F227B_HUMAN
ID F227B_HUMAN Reviewed; 508 AA.
AC Q96M60; Q86WS2;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein FAM227B;
GN Name=FAM227B; Synonyms=C15orf33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96M60-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96M60-2; Sequence=VSP_019517, VSP_019518;
CC -!- SIMILARITY: Belongs to the FAM227 family. {ECO:0000305}.
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DR EMBL; AK057362; BAB71451.1; -; mRNA.
DR EMBL; AC018927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC022306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC025919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC048125; AAH48125.1; -; mRNA.
DR CCDS; CCDS32237.1; -. [Q96M60-1]
DR CCDS; CCDS81880.1; -. [Q96M60-2]
DR RefSeq; NP_001317222.1; NM_001330293.1. [Q96M60-2]
DR RefSeq; NP_689860.2; NM_152647.2. [Q96M60-1]
DR RefSeq; XP_006720487.1; XM_006720424.2. [Q96M60-1]
DR AlphaFoldDB; Q96M60; -.
DR SMR; Q96M60; -.
DR BioGRID; 128231; 15.
DR STRING; 9606.ENSP00000299338; -.
DR iPTMnet; Q96M60; -.
DR PhosphoSitePlus; Q96M60; -.
DR BioMuta; FAM227B; -.
DR DMDM; 109822386; -.
DR MassIVE; Q96M60; -.
DR PaxDb; Q96M60; -.
DR PeptideAtlas; Q96M60; -.
DR PRIDE; Q96M60; -.
DR ProteomicsDB; 77297; -. [Q96M60-1]
DR ProteomicsDB; 77298; -. [Q96M60-2]
DR Antibodypedia; 53018; 22 antibodies from 10 providers.
DR DNASU; 196951; -.
DR Ensembl; ENST00000299338.11; ENSP00000299338.6; ENSG00000166262.16. [Q96M60-1]
DR Ensembl; ENST00000561064.5; ENSP00000453028.1; ENSG00000166262.16. [Q96M60-2]
DR GeneID; 196951; -.
DR KEGG; hsa:196951; -.
DR MANE-Select; ENST00000299338.11; ENSP00000299338.6; NM_152647.3; NP_689860.2.
DR UCSC; uc001zxl.3; human. [Q96M60-1]
DR CTD; 196951; -.
DR DisGeNET; 196951; -.
DR GeneCards; FAM227B; -.
DR HGNC; HGNC:26543; FAM227B.
DR HPA; ENSG00000166262; Low tissue specificity.
DR neXtProt; NX_Q96M60; -.
DR OpenTargets; ENSG00000166262; -.
DR PharmGKB; PA142672269; -.
DR VEuPathDB; HostDB:ENSG00000166262; -.
DR eggNOG; ENOG502RXR1; Eukaryota.
DR GeneTree; ENSGT00940000162699; -.
DR HOGENOM; CLU_028274_0_0_1; -.
DR InParanoid; Q96M60; -.
DR OMA; RQFARNQ; -.
DR OrthoDB; 1153514at2759; -.
DR PhylomeDB; Q96M60; -.
DR TreeFam; TF328873; -.
DR PathwayCommons; Q96M60; -.
DR SignaLink; Q96M60; -.
DR BioGRID-ORCS; 196951; 5 hits in 1067 CRISPR screens.
DR ChiTaRS; FAM227B; human.
DR GenomeRNAi; 196951; -.
DR Pharos; Q96M60; Tdark.
DR PRO; PR:Q96M60; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q96M60; protein.
DR Bgee; ENSG00000166262; Expressed in buccal mucosa cell and 102 other tissues.
DR ExpressionAtlas; Q96M60; baseline and differential.
DR Genevisible; Q96M60; HS.
DR InterPro; IPR029417; FAM227.
DR PANTHER; PTHR33560; PTHR33560; 1.
DR Pfam; PF14922; FWWh; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..508
FT /note="Protein FAM227B"
FT /id="PRO_0000244098"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 216..249
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019517"
FT VAR_SEQ 339..508
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019518"
FT CONFLICT 57
FT /note="I -> M (in Ref. 1; BAB71451)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 508 AA; 59956 MW; 18942FDCB86CCBB0 CRC64;
MAGQRTCQRR SSRAGPGKMQ EPPKSIEEFL KFQNWDYWPR EIHFRDDDKW SCTLKKIKED
SSFVSIYTHL WENVPRIFEA LLIMESKLKE YSLILQNHTS EIFKWKSMIS ETSSYRKLER
YGEFLKKYHK KKKIMLSDEM ETEKNIEGCS FTGFKANELT QLPRHLDAEQ IYLFILKAHN
FDERVFKIWK THFLSEASIA LLHDSFWWWF LHKFRPDREN QDCLFDRISE SYVTLFMSIP
LSRKDAFFQI YPDCLAQAIY ATFHEAFPES SYLFNDEFKE DLGNNIFLWC SGLKPQKGFW
IHWKLKELST TTIHGSKKAP AKSVKERIAD SQEHISTSID FNIIKILNNP RAYTLPISKE
ESRLSRLATK SHYSSTGPEF NRVLFNFGGQ SPLILYYLKM HELAGISKAP KKTKIKLTKI
FQEPLPAPTY RDVIKEAKRQ FARNQKDFRI LQAKATKKPH EVKQDFEKFL HKLRSEAEIE
RECVASLSSS SSSSPSSTDN YNFEEEEY
