F227B_MOUSE
ID F227B_MOUSE Reviewed; 532 AA.
AC Q9D518; A2AR82;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 3.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Protein FAM227B;
GN Name=Fam227b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-393.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SIMILARITY: Belongs to the FAM227 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB30022.1; Type=Miscellaneous discrepancy; Note=Intron retention. The sequence differs at its 3' end due to intron retention.; Evidence={ECO:0000305};
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DR EMBL; AL845292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK015893; BAB30022.1; ALT_SEQ; mRNA.
DR CCDS; CCDS50697.1; -.
DR RefSeq; NP_083731.2; NM_029455.3.
DR AlphaFoldDB; Q9D518; -.
DR SMR; Q9D518; -.
DR IntAct; Q9D518; 2.
DR MINT; Q9D518; -.
DR STRING; 10090.ENSMUSP00000106076; -.
DR PaxDb; Q9D518; -.
DR PRIDE; Q9D518; -.
DR ProteomicsDB; 277022; -.
DR Antibodypedia; 53018; 22 antibodies from 10 providers.
DR Ensembl; ENSMUST00000110446; ENSMUSP00000106076; ENSMUSG00000027209.
DR Ensembl; ENSMUST00000178118; ENSMUSP00000136349; ENSMUSG00000027209.
DR GeneID; 75823; -.
DR KEGG; mmu:75823; -.
DR UCSC; uc012cde.2; mouse.
DR CTD; 196951; -.
DR MGI; MGI:1923073; Fam227b.
DR VEuPathDB; HostDB:ENSMUSG00000027209; -.
DR eggNOG; ENOG502RXR1; Eukaryota.
DR GeneTree; ENSGT00940000162699; -.
DR HOGENOM; CLU_028274_0_0_1; -.
DR InParanoid; Q9D518; -.
DR OrthoDB; 1153514at2759; -.
DR PhylomeDB; Q9D518; -.
DR TreeFam; TF328873; -.
DR BioGRID-ORCS; 75823; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q9D518; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D518; protein.
DR Bgee; ENSMUSG00000027209; Expressed in spermatid and 79 other tissues.
DR ExpressionAtlas; Q9D518; baseline and differential.
DR Genevisible; Q9D518; MM.
DR InterPro; IPR029417; FAM227.
DR PANTHER; PTHR33560; PTHR33560; 1.
DR Pfam; PF14922; FWWh; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..532
FT /note="Protein FAM227B"
FT /id="PRO_0000244100"
FT REGION 494..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 432..482
FT /evidence="ECO:0000255"
FT COMPBIAS 499..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 151
FT /note="L -> F (in Ref. 2; BAB30022)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 532 AA; 62785 MW; FF711722AD875ED3 CRC64;
MELPVPQKLP DPPRSFDEFL KSQNWDYWPR DVHFRDSDIW EDTLKKLEEA ISYTSIYSYL
WTNVPRLYDI VDSLESKLKE SSHLLQHHAS RLFESDKMIS KKRSYTNLER YKAFVKEHYR
PKKIALSDRM ETEKNIEGCT FLFNQNEVTQ LPRHLDAKQI YLYVLKTHNF EEKVFKVWKT
HVLSDCSIAL LHDSFWWWFL HKFKPDKRDE DFLFDRIAES YVTLFIKIPL RRKDAFFKMY
PDCLTQAVYT TFQESFPESC SLFNDKFKED LGNTIFLWLS GLKPETGFWT HWKLQDLCTT
TIHGSRRVPV KLRRSVIPSQ EHIPGIRDLK IEDILKNPRA YAMPKLMKES VASKAATKPS
HYRSLGPEFH KVLFDFGGQS PLILYYLKMH ELGGISVTHN PKGTKFTKIL REPSPAPTYC
DIIRDAKRKF ADNKKDFKRV KQRIKDDIKF LREQQELIDK ELDRIQAKAS KNLQEVKNEF
ENFLHKQRVE AKLKEEYGGS TSASESPQSM QSPQSSSSFP TISEDFNNVE EG
