ID   F228B_HUMAN             Reviewed;         324 AA.
AC   P0C875; A0A087WZA1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 2.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Protein FAM228B;
GN   Name=FAM228B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-229.
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- SIMILARITY: Belongs to the FAM228 family. {ECO:0000305}.
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DR   EMBL; AC008073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471053; EAX00757.1; -; Genomic_DNA.
DR   EMBL; AK055413; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS74491.1; -.
DR   RefSeq; NP_001139182.1; NM_001145710.1.
DR   AlphaFoldDB; P0C875; -.
DR   STRING; 9606.ENSP00000482482; -.
DR   iPTMnet; P0C875; -.
DR   PhosphoSitePlus; P0C875; -.
DR   BioMuta; FAM228B; -.
DR   DMDM; 205830714; -.
DR   jPOST; P0C875; -.
DR   MassIVE; P0C875; -.
DR   PaxDb; P0C875; -.
DR   PeptideAtlas; P0C875; -.
DR   PRIDE; P0C875; -.
DR   Antibodypedia; 64511; 10 antibodies from 6 providers.
DR   DNASU; 375190; -.
DR   Ensembl; ENST00000611127.4; ENSP00000483011.1; ENSG00000219626.9.
DR   Ensembl; ENST00000615575.5; ENSP00000482482.1; ENSG00000219626.9.
DR   GeneID; 375190; -.
DR   KEGG; hsa:375190; -.
DR   MANE-Select; ENST00000615575.5; ENSP00000482482.1; NM_001145710.2; NP_001139182.1.
DR   UCSC; uc032ngu.2; human.
DR   CTD; 375190; -.
DR   DisGeNET; 375190; -.
DR   GeneCards; FAM228B; -.
DR   HGNC; HGNC:24736; FAM228B.
DR   HPA; ENSG00000219626; Low tissue specificity.
DR   neXtProt; NX_P0C875; -.
DR   OpenTargets; ENSG00000219626; -.
DR   VEuPathDB; HostDB:ENSG00000219626; -.
DR   eggNOG; ENOG502S14E; Eukaryota.
DR   GeneTree; ENSGT00530000064185; -.
DR   InParanoid; P0C875; -.
DR   OMA; CSYKKIK; -.
DR   OrthoDB; 1180736at2759; -.
DR   PhylomeDB; P0C875; -.
DR   PathwayCommons; P0C875; -.
DR   BioGRID-ORCS; 375190; 8 hits in 304 CRISPR screens.
DR   ChiTaRS; FAM228B; human.
DR   GenomeRNAi; 375190; -.
DR   Pharos; P0C875; Tdark.
DR   PRO; PR:P0C875; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; P0C875; protein.
DR   Bgee; ENSG00000219626; Expressed in calcaneal tendon and 176 other tissues.
DR   ExpressionAtlas; P0C875; baseline and differential.
DR   InterPro; IPR040046; FAM228.
DR   PANTHER; PTHR28584; PTHR28584; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..324
FT                   /note="Protein FAM228B"
FT                   /id="PRO_0000348449"
SQ   SEQUENCE   324 AA;  38070 MW;  37C00C30C1D9ACA4 CRC64;
     MKNVDSDDLV TGTLPKLKSS KEWLEPKPLC FMEVLAKEDT EAAIQSILYK ENSVIKELDK
     YLQHHAFLNA RRKEMLYKRW VDCVADPLQK KIIEKVCSHK KIKKRRQGEL DGFLKHVNKK
     GNAFIEHYDP KEYDPFYMSK KDPNFLKVTI PPFHDPLKKA QYDKDNEKRT LLQCETGKIY
     SIKEFKEVEK VQLHSRFPQI SNSRHFITPN EWLKLPTRYI ESEFCRRRRL KVKVNFNDCS
     FDLKPLARAP YLLESQEEEK TVIYKNKGSS FLEREPLCYQ EGNNPSAKEA ISEGYFSSLS
     LSQEREEDQD GSPSPRLGLL KLEL