F228B_MOUSE
ID F228B_MOUSE Reviewed; 232 AA.
AC Q497Q6; Q8BLM3; Q8BWN5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Protein FAM228B;
GN Name=Fam228b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q497Q6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q497Q6-2; Sequence=VSP_035165, VSP_035166;
CC -!- SIMILARITY: Belongs to the FAM228 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC34259.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK044133; BAC31793.1; -; mRNA.
DR EMBL; AK050447; BAC34259.1; ALT_FRAME; mRNA.
DR EMBL; BC100429; AAI00430.1; -; mRNA.
DR EMBL; BC145648; AAI45649.1; -; mRNA.
DR CCDS; CCDS36400.1; -. [Q497Q6-1]
DR RefSeq; NP_780640.2; NM_175431.4. [Q497Q6-1]
DR RefSeq; XP_017170498.1; XM_017315009.1.
DR AlphaFoldDB; Q497Q6; -.
DR SMR; Q497Q6; -.
DR STRING; 10090.ENSMUSP00000050881; -.
DR iPTMnet; Q497Q6; -.
DR PhosphoSitePlus; Q497Q6; -.
DR PaxDb; Q497Q6; -.
DR PRIDE; Q497Q6; -.
DR ProteomicsDB; 271833; -. [Q497Q6-1]
DR ProteomicsDB; 271834; -. [Q497Q6-2]
DR DNASU; 207921; -.
DR Ensembl; ENSMUST00000053458; ENSMUSP00000050881; ENSMUSG00000050545. [Q497Q6-1]
DR Ensembl; ENSMUST00000218575; ENSMUSP00000151270; ENSMUSG00000050545. [Q497Q6-2]
DR GeneID; 207921; -.
DR KEGG; mmu:207921; -.
DR UCSC; uc007myd.2; mouse. [Q497Q6-2]
DR UCSC; uc007mye.2; mouse. [Q497Q6-1]
DR CTD; 375190; -.
DR MGI; MGI:2442121; Fam228b.
DR VEuPathDB; HostDB:ENSMUSG00000050545; -.
DR eggNOG; ENOG502S14E; Eukaryota.
DR GeneTree; ENSGT00530000064185; -.
DR HOGENOM; CLU_067936_1_0_1; -.
DR InParanoid; Q497Q6; -.
DR OMA; CSYKKIK; -.
DR OrthoDB; 1180736at2759; -.
DR PhylomeDB; Q497Q6; -.
DR TreeFam; TF336288; -.
DR BioGRID-ORCS; 207921; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Fam228b; mouse.
DR PRO; PR:Q497Q6; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q497Q6; protein.
DR Bgee; ENSMUSG00000050545; Expressed in spermatid and 191 other tissues.
DR ExpressionAtlas; Q497Q6; baseline and differential.
DR InterPro; IPR040046; FAM228.
DR PANTHER; PTHR28584; PTHR28584; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..232
FT /note="Protein FAM228B"
FT /id="PRO_0000348450"
FT VAR_SEQ 181
FT /note="K -> T (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035165"
FT VAR_SEQ 182..232
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035166"
SQ SEQUENCE 232 AA; 27823 MW; 1C7AB557D80A7E82 CRC64;
MTTMKNRSQD DMVTGTLPKL KSSKEWLEPQ SLSFMEALAK EDTDAAVQSI LYRENYIMKE
LDKYLHHQDF LNTRRKEMLY KKWVERVADP LQKKIIEKVH SHKNIKKRRR QELDNFLKHS
NKKGNAFIEH YDPKEYDPFY MSKEDPNFLK VIMPPFRDPL KKAQYDQDDE KRTLLQCETG
KIYTMKEFKE IEKAQLHSRF PSISNSRQSM TPNGWLKVPM SYIESEFCKK SR
