F220A_HUMAN
ID F220A_HUMAN Reviewed; 259 AA.
AC Q7Z4H9; Q75ML2; Q8NA52; Q9BRR7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein FAM220A;
DE AltName: Full=STAT3-interacting protein as a repressor;
GN Name=FAM220A; Synonyms=C7orf70, SIPAR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Ding P., Han W., Xia D., Liu Y., Wu C., Shi S., Ma D.;
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLN-127; LEU-161 AND
RP MET-198.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS GLN-127;
RP LEU-161 AND MET-198.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May negatively regulate STAT3. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with STAT3. {ECO:0000250}.
CC -!- INTERACTION:
CC Q7Z4H9; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-12871772, EBI-11750983;
CC Q7Z4H9; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-12871772, EBI-750487;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS07509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAG34819.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR EMBL; AF533707; AAQ09020.1; -; mRNA.
DR EMBL; AK093156; BAC04076.1; -; mRNA.
DR EMBL; AK311878; BAG34819.1; ALT_SEQ; mRNA.
DR EMBL; AC009412; AAS07509.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH878731; EAW55045.1; -; Genomic_DNA.
DR EMBL; BC006110; AAH06110.2; -; mRNA.
DR EMBL; BC142977; AAI42978.1; -; mRNA.
DR CCDS; CCDS34599.1; -.
DR RefSeq; NP_001032240.1; NM_001037163.1.
DR AlphaFoldDB; Q7Z4H9; -.
DR BioGRID; 124261; 3.
DR IntAct; Q7Z4H9; 2.
DR STRING; 9606.ENSP00000317289; -.
DR iPTMnet; Q7Z4H9; -.
DR PhosphoSitePlus; Q7Z4H9; -.
DR BioMuta; FAM220A; -.
DR DMDM; 74713515; -.
DR MassIVE; Q7Z4H9; -.
DR PaxDb; Q7Z4H9; -.
DR PeptideAtlas; Q7Z4H9; -.
DR PRIDE; Q7Z4H9; -.
DR Antibodypedia; 71301; 17 antibodies from 7 providers.
DR DNASU; 84792; -.
DR Ensembl; ENST00000313324.9; ENSP00000317289.4; ENSG00000178397.13.
DR GeneID; 84792; -.
DR KEGG; hsa:84792; -.
DR MANE-Select; ENST00000313324.9; ENSP00000317289.4; NM_001037163.2; NP_001032240.1.
DR UCSC; uc003spu.3; human.
DR CTD; 84792; -.
DR GeneCards; FAM220A; -.
DR HGNC; HGNC:22422; FAM220A.
DR HPA; ENSG00000178397; Tissue enhanced (skeletal muscle, testis).
DR MIM; 616628; gene.
DR neXtProt; NX_Q7Z4H9; -.
DR OpenTargets; ENSG00000178397; -.
DR PharmGKB; PA165617654; -.
DR VEuPathDB; HostDB:ENSG00000178397; -.
DR eggNOG; ENOG502S2EY; Eukaryota.
DR GeneTree; ENSGT00390000014156; -.
DR HOGENOM; CLU_089176_0_0_1; -.
DR InParanoid; Q7Z4H9; -.
DR OMA; DRLKPMF; -.
DR OrthoDB; 1192696at2759; -.
DR PhylomeDB; Q7Z4H9; -.
DR TreeFam; TF336869; -.
DR PathwayCommons; Q7Z4H9; -.
DR SignaLink; Q7Z4H9; -.
DR BioGRID-ORCS; 84792; 14 hits in 1046 CRISPR screens.
DR GenomeRNAi; 84792; -.
DR Pharos; Q7Z4H9; Tdark.
DR PRO; PR:Q7Z4H9; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q7Z4H9; protein.
DR Bgee; ENSG00000178397; Expressed in secondary oocyte and 188 other tissues.
DR ExpressionAtlas; Q7Z4H9; baseline and differential.
DR Genevisible; Q7Z4H9; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0097677; F:STAT family protein binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR InterPro; IPR040355; FAM220A.
DR InterPro; IPR029155; SIPAR.
DR PANTHER; PTHR31980; PTHR31980; 1.
DR Pfam; PF15487; FAM220; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..259
FT /note="Protein FAM220A"
FT /id="PRO_0000321923"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 71
FT /note="G -> R (in dbSNP:rs3750041)"
FT /id="VAR_039375"
FT VARIANT 127
FT /note="R -> Q (in dbSNP:rs3750040)"
FT /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.4"
FT /id="VAR_039376"
FT VARIANT 161
FT /note="V -> L (in dbSNP:rs3750039)"
FT /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.4"
FT /id="VAR_039377"
FT VARIANT 198
FT /note="V -> M (in dbSNP:rs6952125)"
FT /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.4"
FT /id="VAR_039378"
FT VARIANT 237
FT /note="G -> S (in dbSNP:rs2241445)"
FT /id="VAR_039379"
SQ SEQUENCE 259 AA; 28021 MW; F649BE355ADBF5E9 CRC64;
MRDRRGPLGT CLAQVQQAGG GDSDKLSCSL KKRMPEGPWP ADAPSWMNKP VVDGNSQSEA
LSLEMRKDPS GAGLWLHSGG PVLPYVRESV RRNPASAATP STAVGLFPAP TECFARVSCS
GVEALGRRDW LGGGPRATDG HRGQCPKGEP RVSRLPRHQK VPEMGSFQDD PPSAFPKGLG
SELEPACLHS ILSATLHVYP EVLLSEETKR IFLDRLKPMF SKQTIEFKKM LKSTSDGLQI
TLGLLALQPF ELANTLCHS
