F221A_MOUSE
ID F221A_MOUSE Reviewed; 301 AA.
AC Q8C790; Q7TML5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein FAM221A;
GN Name=Fam221a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C790-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C790-2; Sequence=VSP_026740, VSP_026741;
CC -!- SIMILARITY: Belongs to the FAM221 family. {ECO:0000305}.
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DR EMBL; AK052323; BAC34936.1; -; mRNA.
DR EMBL; BC055818; AAH55818.1; -; mRNA.
DR CCDS; CCDS20126.1; -. [Q8C790-1]
DR CCDS; CCDS51769.1; -. [Q8C790-2]
DR RefSeq; NP_001165687.1; NM_001172216.1. [Q8C790-2]
DR RefSeq; NP_766315.1; NM_172727.3. [Q8C790-1]
DR RefSeq; XP_006506003.1; XM_006505940.3. [Q8C790-1]
DR RefSeq; XP_006506004.1; XM_006505941.3. [Q8C790-1]
DR AlphaFoldDB; Q8C790; -.
DR STRING; 10090.ENSMUSP00000050237; -.
DR iPTMnet; Q8C790; -.
DR PhosphoSitePlus; Q8C790; -.
DR EPD; Q8C790; -.
DR MaxQB; Q8C790; -.
DR PaxDb; Q8C790; -.
DR PeptideAtlas; Q8C790; -.
DR PRIDE; Q8C790; -.
DR ProteomicsDB; 271535; -. [Q8C790-1]
DR ProteomicsDB; 271536; -. [Q8C790-2]
DR Antibodypedia; 12123; 40 antibodies from 9 providers.
DR Ensembl; ENSMUST00000060561; ENSMUSP00000050237; ENSMUSG00000047115. [Q8C790-1]
DR Ensembl; ENSMUST00000121903; ENSMUSP00000113242; ENSMUSG00000047115. [Q8C790-2]
DR GeneID; 231946; -.
DR KEGG; mmu:231946; -.
DR UCSC; uc009bwr.2; mouse. [Q8C790-1]
DR UCSC; uc012elr.1; mouse. [Q8C790-2]
DR CTD; 340277; -.
DR MGI; MGI:2442161; Fam221a.
DR VEuPathDB; HostDB:ENSMUSG00000047115; -.
DR eggNOG; ENOG502QR3M; Eukaryota.
DR GeneTree; ENSGT00770000120611; -.
DR HOGENOM; CLU_080852_0_0_1; -.
DR InParanoid; Q8C790; -.
DR OMA; ALPCRVK; -.
DR OrthoDB; 973186at2759; -.
DR PhylomeDB; Q8C790; -.
DR TreeFam; TF329392; -.
DR BioGRID-ORCS; 231946; 1 hit in 70 CRISPR screens.
DR PRO; PR:Q8C790; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8C790; protein.
DR Bgee; ENSMUSG00000047115; Expressed in spermatocyte and 147 other tissues.
DR ExpressionAtlas; Q8C790; baseline and differential.
DR Genevisible; Q8C790; MM.
DR InterPro; IPR026755; Fam221a/b.
DR PANTHER; PTHR31214; PTHR31214; 1.
DR Pfam; PF14753; FAM221; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..301
FT /note="Protein FAM221A"
FT /id="PRO_0000295140"
FT REGION 235..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 252..258
FT /note="VGPSTQL -> DKAGKGC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026740"
FT VAR_SEQ 259..301
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026741"
SQ SEQUENCE 301 AA; 33346 MW; 9E1ED52366F57005 CRC64;
MERLTLPPGG AEAVDEYLEY RRIVGEDDGG KLFTPEEYEE YKKKVLPMRL QNRLFVSWRS
PTGMDCKLVG PETLCFCTHR YKQHKTDFET IPQQRPIALP CRVSGCRCKA YHYVPLNGTQ
PIRCRCKHFA DQHSAALGFT CNACSKCSGF HSCYTCACGQ PAYAHDTVVE TRQERLAQGK
PVGRDVPYAA MGGLTGFSSL AEGYMRLDDS GIGAPSVEVL DSAVSAMDHP FLRAMHAPST
SSPQPLAGGN EVGPSTQLSS LRKPEEDDMA YFERQYQERI KLEKAAKQKG KVPPLPSTKP
S
