ID   F220A_RAT               Reviewed;         259 AA.
AC   Q6DGF6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Protein FAM220A;
DE   AltName: Full=STAT3-interacting protein as a repressor;
GN   Name=Fam220a; Synonyms=Sipar;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May negatively regulate STAT3. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STAT3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC076392; AAH76392.1; -; mRNA.
DR   RefSeq; NP_001017485.1; NM_001017485.1.
DR   AlphaFoldDB; Q6DGF6; -.
DR   STRING; 10116.ENSRNOP00000059765; -.
DR   PhosphoSitePlus; Q6DGF6; -.
DR   PaxDb; Q6DGF6; -.
DR   Ensembl; ENSRNOT00000029692; ENSRNOP00000059765; ENSRNOG00000024605.
DR   Ensembl; ENSRNOT00000102797; ENSRNOP00000078852; ENSRNOG00000024605.
DR   GeneID; 498145; -.
DR   KEGG; rno:498145; -.
DR   CTD; 84792; -.
DR   RGD; 1561923; Fam220a.
DR   eggNOG; ENOG502S2EY; Eukaryota.
DR   GeneTree; ENSGT00390000014156; -.
DR   HOGENOM; CLU_089176_0_0_1; -.
DR   InParanoid; Q6DGF6; -.
DR   OMA; DRLKPMF; -.
DR   OrthoDB; 1192696at2759; -.
DR   PhylomeDB; Q6DGF6; -.
DR   TreeFam; TF336869; -.
DR   PRO; PR:Q6DGF6; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000024605; Expressed in testis and 20 other tissues.
DR   Genevisible; Q6DGF6; RN.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0097677; F:STAT family protein binding; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0032092; P:positive regulation of protein binding; ISO:RGD.
DR   GO; GO:0006470; P:protein dephosphorylation; ISO:RGD.
DR   InterPro; IPR040355; FAM220A.
DR   InterPro; IPR029155; SIPAR.
DR   PANTHER; PTHR31980; PTHR31980; 1.
DR   Pfam; PF15487; FAM220; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..259
FT                   /note="Protein FAM220A"
FT                   /id="PRO_0000321926"
FT   REGION          29..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   259 AA;  27739 MW;  78D58B644FD02ED2 CRC64;
     MRAGRGTLGV CLASVKQSQG GDLDKLACGL KRRSEKRNPS PSDVPSWTDQ PVADTHGKSR
     AMAAASSEMK RDQSKASLIL HSGFKALQYL KESMGRNSTP AASLSMAVVL SSAPSEEHGA
     GVSGGIGDTL GSDWPAREPR TTDSCGQYLK GEAWVSGWQG HPKVREVGFL RGEPLSAVPK
     GLGTRSELSY CSELCQLPYT YPYYEALPED KTRCVSLDHL SPVFSEETVE DEKTLSSTSD
     GLQIVMGLLA LQSSRLTSL