F222B_MOUSE
ID F222B_MOUSE Reviewed; 562 AA.
AC Q6P539; Q3UV50; Q8VD11;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein FAM222B;
GN Name=Fam222b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone, and Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the FAM222 family. {ECO:0000305}.
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DR EMBL; AK137590; BAE23423.1; -; mRNA.
DR EMBL; AK141119; BAE24565.1; -; mRNA.
DR EMBL; AL591070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017647; AAH17647.1; -; mRNA.
DR EMBL; BC063099; AAH63099.1; -; mRNA.
DR CCDS; CCDS25089.1; -.
DR RefSeq; NP_663405.1; NM_145430.2.
DR RefSeq; XP_006533024.1; XM_006532961.3.
DR AlphaFoldDB; Q6P539; -.
DR STRING; 10090.ENSMUSP00000121832; -.
DR iPTMnet; Q6P539; -.
DR PhosphoSitePlus; Q6P539; -.
DR MaxQB; Q6P539; -.
DR PaxDb; Q6P539; -.
DR PRIDE; Q6P539; -.
DR ProteomicsDB; 271539; -.
DR Antibodypedia; 63797; 52 antibodies from 12 providers.
DR Ensembl; ENSMUST00000073705; ENSMUSP00000073384; ENSMUSG00000037750.
DR Ensembl; ENSMUST00000155571; ENSMUSP00000121832; ENSMUSG00000037750.
DR GeneID; 216971; -.
DR KEGG; mmu:216971; -.
DR UCSC; uc007kic.2; mouse.
DR CTD; 55731; -.
DR MGI; MGI:2384939; Fam222b.
DR VEuPathDB; HostDB:ENSMUSG00000037750; -.
DR eggNOG; ENOG502QQED; Eukaryota.
DR GeneTree; ENSGT00530000063811; -.
DR HOGENOM; CLU_027495_0_0_1; -.
DR InParanoid; Q6P539; -.
DR OMA; HPANTLL; -.
DR OrthoDB; 379104at2759; -.
DR PhylomeDB; Q6P539; -.
DR TreeFam; TF331508; -.
DR BioGRID-ORCS; 216971; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Fam222b; mouse.
DR PRO; PR:Q6P539; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q6P539; protein.
DR Bgee; ENSMUSG00000037750; Expressed in animal zygote and 212 other tissues.
DR ExpressionAtlas; Q6P539; baseline and differential.
DR Genevisible; Q6P539; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR029340; FAM222.
DR PANTHER; PTHR16070; PTHR16070; 1.
DR Pfam; PF15258; FAM222A; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..562
FT /note="Protein FAM222B"
FT /id="PRO_0000274246"
FT REGION 147..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 155
FT /note="Q -> L (in Ref. 3; AAH63099)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 562 AA; 59616 MW; 043956BCE38CFD6B CRC64;
MLACLPGPGD LSLQLLSHTQ MNTGLQKWDT TQKMRTAHYP TPAELDAYAK KVANNPLTIK
IFPNSVKVPQ RKHVRRTVNG LDTSAQRYSP YPTQAATKAG LLAIVKVPAK SILKDFDGTR
ARFLPEAIMN PPVAPYATVA PSTLAHPQAQ ALARQQALQH AQTLAHAPPQ TLQHPQGIPP
PQALSHPQSL QQPQGLGHPQ QMAQTQGLVH PQALTHQGLQ HPPNPLLHGG RKMPDSDAPP
NVTVSTSTIP LSMAATLQHS QPPDLSSIVH QINQFCQTRA GISTTSVCEG QIANPSPISR
SLLINASTRV STHSVPTPMP SCVVNPMEHT HAATAALPAA GPVNLPTGIS RAPTGYPSDL
KPVTWNQHQL AHLQQMCSEA GGTPAPGLTG KHTAGRELAG PGFVGKAAAY PQELCLAQSF
HLKPPLEKPT PSPPVNGLPA PLAYPNGHYF QPLWNNILPT PNSDSSGSQD LTMPFHGGQP
TGAPLDCGAA PGAHYRAGTG GGPVASQNSL MQTVDYLSGD FQQACFREQS LAMLSKAHRA
PGTRAPDPTD SRSLHIQHPG YR
