F221A_RAT
ID F221A_RAT Reviewed; 296 AA.
AC Q4V8D7;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Protein FAM221A;
GN Name=Fam221a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-296.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the FAM221 family. {ECO:0000305}.
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DR EMBL; AABR03032211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC097434; AAH97434.1; -; mRNA.
DR RefSeq; NP_001020942.1; NM_001025771.2.
DR RefSeq; XP_017448282.1; XM_017592793.1.
DR AlphaFoldDB; Q4V8D7; -.
DR PaxDb; Q4V8D7; -.
DR GeneID; 500118; -.
DR KEGG; rno:500118; -.
DR UCSC; RGD:1563175; rat.
DR CTD; 340277; -.
DR RGD; 1563175; Fam221a.
DR VEuPathDB; HostDB:ENSRNOG00000009447; -.
DR eggNOG; ENOG502QR3M; Eukaryota.
DR HOGENOM; CLU_080852_0_0_1; -.
DR InParanoid; Q4V8D7; -.
DR OMA; ALPCRVK; -.
DR OrthoDB; 973186at2759; -.
DR PhylomeDB; Q4V8D7; -.
DR PRO; PR:Q4V8D7; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000009447; Expressed in testis and 15 other tissues.
DR ExpressionAtlas; Q4V8D7; baseline and differential.
DR Genevisible; Q4V8D7; RN.
DR InterPro; IPR026755; Fam221a/b.
DR PANTHER; PTHR31214; PTHR31214; 1.
DR Pfam; PF14753; FAM221; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..296
FT /note="Protein FAM221A"
FT /id="PRO_0000295141"
FT REGION 235..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 296 AA; 32904 MW; 67BF69A69EF841CC CRC64;
MERLTLPPGG AQAVDEYLEY RRIVGEDDGG KLFTPEEYEE YKKKVLPMRL QNRLFVSWRS
PTGMDCKLVG PETLCFCTHR YKQHKTDFET VPQQRPIDLP CRVTGCQCKA YHYVPLNGTQ
PIRCRCKHFA DQHSPALGFT CNACSKCSGF HSCFTCACGQ PAYAHDTVVE TRQERLAQGK
PVGQDVPYAA MGGLTGFSSL AEGYMRLDDS GIGAPSVDVL DSPVSVMDHP FLRAMQPPST
SSPQPLAVGP STQISSLRKP EEDDMAYFER QYQERIKMEK AAKKGKALPP PSTQPS
