F222B_HUMAN
ID F222B_HUMAN Reviewed; 562 AA.
AC Q8WU58; Q9H6F3; Q9NVJ4; Q9NXN6;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein FAM222B;
GN Name=FAM222B; Synonyms=C17orf63;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, Kidney epithelium, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8WU58; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-2807642, EBI-357530;
CC Q8WU58; Q9NXR5-2: ANKRD10; NbExp=3; IntAct=EBI-2807642, EBI-12102070;
CC Q8WU58; O95429: BAG4; NbExp=3; IntAct=EBI-2807642, EBI-2949658;
CC Q8WU58; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-2807642, EBI-11524452;
CC Q8WU58; Q9NP55: BPIFA1; NbExp=3; IntAct=EBI-2807642, EBI-953896;
CC Q8WU58; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-2807642, EBI-12809220;
CC Q8WU58; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-2807642, EBI-11976299;
CC Q8WU58; Q9BXL8: CDCA4; NbExp=3; IntAct=EBI-2807642, EBI-1773949;
CC Q8WU58; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-2807642, EBI-12819063;
CC Q8WU58; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-2807642, EBI-3867333;
CC Q8WU58; O00303: EIF3F; NbExp=3; IntAct=EBI-2807642, EBI-711990;
CC Q8WU58; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-2807642, EBI-12193763;
CC Q8WU58; Q13643: FHL3; NbExp=3; IntAct=EBI-2807642, EBI-741101;
CC Q8WU58; P53539: FOSB; NbExp=3; IntAct=EBI-2807642, EBI-2806743;
CC Q8WU58; Q5TA45: INTS11; NbExp=3; IntAct=EBI-2807642, EBI-748258;
CC Q8WU58; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-2807642, EBI-1052037;
CC Q8WU58; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-2807642, EBI-3957672;
CC Q8WU58; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-2807642, EBI-9996449;
CC Q8WU58; Q9BV99: LRRC61; NbExp=3; IntAct=EBI-2807642, EBI-2350424;
CC Q8WU58; O43482: OIP5; NbExp=3; IntAct=EBI-2807642, EBI-536879;
CC Q8WU58; P50479: PDLIM4; NbExp=3; IntAct=EBI-2807642, EBI-372861;
CC Q8WU58; Q99471: PFDN5; NbExp=3; IntAct=EBI-2807642, EBI-357275;
CC Q8WU58; O15496: PLA2G10; NbExp=3; IntAct=EBI-2807642, EBI-726466;
CC Q8WU58; P86480: PRR20D; NbExp=3; IntAct=EBI-2807642, EBI-12754095;
CC Q8WU58; Q01196-8: RUNX1; NbExp=3; IntAct=EBI-2807642, EBI-12001422;
CC Q8WU58; Q53HV7-2: SMUG1; NbExp=3; IntAct=EBI-2807642, EBI-12275818;
CC Q8WU58; Q5JUK2: SOHLH1; NbExp=3; IntAct=EBI-2807642, EBI-12288855;
CC Q8WU58; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-2807642, EBI-11959123;
CC Q8WU58; Q15654: TRIP6; NbExp=3; IntAct=EBI-2807642, EBI-742327;
CC Q8WU58; Q86WV8: TSC1; NbExp=3; IntAct=EBI-2807642, EBI-12806590;
CC Q8WU58; Q14166: TTLL12; NbExp=3; IntAct=EBI-2807642, EBI-923010;
CC Q8WU58; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-2807642, EBI-947187;
CC Q8WU58; Q6NVU6: UFSP1; NbExp=3; IntAct=EBI-2807642, EBI-12068150;
CC Q8WU58; Q9NZC7-5: WWOX; NbExp=5; IntAct=EBI-2807642, EBI-12040603;
CC Q8WU58; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-2807642, EBI-12030590;
CC Q8WU58; G4XUV3; NbExp=3; IntAct=EBI-2807642, EBI-10177989;
CC -!- SIMILARITY: Belongs to the FAM222 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA90974.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB15306.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK000147; BAA90974.1; ALT_FRAME; mRNA.
DR EMBL; AK001562; BAA91757.1; -; mRNA.
DR EMBL; AK025980; BAB15306.1; ALT_INIT; mRNA.
DR EMBL; AC010761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC024267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC021228; AAH21228.1; -; mRNA.
DR CCDS; CCDS45637.1; -.
DR RefSeq; NP_001070966.1; NM_001077498.2.
DR RefSeq; NP_001275560.1; NM_001288631.1.
DR RefSeq; NP_001275561.1; NM_001288632.1.
DR RefSeq; NP_001275562.1; NM_001288633.1.
DR RefSeq; NP_001275563.1; NM_001288634.1.
DR RefSeq; NP_001275564.1; NM_001288635.1.
DR RefSeq; NP_001275565.1; NM_001288636.1.
DR RefSeq; NP_001275566.1; NM_001288637.1.
DR RefSeq; NP_001275567.1; NM_001288638.1.
DR RefSeq; NP_001275568.1; NM_001288639.1.
DR RefSeq; NP_001275569.1; NM_001288640.1.
DR RefSeq; NP_060652.2; NM_018182.3.
DR RefSeq; XP_016880320.1; XM_017024831.1.
DR RefSeq; XP_016880321.1; XM_017024832.1.
DR RefSeq; XP_016880322.1; XM_017024833.1.
DR RefSeq; XP_016880323.1; XM_017024834.1.
DR AlphaFoldDB; Q8WU58; -.
DR BioGRID; 120850; 39.
DR IntAct; Q8WU58; 40.
DR STRING; 9606.ENSP00000462419; -.
DR GlyGen; Q8WU58; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8WU58; -.
DR PhosphoSitePlus; Q8WU58; -.
DR BioMuta; FAM222B; -.
DR DMDM; 74730670; -.
DR EPD; Q8WU58; -.
DR MassIVE; Q8WU58; -.
DR PaxDb; Q8WU58; -.
DR PeptideAtlas; Q8WU58; -.
DR PRIDE; Q8WU58; -.
DR ProteomicsDB; 74633; -.
DR Antibodypedia; 63797; 52 antibodies from 12 providers.
DR DNASU; 55731; -.
DR Ensembl; ENST00000452648.8; ENSP00000413645.3; ENSG00000173065.14.
DR Ensembl; ENST00000577376.6; ENSP00000464355.2; ENSG00000173065.14.
DR Ensembl; ENST00000577513.6; ENSP00000463642.2; ENSG00000173065.14.
DR Ensembl; ENST00000581229.6; ENSP00000464299.2; ENSG00000173065.14.
DR Ensembl; ENST00000581407.6; ENSP00000462419.1; ENSG00000173065.14.
DR Ensembl; ENST00000583307.6; ENSP00000463296.2; ENSG00000173065.14.
DR GeneID; 55731; -.
DR KEGG; hsa:55731; -.
DR MANE-Select; ENST00000581407.6; ENSP00000462419.1; NM_001077498.3; NP_001070966.1.
DR UCSC; uc002hct.2; human.
DR CTD; 55731; -.
DR DisGeNET; 55731; -.
DR GeneCards; FAM222B; -.
DR HGNC; HGNC:25563; FAM222B.
DR HPA; ENSG00000173065; Low tissue specificity.
DR neXtProt; NX_Q8WU58; -.
DR OpenTargets; ENSG00000173065; -.
DR PharmGKB; PA142672246; -.
DR VEuPathDB; HostDB:ENSG00000173065; -.
DR eggNOG; ENOG502QQED; Eukaryota.
DR GeneTree; ENSGT00530000063811; -.
DR HOGENOM; CLU_027495_0_0_1; -.
DR InParanoid; Q8WU58; -.
DR OMA; HPANTLL; -.
DR OrthoDB; 379104at2759; -.
DR PhylomeDB; Q8WU58; -.
DR TreeFam; TF331508; -.
DR PathwayCommons; Q8WU58; -.
DR SignaLink; Q8WU58; -.
DR BioGRID-ORCS; 55731; 12 hits in 1081 CRISPR screens.
DR ChiTaRS; FAM222B; human.
DR GenomeRNAi; 55731; -.
DR Pharos; Q8WU58; Tdark.
DR PRO; PR:Q8WU58; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8WU58; protein.
DR Bgee; ENSG00000173065; Expressed in sperm and 209 other tissues.
DR ExpressionAtlas; Q8WU58; baseline and differential.
DR Genevisible; Q8WU58; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR029340; FAM222.
DR PANTHER; PTHR16070; PTHR16070; 1.
DR Pfam; PF15258; FAM222A; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..562
FT /note="Protein FAM222B"
FT /id="PRO_0000274245"
FT REGION 155..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 471
FT /note="L -> S (in dbSNP:rs2043031)"
FT /id="VAR_050900"
FT VARIANT 542
FT /note="G -> S (in dbSNP:rs36029715)"
FT /id="VAR_050901"
FT CONFLICT 15
FT /note="L -> P (in Ref. 1; BAA91757)"
FT /evidence="ECO:0000305"
FT CONFLICT 261
FT /note="Q -> R (in Ref. 1; BAA91757)"
FT /evidence="ECO:0000305"
FT CONFLICT 557
FT /note="Q -> L (in Ref. 1; BAA91757)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 562 AA; 59652 MW; 5DCE56EBA36523C3 CRC64;
MLACLPGPGD LSFQLLSHTQ MNTGLQKWDT TQKMRTAHYP TPAELDAYAK KVANNPLTIK
IFPNSVKVPQ RKHVRRTVNG LDTSAQRYSP YPTQAATKAG LLAIVKVPAK SILKDFDGTR
ARLLPEAIMN PPVAPYATVA PSTLAHPQAQ ALARQQALQH AQTLAHAPPQ TLQHPQGIPP
PQALSHPQSL QQPQGLGHPQ PMAQTQGLVH PQALAHQGLQ HPHNPLLHGG RKMPDSDAPP
NVTVSTSTIP LSMAATLQHS QPPDLSSIVH QINQFCQTRA GISTTSVCEG QIANPSPISR
SLLINASTRV STHSVPTPMP SCVVNPMEHT HAATAALPAA GPVNLPTGIS RVPTGYPSDL
KPVTWNQHQL AHLQQMCSEA SGTPAPGLTG KHAAGRELAG PGFVGKAPAY PQELCLAQSF
HLKPPLEKPT PSPPVNGMAA PLAYPNGHYF QPLWNNILPT PNSDSSGSQD LAMPFHGGQP
TGAPLDCAAA PGAHYRAGTG GGPVASQNSL MQTVDYLSGD FQQACFREQS LAMLSKAHRA
PGNRAPDPTE SRSLHIQHPG YR
