ID   F220A_MACFA             Reviewed;         259 AA.
AC   Q4R3X9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Protein FAM220A;
DE   AltName: Full=STAT3-interacting protein as a repressor;
GN   Name=FAM220A; Synonyms=SIPAR; ORFNames=QtsA-13353;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May negatively regulate STAT3. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STAT3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AB179136; BAE02187.1; -; mRNA.
DR   RefSeq; NP_001271877.1; NM_001284948.1.
DR   AlphaFoldDB; Q4R3X9; -.
DR   GeneID; 101866180; -.
DR   CTD; 84792; -.
DR   eggNOG; ENOG502S2EY; Eukaryota.
DR   OrthoDB; 1192696at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR040355; FAM220A.
DR   InterPro; IPR029155; SIPAR.
DR   PANTHER; PTHR31980; PTHR31980; 1.
DR   Pfam; PF15487; FAM220; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..259
FT                   /note="Protein FAM220A"
FT                   /id="PRO_0000321924"
SQ   SEQUENCE   259 AA;  28027 MW;  1F44306CB52F086D CRC64;
     MRDRRGSLGT CLAQVQQARG GDSNKLSYSL KKRMPMEGLW PADAPSWMNK PVVDGNSQSE
     ALSLEMRKDP SGAGPWLHGG GPVLPYVKES VRRNPASAAT RSTAVGLLPA PTECFAQVAC
     SGVEALERDW LGGGARATDG HRGQCPKGEP RVSRLLCHQK LPEMGSFQDD PPNALPKGLG
     SELEPSCLHS VLSATLHACP EVLLNDETKR VFLDRLKPMF SKQTMEFKKM LKNTSDGLQI
     TLGLLALQPF ELANSLCHS