ID   F229B_HUMAN             Reviewed;          80 AA.
AC   Q4G0N7; B8ZZ33;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Protein FAM229B;
GN   Name=FAM229B; Synonyms=C6orf225;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q4G0N7; Q9BXA7: TSSK1B; NbExp=4; IntAct=EBI-18340430, EBI-6423734;
CC       Q4G0N7; Q96PF2: TSSK2; NbExp=3; IntAct=EBI-18340430, EBI-852089;
CC   -!- SIMILARITY: Belongs to the FAM229 family. {ECO:0000305}.
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DR   EMBL; Z99289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW48271.1; -; Genomic_DNA.
DR   EMBL; BC044912; AAH44912.1; -; mRNA.
DR   CCDS; CCDS34513.1; -.
DR   RefSeq; NP_001028736.1; NM_001033564.2.
DR   RefSeq; XP_016866663.1; XM_017011174.1.
DR   RefSeq; XP_016866664.1; XM_017011175.1.
DR   AlphaFoldDB; Q4G0N7; -.
DR   BioGRID; 534803; 2.
DR   IntAct; Q4G0N7; 2.
DR   STRING; 9606.ENSP00000357645; -.
DR   iPTMnet; Q4G0N7; -.
DR   PhosphoSitePlus; Q4G0N7; -.
DR   BioMuta; FAM229B; -.
DR   MassIVE; Q4G0N7; -.
DR   PaxDb; Q4G0N7; -.
DR   PeptideAtlas; Q4G0N7; -.
DR   PRIDE; Q4G0N7; -.
DR   Antibodypedia; 50601; 34 antibodies from 6 providers.
DR   DNASU; 619208; -.
DR   Ensembl; ENST00000368656.7; ENSP00000357645.2; ENSG00000203778.8.
DR   Ensembl; ENST00000604268.1; ENSP00000474987.1; ENSG00000203778.8.
DR   GeneID; 619208; -.
DR   KEGG; hsa:619208; -.
DR   MANE-Select; ENST00000368656.7; ENSP00000357645.2; NM_001033564.3; NP_001028736.1.
DR   UCSC; uc003pvs.4; human.
DR   CTD; 619208; -.
DR   GeneCards; FAM229B; -.
DR   HGNC; HGNC:33858; FAM229B.
DR   HPA; ENSG00000203778; Tissue enriched (testis).
DR   neXtProt; NX_Q4G0N7; -.
DR   OpenTargets; ENSG00000203778; -.
DR   PharmGKB; PA162380460; -.
DR   VEuPathDB; HostDB:ENSG00000203778; -.
DR   eggNOG; ENOG502TEG8; Eukaryota.
DR   GeneTree; ENSGT00390000017996; -.
DR   HOGENOM; CLU_2589122_0_0_1; -.
DR   InParanoid; Q4G0N7; -.
DR   OMA; ACNGKET; -.
DR   OrthoDB; 1597346at2759; -.
DR   PhylomeDB; Q4G0N7; -.
DR   TreeFam; TF339579; -.
DR   PathwayCommons; Q4G0N7; -.
DR   SignaLink; Q4G0N7; -.
DR   BioGRID-ORCS; 619208; 16 hits in 1065 CRISPR screens.
DR   ChiTaRS; FAM229B; human.
DR   GenomeRNAi; 619208; -.
DR   Pharos; Q4G0N7; Tdark.
DR   PRO; PR:Q4G0N7; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q4G0N7; protein.
DR   Bgee; ENSG00000203778; Expressed in left testis and 166 other tissues.
DR   Genevisible; Q4G0N7; HS.
DR   InterPro; IPR028025; FAM229.
DR   PANTHER; PTHR35355; PTHR35355; 1.
DR   Pfam; PF14982; UPF0731; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..80
FT                   /note="Protein FAM229B"
FT                   /id="PRO_0000335816"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   80 AA;  8717 MW;  1502585C621FA388 CRC64;
     MPFQFGTQPR RFPVEGGDSS IELEPGLSSS AACNGKEMSP TRQLRRCPGS HCLTITDVPV
     TVYATTRKPP AQSSKEMHPK