ID   F221B_RAT               Reviewed;         507 AA.
AC   Q66HD8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Protein FAM221B;
GN   Name=Fam221b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SIMILARITY: Belongs to the FAM221 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC081906; AAH81906.1; -; mRNA.
DR   RefSeq; NP_001013956.2; NM_001013934.2.
DR   AlphaFoldDB; Q66HD8; -.
DR   STRING; 10116.ENSRNOP00000031403; -.
DR   CarbonylDB; Q66HD8; -.
DR   iPTMnet; Q66HD8; -.
DR   PhosphoSitePlus; Q66HD8; -.
DR   PaxDb; Q66HD8; -.
DR   GeneID; 298398; -.
DR   KEGG; rno:298398; -.
DR   UCSC; RGD:1310425; rat.
DR   CTD; 392307; -.
DR   RGD; 1310425; Fam221b.
DR   eggNOG; ENOG502R7X0; Eukaryota.
DR   HOGENOM; CLU_053868_1_0_1; -.
DR   InParanoid; Q66HD8; -.
DR   OrthoDB; 973186at2759; -.
DR   PhylomeDB; Q66HD8; -.
DR   TreeFam; TF328347; -.
DR   PRO; PR:Q66HD8; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q66HD8; RN.
DR   InterPro; IPR026755; Fam221a/b.
DR   PANTHER; PTHR31214; PTHR31214; 1.
DR   Pfam; PF14753; FAM221; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..507
FT                   /note="Protein FAM221B"
FT                   /id="PRO_0000309266"
FT   REGION          1..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          154..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..310
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         270
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   507 AA;  57157 MW;  40C0F989A24CBB55 CRC64;
     MEADKTSEGP PATQDAKKHP SLTVPHAEDL PEATTPESPP HLLSSQEYFQ PPKVHSKTYP
     SLDLGTKDSE DLQDPSVSET PLKLDTANLP STPSQSSAQS VISLERAISK IPLDDFIYEN
     SISEVQEEPL PLSPTTDISK YEYPISDVQE EPLLLSPTTN ISKYEDSISD VQEEPLEDTP
     TADISETEYS ISDVQEEPLE PPPTADIPES EDYISDDHEE PLEPPPTADI PESSYEFISD
     KVPQTQVPES EPFPKHSVPE PSAQAKEAAS ADEEEAEEEE LTGGTSKTAA AGSEHHARKK
     KEKRGCESRP VVPAKRAELV EMAKAMHRKQ FDDQVNDLFQ WEKNSSLKAI QTGIYIGWRC
     PHYLWDCFRI GDESKCFCGH LLKEHQIISD LSVPCSVSQC RCLMFCFIPS RPEEVGEFWL
     KKRATFDPKA WRAQCRCKHT HEEHAATGSH PCRHRGCYCN SFESNFLCAA CDRRWEEHET
     FFETEETKRR GKRPYGTNTA KNRHRPF