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F228A_HUMAN
ID   F228A_HUMAN             Reviewed;         206 AA.
AC   Q86W67;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Protein FAM228A;
GN   Name=FAM228A; Synonyms=C2orf84;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q86W67; Q13895: BYSL; NbExp=3; IntAct=EBI-12958227, EBI-358049;
CC       Q86W67; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-12958227, EBI-10961624;
CC       Q86W67; P55273: CDKN2D; NbExp=3; IntAct=EBI-12958227, EBI-745859;
CC       Q86W67; P10606: COX5B; NbExp=3; IntAct=EBI-12958227, EBI-1053725;
CC       Q86W67; Q96JC9: EAF1; NbExp=3; IntAct=EBI-12958227, EBI-769261;
CC       Q86W67; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-12958227, EBI-744099;
CC       Q86W67; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-12958227, EBI-6658203;
CC       Q86W67; P13807: GYS1; NbExp=3; IntAct=EBI-12958227, EBI-740553;
CC       Q86W67; O75031: HSF2BP; NbExp=3; IntAct=EBI-12958227, EBI-7116203;
CC       Q86W67; P25791-3: LMO2; NbExp=3; IntAct=EBI-12958227, EBI-11959475;
CC       Q86W67; P61968: LMO4; NbExp=3; IntAct=EBI-12958227, EBI-2798728;
CC       Q86W67; P40692: MLH1; NbExp=3; IntAct=EBI-12958227, EBI-744248;
CC       Q86W67; Q6IQ23-2: PLEKHA7; NbExp=3; IntAct=EBI-12958227, EBI-12069346;
CC       Q86W67; P21673: SAT1; NbExp=3; IntAct=EBI-12958227, EBI-711613;
CC       Q86W67; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-12958227, EBI-748391;
CC       Q86W67; Q5MJ09: SPANXN3; NbExp=3; IntAct=EBI-12958227, EBI-12037215;
CC       Q86W67; Q63HR2: TNS2; NbExp=3; IntAct=EBI-12958227, EBI-949753;
CC       Q86W67; P36508: ZNF76; NbExp=3; IntAct=EBI-12958227, EBI-7254550;
CC   -!- SIMILARITY: Belongs to the FAM228 family. {ECO:0000305}.
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DR   EMBL; AC008073; AAY14667.1; -; Genomic_DNA.
DR   EMBL; CH471053; EAX00756.1; -; Genomic_DNA.
DR   EMBL; BC050462; AAH50462.1; -; mRNA.
DR   CCDS; CCDS42659.1; -.
DR   RefSeq; NP_001035800.1; NM_001040710.2.
DR   AlphaFoldDB; Q86W67; -.
DR   BioGRID; 575555; 19.
DR   IntAct; Q86W67; 19.
DR   STRING; 9606.ENSP00000295150; -.
DR   iPTMnet; Q86W67; -.
DR   PhosphoSitePlus; Q86W67; -.
DR   BioMuta; FAM228A; -.
DR   EPD; Q86W67; -.
DR   MassIVE; Q86W67; -.
DR   PaxDb; Q86W67; -.
DR   PeptideAtlas; Q86W67; -.
DR   PRIDE; Q86W67; -.
DR   Antibodypedia; 51135; 9 antibodies from 5 providers.
DR   DNASU; 653140; -.
DR   Ensembl; ENST00000295150.8; ENSP00000295150.3; ENSG00000186453.13.
DR   GeneID; 653140; -.
DR   KEGG; hsa:653140; -.
DR   MANE-Select; ENST00000295150.8; ENSP00000295150.3; NM_001040710.3; NP_001035800.1.
DR   UCSC; uc002rfc.3; human.
DR   CTD; 653140; -.
DR   DisGeNET; 653140; -.
DR   GeneCards; FAM228A; -.
DR   HGNC; HGNC:34418; FAM228A.
DR   HPA; ENSG00000186453; Tissue enriched (testis).
DR   neXtProt; NX_Q86W67; -.
DR   OpenTargets; ENSG00000186453; -.
DR   PharmGKB; PA164717160; -.
DR   VEuPathDB; HostDB:ENSG00000186453; -.
DR   eggNOG; ENOG502TDFN; Eukaryota.
DR   GeneTree; ENSGT00530000064185; -.
DR   InParanoid; Q86W67; -.
DR   OMA; HEQHILV; -.
DR   OrthoDB; 1180736at2759; -.
DR   PhylomeDB; Q86W67; -.
DR   TreeFam; TF336288; -.
DR   PathwayCommons; Q86W67; -.
DR   SignaLink; Q86W67; -.
DR   BioGRID-ORCS; 653140; 12 hits in 1061 CRISPR screens.
DR   GenomeRNAi; 653140; -.
DR   Pharos; Q86W67; Tdark.
DR   PRO; PR:Q86W67; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q86W67; protein.
DR   Bgee; ENSG00000186453; Expressed in left testis and 97 other tissues.
DR   ExpressionAtlas; Q86W67; baseline and differential.
DR   Genevisible; Q86W67; HS.
DR   InterPro; IPR040046; FAM228.
DR   PANTHER; PTHR28584; PTHR28584; 2.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..206
FT                   /note="Protein FAM228A"
FT                   /id="PRO_0000348445"
FT   VARIANT         140
FT                   /note="Y -> C (in dbSNP:rs2288073)"
FT                   /id="VAR_046178"
SQ   SEQUENCE   206 AA;  23752 MW;  DC057FFD707AA688 CRC64;
     MAATKTASYD EHFRPEKLRE WPEPESVSLM EVLAREDIDE AVCAILFKEN SIVKVTVPPF
     VDPLFQRQQE VDEERRTGLQ CETGKRHSIK ELEEIEKARL HASSPYFTFT SHCVIPKEWH
     KASARARSKT YKYSPEKLIY ADKKQKRKEK KTADLSQAAF ERQFLSSKLS QKNKVGERKG
     LVSRGLGRGW HAGLCSTHEQ HILVPE
 
 
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