; T46282.
DR RefSeq; NP_001177755.1; NM_001190826.1.
DR RefSeq; NP_001177756.1; NM_001190827.1.
DR RefSeq; NP_071389.1; NM_022106.2.
DR AlphaFoldDB; Q9NTX9; -.
DR BioGRID; 122004; 38.
DR IntAct; Q9NTX9; 29.
DR STRING; 9606.ENSP00000351040; -.
DR iPTMnet; Q9NTX9; -.
DR PhosphoSitePlus; Q9NTX9; -.
DR BioMuta; FAM217B; -.
DR DMDM; 27734258; -.
DR MassIVE; Q9NTX9; -.
DR PaxDb; Q9NTX9; -.
DR PeptideAtlas; Q9NTX9; -.
DR PRIDE; Q9NTX9; -.
DR ProteomicsDB; 82644; -.
DR Antibodypedia; 48191; 28 antibodies from 8 providers.
DR DNASU; 63939; -.
DR Ensembl; ENST00000358293.7; ENSP00000351040.3; ENSG00000196227.11.
DR Ensembl; ENST00000360816.8; ENSP00000354056.3; ENSG00000196227.11.
DR GeneID; 63939; -.
DR KEGG; hsa:63939; -.
DR MANE-Select; ENST00000360816.8; ENSP00000354056.3; NM_022106.3; NP_071389.1.
DR UCSC; uc002yba.4; human.
DR CTD; 63939; -.
DR DisGeNET; 63939; -.
DR GeneCards; FAM217B; -.
DR HGNC; HGNC:16170; FAM217B.
DR HPA; ENSG00000196227; Low tissue specificity.
DR neXtProt; NX_Q9NTX9; -.
DR OpenTargets; ENSG00000196227; -.
DR PharmGKB; PA25720; -.
DR VEuPathDB; HostDB:ENSG00000196227; -.
DR eggNOG; ENOG502R40C; Eukaryota.
DR GeneTree; ENSGT00940000154543; -.
DR HOGENOM; CLU_043958_0_0_1; -.
DR InParanoid; Q9NTX9; -.
DR OMA; RPSYYAF; -.
DR PhylomeDB; Q9NTX9; -.
DR TreeFam; TF337855; -.
DR PathwayCommons; Q9NTX9; -.
DR SignaLink; Q9NTX9; -.
DR BioGRID-ORCS; 63939; 10 hits in 1081 CRISPR screens.
DR ChiTaRS; FAM217B; human.
DR GenomeRNAi; 63939; -.
DR Pharos; Q9NTX9; Tdark.
DR PRO; PR:Q9NTX9; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9NTX9; protein.
DR Bgee; ENSG00000196227; Expressed in endothelial cell and 185 other tissues.
DR ExpressionAtlas; Q9NTX9; baseline and differential.
DR Genevisible; Q9NTX9; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR029266; FAM217.
DR PANTHER; PTHR22145; PTHR22145; 1.
DR Pfam; PF15344; FAM217; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..383
FT /note="Protein FAM217B"
FT /id="PRO_0000079485"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 95
FT /note="S -> G (in a breast cancer sample; somatic mutation;
FT dbSNP:rs1180582304)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035691"
FT VARIANT 380
FT /note="Y -> C (in dbSNP:rs6027210)"
FT /id="VAR_050922"
FT CONFLICT 68
FT /note="Q -> G (in Ref. 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="E -> G (in Ref. 5; CAB70739)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 383 AA; 42052 MW; 56E1DB8E27CD544F CRC64;
MNAGPSWNKV QHSKNSSGKR QSKSQVPHAS SQPRSSLTAV TQPTEEKLKE SISPEARRKR
NPLGSRCQGA SGNKLFLDFQ SMKIIKENAD EDSASDLSDS ERIPIPPSPL TPPDLNLRAE
EIDPVYFDLH PGQGHTKPEY YYPNFLPSPF SSWDLRDMAL LLNAENKTEA VPRVGGLLGK
YIDRLIQLEW LQVQTVQCEK AKGGKARPPT APGTSGALKS PGRSKLIASA LSKPLPHQEG
ASKSGPSRKK AFHHEEIHPS HYAFETSPRP IDVLGGTRFC SQRQTLEMRT EEKKKKSSKS
TKLQRWDLSG SGSSSKVETS GHIRVPKQAA VILDSADSCK ASKTQAHAHP RKKGKAESCG
HATVSSEKKL KTNGVKQNTY KLK
