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F222A_HUMAN
ID   F222A_HUMAN             Reviewed;         452 AA.
AC   Q5U5X8; Q8NCD5; Q96SP6;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Protein FAM222A;
GN   Name=FAM222A; Synonyms=C12orf34;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the FAM222 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC11219.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK027627; BAB55244.1; -; mRNA.
DR   EMBL; AK074806; BAC11219.1; ALT_INIT; mRNA.
DR   EMBL; AC007834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC037221; AAH37221.1; -; mRNA.
DR   CCDS; CCDS9133.1; -.
DR   RefSeq; NP_116218.2; NM_032829.2.
DR   RefSeq; XP_006719717.1; XM_006719654.2.
DR   RefSeq; XP_016875544.1; XM_017020055.1.
DR   AlphaFoldDB; Q5U5X8; -.
DR   BioGRID; 124352; 13.
DR   IntAct; Q5U5X8; 7.
DR   STRING; 9606.ENSP00000443292; -.
DR   iPTMnet; Q5U5X8; -.
DR   PhosphoSitePlus; Q5U5X8; -.
DR   BioMuta; FAM222A; -.
DR   DMDM; 74736192; -.
DR   MassIVE; Q5U5X8; -.
DR   PaxDb; Q5U5X8; -.
DR   PeptideAtlas; Q5U5X8; -.
DR   PRIDE; Q5U5X8; -.
DR   ProteomicsDB; 65233; -.
DR   Antibodypedia; 48247; 32 antibodies from 12 providers.
DR   DNASU; 84915; -.
DR   Ensembl; ENST00000358906.3; ENSP00000351783.3; ENSG00000139438.6.
DR   Ensembl; ENST00000538780.2; ENSP00000443292.1; ENSG00000139438.6.
DR   GeneID; 84915; -.
DR   KEGG; hsa:84915; -.
DR   MANE-Select; ENST00000538780.2; ENSP00000443292.1; NM_032829.3; NP_116218.2.
DR   UCSC; uc001tpd.3; human.
DR   CTD; 84915; -.
DR   DisGeNET; 84915; -.
DR   GeneCards; FAM222A; -.
DR   HGNC; HGNC:25915; FAM222A.
DR   HPA; ENSG00000139438; Tissue enhanced (brain).
DR   neXtProt; NX_Q5U5X8; -.
DR   OpenTargets; ENSG00000139438; -.
DR   PharmGKB; PA143485364; -.
DR   VEuPathDB; HostDB:ENSG00000139438; -.
DR   eggNOG; ENOG502QPV4; Eukaryota.
DR   GeneTree; ENSGT00530000063811; -.
DR   HOGENOM; CLU_027495_1_0_1; -.
DR   InParanoid; Q5U5X8; -.
DR   OMA; PRKCETA; -.
DR   OrthoDB; 507523at2759; -.
DR   PhylomeDB; Q5U5X8; -.
DR   TreeFam; TF331508; -.
DR   PathwayCommons; Q5U5X8; -.
DR   SignaLink; Q5U5X8; -.
DR   BioGRID-ORCS; 84915; 9 hits in 1075 CRISPR screens.
DR   ChiTaRS; FAM222A; human.
DR   GenomeRNAi; 84915; -.
DR   Pharos; Q5U5X8; Tdark.
DR   PRO; PR:Q5U5X8; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q5U5X8; protein.
DR   Bgee; ENSG00000139438; Expressed in C1 segment of cervical spinal cord and 132 other tissues.
DR   ExpressionAtlas; Q5U5X8; baseline and differential.
DR   Genevisible; Q5U5X8; HS.
DR   InterPro; IPR029340; FAM222.
DR   PANTHER; PTHR16070; PTHR16070; 1.
DR   Pfam; PF15258; FAM222A; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..452
FT                   /note="Protein FAM222A"
FT                   /id="PRO_0000274239"
FT   CONFLICT        85
FT                   /note="S -> G (in Ref. 1; BAB55244)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        347
FT                   /note="A -> V (in Ref. 1; BAC11219)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        360
FT                   /note="C -> Y (in Ref. 1; BAB55244)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   452 AA;  46792 MW;  2CD0D013C638E3D5 CRC64;
     MLACLQRTQN APGQHLACPS KSLELRKCEA VASAMHSSRY PSPAELDAYA EKVANSPLSI
     KIFPTNIRVP QHKHLSRTVN GYDTSGQRYS PYPQHTAGYQ GLLAIVKAAV SSSSTAAPAG
     PAKSVLKSAE GKRTKLSPAA VQVGIAPYPV PSTLGPLAYP KPPEAPAPPP GLPAAATAAS
     VIPLPGRGLP LPPSNLPSIH SLLYQLNQQC QAPGAAPPAC QGMAIPHPSP AKHGPVPSFP
     SMAYSAAAGL PDCRKGTELG QGATQALTLA GAAKPAGYAD SGLDYLLWPQ KPPPPPPQPL
     RAYSGSTVAS KSPEACGGRA YERASGSPLN CGVGLPTSFT VGQYFAAPWN SVLVTPTSDC
     YNPAAAVVVT ELGPGAAREL AGPPADALSG LPSKSVCNTS VLSSSLQSLE YLINDIRPPC
     IKEQMLGKGY ETVAVPRLLD HQHAHIRLPV YR
 
 
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