F228A_MOUSE
ID F228A_MOUSE Reviewed; 299 AA.
AC Q8CDW1; Q9D5M5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Protein FAM228A;
GN Name=Fam228a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CDW1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CDW1-2; Sequence=VSP_035162, VSP_035163;
CC -!- SIMILARITY: Belongs to the FAM228 family. {ECO:0000305}.
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DR EMBL; AK015158; BAB29728.1; -; mRNA.
DR EMBL; AK029492; BAC26475.1; -; mRNA.
DR EMBL; CH466623; EDL01360.1; -; Genomic_DNA.
DR EMBL; BC138846; AAI38847.1; -; mRNA.
DR EMBL; BC138853; AAI38854.1; -; mRNA.
DR CCDS; CCDS49018.1; -. [Q8CDW1-1]
DR RefSeq; NP_083383.1; NM_029107.2. [Q8CDW1-1]
DR RefSeq; XP_017170714.1; XM_017315225.1.
DR AlphaFoldDB; Q8CDW1; -.
DR SMR; Q8CDW1; -.
DR iPTMnet; Q8CDW1; -.
DR PhosphoSitePlus; Q8CDW1; -.
DR PaxDb; Q8CDW1; -.
DR PRIDE; Q8CDW1; -.
DR Antibodypedia; 51135; 9 antibodies from 5 providers.
DR DNASU; 74855; -.
DR Ensembl; ENSMUST00000111154; ENSMUSP00000106784; ENSMUSG00000079177. [Q8CDW1-1]
DR Ensembl; ENSMUST00000222363; ENSMUSP00000152506; ENSMUSG00000079177. [Q8CDW1-1]
DR GeneID; 74855; -.
DR KEGG; mmu:74855; -.
DR UCSC; uc007myb.1; mouse. [Q8CDW1-1]
DR UCSC; uc007myc.1; mouse. [Q8CDW1-2]
DR CTD; 653140; -.
DR MGI; MGI:1922105; Fam228a.
DR VEuPathDB; HostDB:ENSMUSG00000079177; -.
DR eggNOG; ENOG502RU0D; Eukaryota.
DR GeneTree; ENSGT00530000064185; -.
DR HOGENOM; CLU_079089_0_0_1; -.
DR InParanoid; Q8CDW1; -.
DR OMA; QHRPRSW; -.
DR OrthoDB; 1180736at2759; -.
DR PhylomeDB; Q8CDW1; -.
DR TreeFam; TF336288; -.
DR BioGRID-ORCS; 74855; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Fam228a; mouse.
DR PRO; PR:Q8CDW1; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8CDW1; protein.
DR Bgee; ENSMUSG00000079177; Expressed in spermatocyte and 27 other tissues.
DR ExpressionAtlas; Q8CDW1; baseline and differential.
DR InterPro; IPR040046; FAM228.
DR PANTHER; PTHR28584; PTHR28584; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..299
FT /note="Protein FAM228A"
FT /id="PRO_0000348446"
FT REGION 135..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 264
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XIN5"
FT VAR_SEQ 146..172
FT /note="KTHDTQKEAKETEKGLSFTPFSLRPHC -> ALQPTRGCIEDTAKCQIVPPQ
FT EPQTCF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035162"
FT VAR_SEQ 173..299
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035163"
SQ SEQUENCE 299 AA; 34457 MW; F7986A6A29A62173 CRC64;
MADTKTSKCD EHFSVEKLKE WPEPESVSLM ELLAREDIDE AVHAVLFREN YVVKRLDTYL
QHLAVFKERR KEMLHKKWVE NVVQPLQQRI TDKITSYRRP GKNQVKYEHC LKQTNKPTKV
SSSCLFQKQQ EFREAKGTSY QHGRGKTHDT QKEAKETEKG LSFTPFSLRP HCSSPRERQR
ASARLMQSKP GGRNRYKGAS SEKPVFTLKS HLPKEEKTVS RSQLVFERQF RASRLSQDIK
EAEKKGLVVG TGPQRPRSWA AADSVPRPSL VGRRVMTAEI LGEHLVSLHQ AARSGLQWP
