F234A_MOUSE
ID F234A_MOUSE Reviewed; 555 AA.
AC Q8C0Z1; Q3TZ74;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Protein FAM234A;
DE AltName: Full=Protein ITFG3;
GN Name=Fam234a {ECO:0000312|MGI:MGI:2146854}; Synonyms=Itfg3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Dendritic cell, Head, and Inner ear;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-116; ASN-120 AND ASN-392.
RC TISSUE=Myoblast;
RX PubMed=19656770; DOI=10.1074/mcp.m900195-mcp200;
RA Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D.,
RA Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.;
RT "The mouse C2C12 myoblast cell surface N-linked glycoproteome:
RT identification, glycosite occupancy, and membrane orientation.";
RL Mol. Cell. Proteomics 8:2555-2569(2009).
RN [4]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-116; ASN-120 AND ASN-392.
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-linked
RT cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM234 family. {ECO:0000305}.
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DR EMBL; AK029427; BAC26447.1; -; mRNA.
DR EMBL; AK158049; BAE34336.1; -; mRNA.
DR EMBL; AK170646; BAE41933.1; -; mRNA.
DR EMBL; BC046457; AAH46457.1; -; mRNA.
DR CCDS; CCDS37512.1; -.
DR RefSeq; NP_001193264.1; NM_001206335.1.
DR RefSeq; NP_997100.1; NM_207217.4.
DR RefSeq; XP_006523453.1; XM_006523390.3.
DR RefSeq; XP_011244538.1; XM_011246236.2.
DR RefSeq; XP_011244539.1; XM_011246237.2.
DR AlphaFoldDB; Q8C0Z1; -.
DR STRING; 10090.ENSMUSP00000110639; -.
DR GlyConnect; 2629; 1 N-Linked glycan (1 site).
DR GlyGen; Q8C0Z1; 6 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q8C0Z1; -.
DR PhosphoSitePlus; Q8C0Z1; -.
DR EPD; Q8C0Z1; -.
DR jPOST; Q8C0Z1; -.
DR MaxQB; Q8C0Z1; -.
DR PaxDb; Q8C0Z1; -.
DR PeptideAtlas; Q8C0Z1; -.
DR PRIDE; Q8C0Z1; -.
DR ProteomicsDB; 267693; -.
DR Antibodypedia; 2603; 149 antibodies from 21 providers.
DR DNASU; 106581; -.
DR Ensembl; ENSMUST00000114988; ENSMUSP00000110639; ENSMUSG00000024187.
DR Ensembl; ENSMUST00000118487; ENSMUSP00000113418; ENSMUSG00000024187.
DR Ensembl; ENSMUST00000234175; ENSMUSP00000157032; ENSMUSG00000024187.
DR Ensembl; ENSMUST00000234262; ENSMUSP00000157155; ENSMUSG00000024187.
DR Ensembl; ENSMUST00000234554; ENSMUSP00000157362; ENSMUSG00000024187.
DR Ensembl; ENSMUST00000234687; ENSMUSP00000157219; ENSMUSG00000024187.
DR GeneID; 106581; -.
DR KEGG; mmu:106581; -.
DR UCSC; uc008bdv.2; mouse.
DR CTD; 83986; -.
DR MGI; MGI:2146854; Fam234a.
DR VEuPathDB; HostDB:ENSMUSG00000024187; -.
DR eggNOG; ENOG502R0CE; Eukaryota.
DR GeneTree; ENSGT00530000063694; -.
DR HOGENOM; CLU_036490_0_0_1; -.
DR InParanoid; Q8C0Z1; -.
DR OMA; FMFWGLM; -.
DR OrthoDB; 294858at2759; -.
DR PhylomeDB; Q8C0Z1; -.
DR TreeFam; TF327203; -.
DR BioGRID-ORCS; 106581; 4 hits in 41 CRISPR screens.
DR ChiTaRS; Fam234a; mouse.
DR PRO; PR:Q8C0Z1; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8C0Z1; protein.
DR Bgee; ENSMUSG00000024187; Expressed in interventricular septum and 226 other tissues.
DR ExpressionAtlas; Q8C0Z1; baseline and differential.
DR Genevisible; Q8C0Z1; MM.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR045232; FAM234.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR PANTHER; PTHR21419; PTHR21419; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..555
FT /note="Protein FAM234A"
FT /id="PRO_0000247994"
FT TOPO_DOM 1..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..555
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5M7W6"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973,
FT ECO:0000269|PubMed:19656770"
FT CARBOHYD 120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973,
FT ECO:0000269|PubMed:19656770"
FT CARBOHYD 317
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 392
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973,
FT ECO:0000269|PubMed:19656770"
FT CARBOHYD 476
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 182
FT /note="R -> G (in Ref. 1; BAE34336)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="L -> V (in Ref. 1; BAE34336)"
FT /evidence="ECO:0000305"
FT CONFLICT 514
FT /note="V -> A (in Ref. 1; BAE34336)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 555 AA; 60576 MW; 9A4716CF6F6C9DBD CRC64;
MMDNKDLEAE IHPLKNEDKK SQENPGNLPR NEDNLKSKPV PSRLSRCRTV AFFLSLFTCL
FVVFVLSFII PCPDRPSSQG TWKLDYNNAV MYDFLALGDI NKDKVQDVLF LYKNTNSSNN
LTRSCADEGF STPCAFVVAV SGANGSVLWE RPVAQDVALV KCAMPQTLDS DEVSSACIVV
GRAGSFVAVS FFTGETLWSH PSSFSGNVSI LSPLLQVPDI DGDGDGTPDL LILAQEGQEV
SGALYSGSTG YQIGHRGSLG VDGDGVALLH VTRTGAQYIL LPCASALCGF SVKSLYERIT
GRDGHFKEDP YWENMLNHSV HRRLLHRLGA VRYLMNIPGK AGQDLLLVTS EACVLLDGQD
LEPRWTLGEV QVLRKPILGH YKPDTLAVVI ENGTSIDRQI LLLDLSTGSI LWSQPLPSLP
GGPPSTSLMT ADHRSAFFFW GLHDLVSTNE MDPPDVQHSL YMFHPTLPGI LLELANVSAN
IVAFDAVLLE PSRHAAYVLL TGPASSDVPG LVSVTKHKVQ DLVPGSRVIH LGEGSSDSDQ
AIRDRFSRLR YRSEM
