F219B_HUMAN
ID F219B_HUMAN Reviewed; 198 AA.
AC Q5XKK7; A8K4Q5; B4DK57; Q9NXY0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Protein FAM219B;
GN Name=FAM219B; Synonyms=C15orf17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-198 (ISOFORM 2).
RC TISSUE=Spleen;
RX PubMed=11214971; DOI=10.1093/dnares/7.6.357;
RA Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.;
RT "Characterization of long cDNA clones from human adult spleen.";
RL DNA Res. 7:357-366(2000).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125 AND SER-127, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-91, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q5XKK7; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-12290965, EBI-541426;
CC Q5XKK7; P49639: HOXA1; NbExp=3; IntAct=EBI-12290965, EBI-740785;
CC Q5XKK7; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12290965, EBI-16439278;
CC Q5XKK7; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-12290965, EBI-79165;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5XKK7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5XKK7-2; Sequence=VSP_019499, VSP_019500;
CC Name=3;
CC IsoId=Q5XKK7-3; Sequence=VSP_036115, VSP_036116;
CC -!- SIMILARITY: Belongs to the FAM219 family. {ECO:0000305}.
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DR EMBL; AK000005; BAA92230.1; -; mRNA.
DR EMBL; AK291020; BAF83709.1; -; mRNA.
DR EMBL; AK296403; BAG59069.1; -; mRNA.
DR EMBL; AC125435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471136; EAW99292.1; -; Genomic_DNA.
DR EMBL; BC015637; AAH15637.1; -; mRNA.
DR CCDS; CCDS32295.1; -. [Q5XKK7-1]
DR RefSeq; NP_001308849.1; NM_001321920.1. [Q5XKK7-1]
DR RefSeq; NP_001308850.1; NM_001321921.1. [Q5XKK7-1]
DR RefSeq; NP_065180.1; NM_020447.4. [Q5XKK7-1]
DR AlphaFoldDB; Q5XKK7; -.
DR BioGRID; 121433; 21.
DR IntAct; Q5XKK7; 10.
DR STRING; 9606.ENSP00000350260; -.
DR GlyGen; Q5XKK7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5XKK7; -.
DR PhosphoSitePlus; Q5XKK7; -.
DR SwissPalm; Q5XKK7; -.
DR BioMuta; FAM219B; -.
DR DMDM; 74736248; -.
DR EPD; Q5XKK7; -.
DR jPOST; Q5XKK7; -.
DR MassIVE; Q5XKK7; -.
DR MaxQB; Q5XKK7; -.
DR PaxDb; Q5XKK7; -.
DR PeptideAtlas; Q5XKK7; -.
DR PRIDE; Q5XKK7; -.
DR ProteomicsDB; 65827; -. [Q5XKK7-1]
DR ProteomicsDB; 65828; -. [Q5XKK7-2]
DR ProteomicsDB; 65829; -. [Q5XKK7-3]
DR TopDownProteomics; Q5XKK7-2; -. [Q5XKK7-2]
DR Antibodypedia; 55534; 12 antibodies from 5 providers.
DR DNASU; 57184; -.
DR Ensembl; ENST00000357635.10; ENSP00000350260.5; ENSG00000178761.15. [Q5XKK7-1]
DR Ensembl; ENST00000563069.5; ENSP00000457594.1; ENSG00000178761.15. [Q5XKK7-3]
DR Ensembl; ENST00000563119.5; ENSP00000454719.1; ENSG00000178761.15. [Q5XKK7-1]
DR GeneID; 57184; -.
DR KEGG; hsa:57184; -.
DR MANE-Select; ENST00000357635.10; ENSP00000350260.5; NM_020447.5; NP_065180.1.
DR UCSC; uc002azf.4; human. [Q5XKK7-1]
DR CTD; 57184; -.
DR DisGeNET; 57184; -.
DR GeneCards; FAM219B; -.
DR HGNC; HGNC:24695; FAM219B.
DR HPA; ENSG00000178761; Low tissue specificity.
DR neXtProt; NX_Q5XKK7; -.
DR OpenTargets; ENSG00000178761; -.
DR PharmGKB; PA134953632; -.
DR VEuPathDB; HostDB:ENSG00000178761; -.
DR eggNOG; ENOG502S0AN; Eukaryota.
DR GeneTree; ENSGT00390000000860; -.
DR InParanoid; Q5XKK7; -.
DR OMA; VMHQPRQ; -.
DR OrthoDB; 1535162at2759; -.
DR PhylomeDB; Q5XKK7; -.
DR TreeFam; TF331928; -.
DR PathwayCommons; Q5XKK7; -.
DR SignaLink; Q5XKK7; -.
DR BioGRID-ORCS; 57184; 9 hits in 1075 CRISPR screens.
DR ChiTaRS; FAM219B; human.
DR GenomeRNAi; 57184; -.
DR Pharos; Q5XKK7; Tdark.
DR PRO; PR:Q5XKK7; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q5XKK7; protein.
DR Bgee; ENSG00000178761; Expressed in tendon of biceps brachii and 179 other tissues.
DR ExpressionAtlas; Q5XKK7; baseline and differential.
DR Genevisible; Q5XKK7; HS.
DR InterPro; IPR029339; FAM219.
DR PANTHER; PTHR31281; PTHR31281; 1.
DR Pfam; PF15260; FAM219A; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..198
FT /note="Protein FAM219B"
FT /id="PRO_0000243930"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 14
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 91
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 125
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 127
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VAR_SEQ 103..113
FT /note="VKFNKGYTALS -> QQAPPPLCQQL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11214971"
FT /id="VSP_019499"
FT VAR_SEQ 114..198
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11214971"
FT /id="VSP_019500"
FT VAR_SEQ 127..148
FT /note="SDGELGSRYSSGYSSAEQVNQD -> RPFMYIPGPFSSEQYPFPGWLG (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036115"
FT VAR_SEQ 149..198
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036116"
SQ SEQUENCE 198 AA; 21103 MW; 09B6208FA3307A87 CRC64;
MATAEPSGRA LRLSTPGPRP SGARDRAPGA AGPPSGQIGN RALRLGERTP AAVEKRGPYM
VTRAPSIQAK LQKHRDLAKA VLRRKGMLGA SPNRPDSSGK RSVKFNKGYT ALSQSPDENL
VSLDSDSDGE LGSRYSSGYS SAEQVNQDVS RQLLQDGYHL DEIPDDEDLD LIPPKPMASS
TCSCCWCCLG DSSSCTLQ
