F219B_MOUSE
ID F219B_MOUSE Reviewed; 197 AA.
AC Q14DQ1; Q8BSZ6;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Protein FAM219B;
GN Name=Fam219b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125 AND SER-127, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14DQ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14DQ1-2; Sequence=VSP_036130, VSP_036131;
CC -!- SIMILARITY: Belongs to the FAM219 family. {ECO:0000305}.
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DR EMBL; AK028365; BAC25905.1; -; mRNA.
DR EMBL; AC164548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466522; EDL25908.1; -; Genomic_DNA.
DR EMBL; BC111883; AAI11884.1; -; mRNA.
DR EMBL; BC112403; AAI12404.1; -; mRNA.
DR CCDS; CCDS52807.1; -. [Q14DQ1-1]
DR CCDS; CCDS52808.1; -. [Q14DQ1-2]
DR RefSeq; NP_001159836.1; NM_001166364.1. [Q14DQ1-1]
DR RefSeq; NP_780482.1; NM_175273.4. [Q14DQ1-2]
DR AlphaFoldDB; Q14DQ1; -.
DR iPTMnet; Q14DQ1; -.
DR PhosphoSitePlus; Q14DQ1; -.
DR EPD; Q14DQ1; -.
DR MaxQB; Q14DQ1; -.
DR PaxDb; Q14DQ1; -.
DR PeptideAtlas; Q14DQ1; -.
DR PRIDE; Q14DQ1; -.
DR ProteomicsDB; 275515; -. [Q14DQ1-1]
DR ProteomicsDB; 275516; -. [Q14DQ1-2]
DR Antibodypedia; 55534; 12 antibodies from 5 providers.
DR Ensembl; ENSMUST00000093833; ENSMUSP00000091353; ENSMUSG00000032305. [Q14DQ1-2]
DR Ensembl; ENSMUST00000114200; ENSMUSP00000109838; ENSMUSG00000032305. [Q14DQ1-1]
DR GeneID; 78323; -.
DR KEGG; mmu:78323; -.
DR UCSC; uc009pva.2; mouse. [Q14DQ1-2]
DR UCSC; uc009pvb.2; mouse. [Q14DQ1-1]
DR CTD; 57184; -.
DR MGI; MGI:1925573; Fam219b.
DR VEuPathDB; HostDB:ENSMUSG00000032305; -.
DR eggNOG; ENOG502S0AN; Eukaryota.
DR GeneTree; ENSGT00390000000860; -.
DR HOGENOM; CLU_118636_1_0_1; -.
DR InParanoid; Q14DQ1; -.
DR OMA; VMHQPRQ; -.
DR OrthoDB; 1535162at2759; -.
DR PhylomeDB; Q14DQ1; -.
DR TreeFam; TF331928; -.
DR BioGRID-ORCS; 78323; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Fam219b; mouse.
DR PRO; PR:Q14DQ1; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q14DQ1; protein.
DR Bgee; ENSMUSG00000032305; Expressed in humerus cartilage element and 212 other tissues.
DR Genevisible; Q14DQ1; MM.
DR InterPro; IPR029339; FAM219.
DR PANTHER; PTHR31281; PTHR31281; 1.
DR Pfam; PF15260; FAM219A; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..197
FT /note="Protein FAM219B"
FT /id="PRO_0000358919"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 14
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XKK7"
FT MOD_RES 125
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 127
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 128
FT /note="D -> R (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_036130"
FT VAR_SEQ 129..197
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_036131"
SQ SEQUENCE 197 AA; 21006 MW; 1C57A1BD17C476F6 CRC64;
MATEEFRGHA VRMSTQGSQP GAAPDSVAGT AGLPSGQSGG AGLRLGERPP PAMEKRGPYL
VTRAPSIQAK LKKHRDHAKA VLRRKGMLGA LTNRPDSSGK RSVKFNKGYT ALSQSPDENL
VSLDSDSDGE LESRYSSGYS SAEQVNQDVS RQLLQDGYHL DEIPDDEDLD LIPPKPIASS
ACSCCWCCLG DSSCTLQ
