F234B_HUMAN
ID F234B_HUMAN Reviewed; 622 AA.
AC A2RU67; Q49AF2; Q5CZ81; Q6ZUV7; Q9P261;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Protein FAM234B;
GN Name=FAM234B {ECO:0000312|HGNC:HGNC:29288}; Synonyms=KIAA1467;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-622.
RC TISSUE=Brain;
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-30; SER-33 AND
RP SER-62, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-33, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-26 AND SER-30, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}. Golgi outpost {ECO:0000250|UniProtKB:D3ZWJ9}.
CC Cytoplasm, cytoskeleton, microtubule organizing center
CC {ECO:0000250|UniProtKB:D3ZWJ9}. Note=Localizes to the postsynaptic
CC Golgi apparatus region, also named Golgi outpost, which shapes dendrite
CC morphology by functioning as sites of acentrosomal microtubule
CC nucleation. {ECO:0000250|UniProtKB:D3ZWJ9}.
CC -!- SIMILARITY: Belongs to the FAM234 family. {ECO:0000305}.
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DR EMBL; AK125278; BAC86111.1; -; mRNA.
DR EMBL; CR936647; CAI56785.1; -; mRNA.
DR EMBL; BC039267; AAH39267.1; -; mRNA.
DR EMBL; BC132772; AAI32773.1; -; mRNA.
DR EMBL; BC132774; AAI32775.1; -; mRNA.
DR EMBL; AB040900; BAA95991.1; -; mRNA.
DR CCDS; CCDS31750.1; -.
DR RefSeq; NP_065904.1; NM_020853.1.
DR AlphaFoldDB; A2RU67; -.
DR BioGRID; 121660; 74.
DR IntAct; A2RU67; 40.
DR STRING; 9606.ENSP00000197268; -.
DR GlyGen; A2RU67; 3 sites.
DR iPTMnet; A2RU67; -.
DR PhosphoSitePlus; A2RU67; -.
DR BioMuta; FAM234B; -.
DR EPD; A2RU67; -.
DR jPOST; A2RU67; -.
DR MassIVE; A2RU67; -.
DR MaxQB; A2RU67; -.
DR PaxDb; A2RU67; -.
DR PeptideAtlas; A2RU67; -.
DR PRIDE; A2RU67; -.
DR ProteomicsDB; 502; -.
DR Antibodypedia; 2254; 49 antibodies from 11 providers.
DR DNASU; 57613; -.
DR Ensembl; ENST00000197268.13; ENSP00000197268.8; ENSG00000084444.14.
DR Ensembl; ENST00000416494.6; ENSP00000394063.2; ENSG00000084444.14.
DR GeneID; 57613; -.
DR KEGG; hsa:57613; -.
DR MANE-Select; ENST00000197268.13; ENSP00000197268.8; NM_020853.2; NP_065904.1.
DR UCSC; uc001rbi.4; human.
DR CTD; 57613; -.
DR DisGeNET; 57613; -.
DR GeneCards; FAM234B; -.
DR HGNC; HGNC:29288; FAM234B.
DR HPA; ENSG00000084444; Tissue enhanced (brain).
DR MIM; 617837; gene.
DR neXtProt; NX_A2RU67; -.
DR OpenTargets; ENSG00000084444; -.
DR PharmGKB; PA128395790; -.
DR VEuPathDB; HostDB:ENSG00000084444; -.
DR eggNOG; ENOG502QVNA; Eukaryota.
DR GeneTree; ENSGT00530000063694; -.
DR HOGENOM; CLU_029706_0_0_1; -.
DR InParanoid; A2RU67; -.
DR OMA; FFQHSAN; -.
DR OrthoDB; 294858at2759; -.
DR PhylomeDB; A2RU67; -.
DR TreeFam; TF327203; -.
DR PathwayCommons; A2RU67; -.
DR SignaLink; A2RU67; -.
DR BioGRID-ORCS; 57613; 10 hits in 1067 CRISPR screens.
DR ChiTaRS; FAM234B; human.
DR GenomeRNAi; 57613; -.
DR Pharos; A2RU67; Tdark.
DR PRO; PR:A2RU67; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; A2RU67; protein.
DR Bgee; ENSG00000084444; Expressed in lateral nuclear group of thalamus and 192 other tissues.
DR ExpressionAtlas; A2RU67; baseline and differential.
DR Genevisible; A2RU67; HS.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR045232; FAM234.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR PANTHER; PTHR21419; PTHR21419; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Golgi apparatus; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..622
FT /note="Protein FAM234B"
FT /id="PRO_0000288913"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332"
FT MOD_RES 26
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 33
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332"
FT MOD_RES 62
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT CONFLICT 59
FT /note="E -> K (in Ref. 1; BAC86111)"
FT /evidence="ECO:0000305"
FT CONFLICT 91
FT /note="E -> K (in Ref. 3; AAH39267)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="L -> P (in Ref. 1; BAC86111)"
FT /evidence="ECO:0000305"
FT CONFLICT 450
FT /note="D -> N (in Ref. 2; CAI56785)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 622 AA; 67039 MW; 2C03F481C2FA7DC0 CRC64;
MATVLSRALK LPGKKSPDLG EYDPLTQADS DESEDDLVLN LQKNGGVKNG KSPLGEAPEP
DSDAEVAEAA KPHLSEVTTE GYPSEPLGGL EQKAASSLVS YVRTSVFLLT LGISMILVLL
CAFLIPCPPR DLHSTWSRHL GSQGGGDLSP LELADVNGDG LRDVLLSFVM SRNGSAVGVS
RPAANLVCLS GMNGSTLWSS LLPEEARDIT CLELMPGSLA ETICLVTGTH KMLSAFNATS
GKAIWTLNPN YLSNGTLAAP VVVLPDLDED GVRDLVVLAI GELQPDLCFL LVSGRTGNPV
GRPVKYNIVG VGNLIGPQVY ITTNGAVYIL FGFGNIQAVA LRDIFVQAQN RDSSPPSLQI
EEPEWEKRRS INLSELIDVY SDGVELLQMV KAPDSNCSNL LITTRQSLVL LRGQNLTPYW
ALRLQGLRSQ PTPGYFTDDQ TLDFLLQIQD GVGMKKMMVV DGDSGSIVWS YRAPCHMKET
PATSAVTSDQ KSVFLFWAEG LSAASPNSDI ILGTEPPSLH HLYLLHPAFP SILLDLANTT
GTVTASEVGI NDLWKDAFYV TRTTGPSSEG HPAALVVSKL SLRWALMEGQ MAQLQESTPK
IGRGELRRFL SRIKFVEAPY EI
