F220A_MOUSE
ID F220A_MOUSE Reviewed; 260 AA.
AC Q3ZN08; B2RVG9; Q8BPE1; Q99JV7; Q9D5Z1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Protein FAM220A;
DE AltName: Full=Acrosomal protein ACPIN1;
DE AltName: Full=STAT3-interacting protein as a repressor;
GN Name=Fam220a; Synonyms=Acpin1, Sipar;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND INTERACTION WITH
RP STAT3.
RC STRAIN=Swiss Webster / NIH;
RA Ning H., Rong Y., Zhang Y., Chang Z.;
RT "SIPAR interacts with STAT3 to regulate its signal pathway.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Ueda T., Manabe H., Hirose M., Tokuhiro K., Matsuoka Y., Miyagawa Y.,
RA Tsujimura A., Okuyama A., Nishimune Y., Tanaka H.;
RT "Isolation and characterization of a novel cDNA encoding an acrosomal
RT protein (ACPIN1) and salivary gland specific protein (SAGSIN1): each
RT protein was alternatively translated from two open reading frames on Acpin1
RT mRNA.";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May negatively regulate STAT3.
CC -!- SUBUNIT: Interacts with STAT3. {ECO:0000269|Ref.1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|Ref.1}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH05638.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AY714985; AAW31134.1; -; mRNA.
DR EMBL; AB374429; BAH02665.1; -; mRNA.
DR EMBL; AK076127; BAC36204.1; -; mRNA.
DR EMBL; AK156614; BAE33776.1; -; mRNA.
DR EMBL; AK014805; BAB29560.1; -; mRNA.
DR EMBL; BC005638; AAH05638.2; ALT_INIT; mRNA.
DR EMBL; BC147186; AAI47187.1; -; mRNA.
DR EMBL; BC147187; AAI47188.1; -; mRNA.
DR CCDS; CCDS51690.1; -.
DR RefSeq; NP_080326.2; NM_026050.2.
DR RefSeq; NP_598464.3; NM_133703.4.
DR AlphaFoldDB; Q3ZN08; -.
DR STRING; 10090.ENSMUSP00000126480; -.
DR PhosphoSitePlus; Q3ZN08; -.
DR PaxDb; Q3ZN08; -.
DR PRIDE; Q3ZN08; -.
DR DNASU; 67238; -.
DR Ensembl; ENSMUST00000067145; ENSMUSP00000063424; ENSMUSG00000118332.
DR Ensembl; ENSMUST00000169329; ENSMUSP00000126480; ENSMUSG00000118332.
DR Ensembl; ENSMUST00000196487; ENSMUSP00000143202; ENSMUSG00000083012.
DR Ensembl; ENSMUST00000200267; ENSMUSP00000142548; ENSMUSG00000083012.
DR GeneID; 67238; -.
DR KEGG; mmu:67238; -.
DR UCSC; uc009akm.2; mouse.
DR CTD; 84792; -.
DR MGI; MGI:1914488; Fam220a.
DR VEuPathDB; HostDB:ENSMUSG00000083012; -.
DR VEuPathDB; HostDB:ENSMUSG00000118332; -.
DR eggNOG; ENOG502S2EY; Eukaryota.
DR GeneTree; ENSGT00390000014156; -.
DR HOGENOM; CLU_089176_0_0_1; -.
DR InParanoid; Q3ZN08; -.
DR OMA; DRLKPMF; -.
DR OrthoDB; 1192696at2759; -.
DR PhylomeDB; Q3ZN08; -.
DR TreeFam; TF336869; -.
DR BioGRID-ORCS; 67238; 2 hits in 25 CRISPR screens.
DR ChiTaRS; Fam220a; mouse.
DR PRO; PR:Q3ZN08; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q3ZN08; protein.
DR Bgee; ENSMUSG00000083012; Expressed in animal zygote and 60 other tissues.
DR Genevisible; Q3ZN08; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0097677; F:STAT family protein binding; IPI:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IPI:MGI.
DR GO; GO:0032092; P:positive regulation of protein binding; IMP:MGI.
DR GO; GO:0006470; P:protein dephosphorylation; IDA:MGI.
DR InterPro; IPR040355; FAM220A.
DR InterPro; IPR029155; SIPAR.
DR PANTHER; PTHR31980; PTHR31980; 1.
DR Pfam; PF15487; FAM220; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..260
FT /note="Protein FAM220A"
FT /id="PRO_0000321925"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 59
FT /note="A -> P (in Ref. 3; BAC36204)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="A -> S (in Ref. 3; BAB29560)"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="D -> G (in Ref. 3; BAB29560)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 260 AA; 27752 MW; 0A606ED8E1920699 CRC64;
MKAGRGTLGV CLAKQSQGGD PDKLACGLKK RSQKRNPSPS VVPSWTDQPV ADSHGKSRAT
GAAASEMKHG QSKASLLHHG GFKVLQSLKG SVGRSSAPAA SLGKAVALSP APSEEQLAGM
SHGIGDALGS DWPGREPRAT DNRGQYLKGE SWVSGRPGHP KLREVGFLRG EPPSAGPKGL
GTWSELSHRY FELGQLPYAY PYYKVLPEGE LRCVSLDRFN PGLSEETVED EKTLKFFRWS
ADSRGVTGSA IFQISKSLMP
